Pigment Cell & Melanoma: Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation (Lai Lab)

September 25, 2024

Erika Soria, Qiusheng Lu, Will Boswell, Kang Du, Yanting Xing, Mikki Boswell, Korri S. Weldon, Zhao Lai, Markita Savage, Manfred Schartl, Yuan Lu ABSTRACT Genetic interactions are adaptive within a species. Hybridization can disrupt such species-specific genetic interactions and creates novel interactions that alter the hybrid progeny overall fitness. Hybrid incompatibility, which refers to degenerative genetic interactions that decrease the overall hybrid survival and sterility, is [...]

Nature: Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination (Sung, Libich)

September 12, 2024

Sameer Salunkhe, James M. Daley, Hardeep Kaur, Nozomi Tomimatsu, Chaoyou Xue, Vivek B. Raina, Angela M. Jasper, Cody M. Rogers, Wenjing Li, Shuo Zhou, Rahul Mojidra, Youngho Kwon, Qingming Fang, Jae-Hoon Ji, Aida Badamchi Shabestari, O’Taveon Fitzgerald, Hoang Dinh, Bipasha Mukherjee, Amyn A. Habib, Robert Hromas, Alexander V. Mazin, Elizabeth V. Wasmuth, Shaun K. Olsen, [...]

Journal of the National Cancer Institute: Integrative multi-omics characterization of hepatocellular carcinoma in Hispanic patients (Zheng, Chen & Lai Labs)

September 4, 2024

Debodipta Das, PhD, Xiaojing Wang, PhD, Yu-Chiao Chiu, PhD, Hakim Bouamar, PhD, Francis E Sharkey, MD, Jorge E Lopera, MD, Zhao Lai, PhD, Susan T Weintraub, PhD, Xianlin Han, PhD, Yi Zou, MS, Hung-I H Chen, PhD, Carla R Zeballos Torrez, MD, PhD, Xiang Gu, PhD, Matyas Cserhati, PhD, Joel E Michalek, PhD, Glenn A Halff, MD, Yidong Chen, PhD, Siyuan Zheng, PhD, Francisco G Cigarroa, MD, Lu-Zhe Sun, Ph Abstract Background The [...]

JNCI Cancer Spectrum: Neighborhood-level social determinants of health burden among adolescent and young adult cancer patients and impact on overall survival (Aune)

September 3, 2024

Elizabeth R Rodriguez, BS, Tori Tonn, BS, Midhat Jafry, BS, Sairah Ahmed, MD, Branko Cuglievan, MD, J Andrew Livingston, MD, Christopher R Flowers, MD, Gregory J Aune, MD, PhD, Karen H Albritton, MD, Michael E Roth, MD, Qian Xiao, PhD, Michelle A T Hildebrandt, PhD Abstract Background Neighborhood socioeconomic deprivation has been linked to adverse health outcomes, yet it is unclear whether neighborhood-level social determinants of [...]

Nature Communications: DSS1 restrains BRCA2’s engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis (Zhao)

August 20, 2024

Yuxin Huang, Wenjing Li, Tzeh Foo, Jae-Hoon Ji, Bo Wu, Nozomi Tomimatsu, Qingming Fang, Boya Gao, Melissa Long, Jingfei Xu, Rouf Maqbool, Bipasha Mukherjee, Tengyang Ni, Salvador Alejo, Yuan He, Sandeep Burma, Li Lan, Bing Xia & Weixing Zhao Abstract DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR), associates with the helical domain (HD) and OB-fold [...]

JNCI Cancer Spectrum: Neighborhood-level Social Determinants of Health Burden among AYA Cancer Patients and Impact on Overall Survival (Aune)

July 29, 2024

Elizabeth R Rodriguez, B.S, Tori Tonn, B.S, Midhat Jafry, B.S, Sairah Ahmed, M.D, Branko Cuglievan, M.D, J Andrew Livingston, M.D, Christopher R Flowers, M.D, Gregory J Aune, M.D., Ph.D, Karen H Albritton, M.D, Michael E Roth, M.D, Qian Xiao, Ph.D, Michelle A T Hildebrandt, Ph.D Abstract Purpose Neighborhood socioeconomic deprivation has been linked to adverse health outcomes. Yet, it is unclear if neighborhood-level social determinants [...]

Science Advances: IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHCII complexes (Gupta Lab)

July 17, 2024

                  ZHIJUN QIU JIHANE KHALIFE,  PURUSHOTH ETHIRAJ CARINE JAAFAR,  AN-PING LIN,  KENNETH N. HOLDER,  JACOB P. RITTER,  LILLY CHIOU GABRIELA HUELGAS-MORALES SADIA ASLAM, ZHAO ZHANG ZHIJIE LIU SHAILEE ARYA,  YOGESH K. GUPTA PATRICIA L. M. DAHIA RICARDO C.T. AGUIAR Abstract The mechanism by which interferon regulatory factor 8 (IRF8) mutation contributes to [...]

MDPI Cells: Comprehensive Review of Uterine Leiomyosarcoma: Pathogenesis, Diagnosis, Prognosis, and Targeted Therapy (Bishop Lab)

July 15, 2024

Qiwei Yang Obianuju Sandra Madueke-Laveaux Han Cun Marta Wlodarczyk Natalia Garcia Katia Candido Carvalho Ayman Al-Hendy Abstract Uterine leiomyosarcoma (uLMS) is the most common subtype of uterine sarcomas. They have a poor prognosis with high rates of recurrence and metastasis. The five-year survival for uLMS patients is between 25 and 76%, with survival rates approaching [...]

JCO Precision Oncology: Disparate Rates of Germline Variants in Cancer Predisposition Genes in African American/Black Compared With Non-Hispanic White Individuals Between 2015 and 2022 (Tomlinson)

July 12, 2024

Rachel B. Wyatt Castillo, MS, CGC, Sarah M. Nielsen, MS, CGC, Elaine Chen, PhD, Brandie Heald, MS, CGC,, Rachel E. Ellsworth, PhD  Edward D. Esplin, MD, PhD, FACMG, and Gail E. Tomlinson, MD, PhD  Abstract Purpose African American/Black (AA/B) individuals are under-represented in genomic databases and thus less likely to receive definitive information from germline genetic testing (GGT) than non-Hispanic White (NHW) individuals. With nearly 500,000 AA/B and [...]

eLife: SERBP1 interacts with PARP1 and is Present in PARylation-Dependent Protein Complexes Regulating Splicing, Cell Division, and Ribosome Biogenesis (Penalva, Libich, et al)

July 3, 2024

Kira Breunig Xiufen Lei Mauro Montalbano Gabriela D. A. Guardia Shiva Ostadrahimi Victoria Alers Adam Kosti Jennifer Chiou Nicole Klein Corina Vinarov Lily Wang Mujia Li Weidan Song W. Lee Kraus David S. Libich Stefano Tiziani Susan T. Weintraub Pedro A. F. Galante Luiz O. F. Penalva Abstract RNA binding proteins (RBPs) containing intrinsically disordered [...]