Category
August 2, 2018
SAN ANTONIO (Aug. 2, 2017) ―Approximately 10 percent of childhood cancer can be attributed to genetics. While genomic analysis has been used for some time to identify the risk of inherited cancer in adults, scientists are now using genomic analysis to identify genetic risk factors and to diagnose cancer at an early age in children. […]
August 1, 2018
Yi Li, Chance M. Nowak, Daniel Withers, Alexander Pertsemlidis, Leonidas Bleris Abstract Unraveling the properties of biological networks is central to understanding both normal and disease cellular phenotypes. Networks consist of functional elements (nodes) that form a variety of diverse connections (edges), with each node being a hub for multiple edges. Herein, in contrast to node-centric network perturbation [...]July 28, 2018
Xiaojie Yuab, Yiqiang Zhanga, Xiuye Maa, Alexander Pertsemlidisabc Abstract Microtubule-targeting agents (MTAs) are widely used for the treatment of non-small cell lung cancer (NSCLC). The response rate is only ∼25%, mainly attributable to drug resistance. To identify the determinants of resistance in NSCLC, we performed a high-throughput screen using a library of miRNA mimics. Here we report that […]
July 1, 2018
AlfeuZanotto-Filhoac SubapriyaRajamanickama EvaLoranca V. Pragathi Masamsettia AparnaGorthiab July CarolinaRomeroab SonalTonapiab Rosangela Mayer Gonçalvesc Robert L.Reddickd RaymondBenavidese JohnKuhnde YidongChenf Alexander J.R.Bishopab Abstract Molecularly targeted compounds are emerging as a strategy to improve classical chemotherapy. Herein, we describe that using a low dose of the multikinase inhibitor sorafenib improves cyclophosphamide antitumor activity by inhibiting angiogenesis, metastasis, and promoting tumor healing in MDA-MB231 xenografts and the 4T1-12B syngeneic breast […]
June 13, 2018
Express-News: STAR Act is a victory for children with cancer Published On: June 13, 2018 Shared by contributor By Gregory J. Aune, MD, PhD For the Express-News President Donald Trump’s signing of the Childhood Cancer Survivorship, Treatment, Access, and Research, or STAR, Act on Tuesday represents a significant legislative achievement in the ongoing battle to improve outcomes […]
May 18, 2018
2016-17 Texas State Presidents Ron Poling and Rachel Graham were proud to present a check for $50,000 to Dr. Houghton, Director of the Greehey Children’s Cancer Research Institute at the University of Texas Health Science Center in San Antonio. Ron and Rachel would like to thank all the Texas State Aerie and Auxiliary members for […]
April 17, 2018
AMID RESEARCH SYMPOSIA dedicated to precise and exacting approaches to cancer—such as targeted therapies, checkpoint inhibitors, and genomic testing—the American Association for Cancer Research brought together seven experts to characterize a complex topic in its own right: cancer survivorship.
April 6, 2018
“Greehey Children’s Cancer Research Institute gets $10.9 million grant” Aune Lab Houghton Lab
April 5, 2018
“Zebrafish are rapidly becoming the ‘go-to’ animals in cancer research” Ignatius Lab
March 8, 2018
Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]