Molecular Therapy – Oncolytics: The miR-195 Axis Regulates Chemoresistance through TUBB and Lung Cancer Progression through BIRC5

September 27, 2019

Author links open overlay panelXiaojie Yu126, Yiqiang Zhang1, Binggen Wu13, Jonathan M.Kurie4, Alexander Pertsemlidis125 Chemoresistance and metastasis are the major reasons for non-small cell lung cancer (NSCLC) treatment failure and patient deaths. We and others have shown that miR-195 regulates the sensitivity of NSCLC to microtubule-targeting agents (MTAs) in vitro and in vivo and that miR-195 represses the migration and invasion […]

BioSpace: Hyundai Hope On Wheels Presents UT Health San Antonio With Hyundai Young Investigator And Scholar Hope Grant Totaling A Combined $500,000 To Support Pediatric Cancer Research (Aune & Ignatius Labs)

September 23, 2019

Hyundai Hope On Wheels® (HHOW), a 501(c)(3) non-profit organization supported by Hyundai and its U.S. dealers, announces $500,000 Hyundai Young Investigator and Scholar Hope Grant to UT Health San Antonio to continue its long-standing fight against pediatric cancer. HHOW has committed $13.2 million to support 52 new doctor-researchers in their research for better treatment options and to improve care for children diagnosed […]

Developmental Cell: CENP-A Ubiquitylation Is Indispensable to Cell Viability

September 23, 2019

Summary CENP-A is a centromere-specific histone H3 variant that epigenetically determines centromere identity, but how CENP-A is deposited at the centromere remains obscure. We previously reported that CENP-A K124 ubiquitylation, mediated by the CUL4A-RBX1-COPS8 complex, is essential for CENP-A deposition at the centromere. However, a recent report stated that CENP-A K124R mutants show no defects […]

September is Women in Medicine Month

September 19, 2019

  As part of the American Medical Association (AMA) “Women in Medicine Month”, we at the Greehey Children’s Cancer Research Institute – UT Health San Antonio would like to take a moment and celebrate the female faculty who have dedicated their careers to childhood cancer.     Christine Aguilar, MD, MPH, Faculty Associate, Greehey Children’s […]

KENS5: UT Health gets a $306,000 grant to study Ewing sarcoma

September 16, 2019

SAN ANTONIO — September is Childhood Cancer Awareness Month. One of those cancers, Ewing sarcoma, is the second most common type of bone cancer in children with only 200 diagnosed each year in the U.S. Thanks to a $306,000 grant from The St. Baldrick’s Foundation, UT Health San Antonio is working to find a cure […]

PLOS Biology: Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption

September 12, 2019

Jun Liu , Ming Gao , Michael Nipper, Janice Deng, Francis E. Sharkey, Randy L. Johnson, Howard C. Crawford, Yidong Chen, Pei Wang  Abstract Damaged acinar cells play a passive role in activating pancreatic stellate cells (PSCs) via the recruitment of immune cells that subsequently activate PSCs. However, whether acinar cells directly contribute to PSC activation is […]

KSAT12: Tiny fish in San Antonio lab may hold cure for rare cancer (video)

September 11, 2019

Tiny, see-through fish might be the key to treating children with the rare muscle cancer, rhabdomyosarcoma. Local 13-year-old Kennedie Bailey, who just beat that cancer, saw the little zebrafish that may lead to a new treatment for other kids and prevent tumors from returning.