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SCIENCE DAILY: Finding hints at novel target for Ewing sarcoma therapy
July 17, 2020
Originally Published by: Science Daily New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily […]
UT Health SA Newsroom: Finding published in Nature hints at novel therapeutic target for Ewing sarcoma
July 16, 2020
New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the prestigious journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily affects children and adolescents. The […]
Nature: Nucleolar RNA polymerase II drives ribosome biogenesis
July 15, 2020
Karan J. Abraham, Negin Khosraviani, Janet N. Y. Chan, Aparna Gorthi, Anas Samman, Dorothy Y. Zhao, Miling Wang, Michael Bokros, Elva Vidya, Lauren A. Ostrowski, Roxanne Oshidari, Violena Pietrobon, Parasvi S. Patel, Arash Algouneh, Rajat Singhania, Yupeng Liu, V. Talya Yerlici, Daniel D. De Carvalho, Michael Ohh, Brendan C. Dickson, Razq Hakem, Jack F. Greenblatt, […]
Oncotarget: Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway
July 7, 2020
Ashley VanCleave 1, Mykayla Palmer 1 2, Fang Fang 1, Haydee Torres 1 3, Tania Rodezno 1, Qilin Li 4, Kirby Fuglsby 1 5, Claire Evans 1, Yohannes Afeworki 6, Alan Ross 7, Pulivarthi Rao 8, Patricia Leiferman 9 10, Siyuan Zheng 4, Peter Houghton 4, Jianning Tao 1 3 5 10 Abstract Outcomes have not improved for metastatic osteosarcoma for several decades. In part, this failure to develop better therapies stems from a lack of understanding of osteosarcoma biology, given the rarity of the disease and the high genetic heterogeneity […]
Graduate Student Awarded CPRIT 2020 Predoctoral Training Fellowship (Bishop Lab)
June 22, 2020
Congratulations to Pramiti Mukhopadhyay, Graduate Research Assistant in Alexander J. R. Bishop DPhil lab, on recently being awarded a CPRIT 2020 Predoctoral Training Fellowship. This valuable funding will help Ms. Mukhopadhyay continue her Ewing sarcoma research under the supervision of Dr. Bishop. Pramiti’s accepted proposal for CPRIT 2020 Predoctoral Training Fellowship will focus on the […]
Frontiers in Physics: Predicting Sites of Epitranscriptome Modifications Using Unsupervised Representation Learning Based on Generative Adversarial Networks
June 19, 2020
Sirajul Salekin1, Milad Mostavi1, Yu-Chiao Chiu2, Yidong Chen2,3, Jianqiu Zhang1* and Yufei Huang1,3* Abstract Epitranscriptome is an exciting area that studies different types of modifications in transcripts, and the prediction of such modification sites from the transcript sequence is of significant interest. However, the scarcity of positive sites for most modifications imposes critical challenges for […]
BMC: Age-associated genes in human mammary gland drive human breast cancer progression
June 15, 2020
Xiang Gu, Bingzhi Wang, Haiyan Zhu, You Zhou, Aaron M. Horning, Tim H-M Huang, Yidong Chen, Peter Houghton, Zhao Lai, Joel E. Michalek & Lu-Zhe Sun Abstract Background Aging is a comorbidity of breast cancer suggesting that aging-associated transcriptome changes may promote breast cancer progression. However, the mechanism underlying the age effect on breast cancer remains poorly understood. Method We analyzed transcriptomics of the matched normal […]
Oncogene: Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice (Chen Lab)
June 12, 2020
Chien-Chin Lin, Chi-Yuan Yao, Yueh-Chwen Hsu, Hsin-An Hou, Chang-Tsu Yuan, Yi-Hung Li, Chein-Jun Kao, Po-Han Chuang, Yu-Chiao Chiu, Yidong Chen, Wen-Chien Chou & Hwei-Fang Tien Abstract HOPX is a stem cell marker in hair follicles and intestines. It was shown critical for primitive hematopoiesis. We previously showed an association between higher HOPX expression and clinical characteristics related to stemness and quiescence of leukemic cells in acute myeloid […]
Jove: Mass Spectrometry Analysis to Identify Ubiquitylation of EYFP-tagged CENP-A (EYFP-CENP-A)
June 10, 2020
Yohei Niikura*1, Lei Fang*2, Risa Kitagawa*3, Peizhao Li1, Yao Xi1, Ju You1, Yan Guo2, Katsumi Kitagawa3 Summary CENP-A ubiquitylation is an important requirement for CENP-A deposition at the centromere, inherited through dimerization between cell division, and indispensable to cell viability. Here we describe mass spectrometry analysis to identify ubiquitylation of EYFP-tagged CENP-A (EYFP-CENP-A) protein. Abstract Studying the structure and the dynamics of […]