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February 9, 2009
About 100 scientists from noted cancer centers will gather in downtown San Antonio Feb. 26-27 to share findings and exchange ideas at the Genetics and Biology of Childhood Cancer 2009 symposium. It is the first scientific meeting sponsored by The Greehey Children’s Cancer Research Institute at The University of Texas Health Science Center at San […]
February 1, 2009
J. Keith Killian, Sven Bilke, Sean Davis, Robert L. Walker, M. Scott Killian, Erich B. Jaeger, Yidong Chen, Jason Hipp, Stefania Pittaluga, Mark Raffeld, Robert Cornelison, William I. Smith, Jr., Marina Bibikova, Jian-Bing Fan, Michael R. Emmert-Buck, Elaine S. Jaffe and Paul S. Meltzer Abstract Emerging technologies allow broad profiling of the cancer genome for differential DNA methylation relative to benign cells. Herein, bisulfite-modified DNA from lymph nodes with either reactive hyperplasia or follicular lymphoma (FL) were analyzed using a commercial C/UpG genotyping assay. Two hundred fifty-nine differentially methylated targets […]
December 1, 2008
Yuelin Zhu, Sean Davis, Robert Stephens, Paul S. Meltzer, Yidong Chen Abstract The NCBI Gene Expression Omnibus (GEO) represents the largest public repository of microarray data. However, finding data in GEO can be challenging. We have developed GEOmetadb in an attempt to make querying the GEO metadata both easier and more powerful. All GEO metadata records as well as […]
November 1, 2008
Deborah W Neklason 1, Richard A Kerber, David B Nilson, Hoda Anton-Culver, Ann G Schwartz, Constance A Griffin, Jan T Lowery, Joellen M Schildkraut, James P Evans, Gail E Tomlinson, Louise C Strong, Alexander R Miller, Jill E Stopfer, Dianne M Finkelstein, Prakash M Nadkarni, Carol H Kasten, Geraldine P Mineau, Randall W Burt Abstract Present investigations suggest that approximately 30% of colorectal cancer cases arise on the basis of inherited factors. We […]
October 1, 2008
Hung-I Harry Chen, Fang-Han Hsu, Yuan Jiang, Mong-Hsun Tsai, Pan-Chyr Yang, Paul S. Meltzer, Eric Y. Chuang, Yidong Chen Abstract Motivation: Genomic instability is one of the fundamental factors in tumorigenesis and tumor progression. Many studies have shown that copy-number abnormalities at the DNA level are important in the pathogenesis of cancer. Array comparative genomic hybridization (aCGH), developed based on expression microarray technology, […]
September 13, 2008
Amy M Wiles 1, Dashnamoorthy Ravi, Selvaraj Bhavani, Alexander J R Bishop Abstract Genome-wide RNA interference (RNAi) screening allows investigation of the role of individual genes in a process of choice. Most RNAi screens identify a large number of genes with a continuous gradient in the assessed phenotype. Screeners must decide whether to examine genes with the most robust […]
September 1, 2008
AMY M. WILES,* DASHNAMOORTHY RAVI,* SELVARAJ BHAVANI, and ALEXANDER J. R. BISHOP Genome-wide RNA interference (RNAi) screening allows investigation of the role of individual genes in a process of choice. Most RNAi screens identify a large number of genes with a continuous gradient in the assessed phenotype. Screeners must decide whether to examine genes with […]
July 21, 2008
Jason B Litten 1, Gail E Tomlinson Abstract Malignant liver tumors account for slightly >1% of all pediatric malignancies, with roughly 150 new cases of liver tumors diagnosed in the U.S. annually. The embryonal tumor, hepatoblastoma, accounts for two-thirds of malignant liver tumors in children. Other liver malignancies in children include hepatocellular carcinoma, sarcomas, germ cell tumors, […]
June 27, 2008
Dinesh Rakheja 1, Jacqulin C Cunningham, Midori Mitui, Ashish S Patel, Gail E Tomlinson, Arthur G Weinberg Abstract Cranial fasciitis, an unusual fibroproliferative lesion that occurs in the scalp of infants, is considered a posttraumatic reactive process similar to nodular fasciitis. Its pathobiology has not been investigated. Over the last 15 years, we diagnosed cranial fasciitis in six children; in one […]
April 28, 2008
Anjana Bhardwaj 1, Manjeet K Rao, Ramneet Kaur, Miriam R Buttigieg, Miles F Wilkinson Abstract How Sertoli-specific expression is initiated is poorly understood. Here, we address this issue using the proximal promoter (Pp) from the Rhox5 homeobox gene. Its Sertoli cell-specific expression is achieved, in part, through a negative regulatory element that inhibits Pp transcription in non-Sertoli cell lines. Complementing […]