December 25, 2021
by Mirella Baroni 1 , Gabriela D. A. Guardia 2 , Xiufen Lei 1, Adam Kosti 1,3, Mei Qiao 1, Tesha Landry 1, Karl Mau 1, Pedro A. F. Galante 2 and Luiz O. F. Penalva Abstract Medulloblastoma is the most common malignant brain tumor in children. Treatment with surgery, irradiation, and chemotherapy has improved [...]October 13, 2021
Antoine Baudin, 1 , 2 , † Alma K. Moreno-Romero, 1 , 2 Xiaoping Xu, 1 , 2 Emily E. Selig, 1 , 2 , † Luiz O. F. Penalva, 1 , 3 and David S. Libich 1 , 2 ,* † Abstract RNA binding proteins (RBPs) are essential for critical biological processes such as translation regulation and mRNA processing, and misfunctions of these proteins are associated with diseases such as cancer and neurodegeneration. SERBP1 (SERPINE1 [...]June 21, 2021
Join us in congratulating Adam Kosti of the Penalva Lab for successfully defending his dissertation, “microRNA-Transcription Factor Networks in Gliomagenesis” last week. Mentor: Dr. Luiz Penalva Program: PhD in Integrated Biomedical Sciences Discipline: Cancer Biology Way to go Adam! __________________________________________________________ Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey […]
June 7, 2021
Greehey CCRI would like to welcome the 2021 Donald G McEwen, Memorial Summer Undergraduate Research Program students. Gaby Ruban – Dr. Chen Misa Ito – Dr. Ignatius Jingsi Zhou – Dr. Kitagawa Hoang Dinh – Dr. Libich Gabriella Quintanilla – Dr. Penalva Shresth Arya – […]
May 25, 2021
Congratulations to Adam Kosti from the Luiz O.F. Penalva, PhD Lab on being awarded the Barbara Bowman Endowment In Cellular & Structural Biology Award for the second year in a row. Learn more about Adam’s related papers: Molecular Cancer Research: ELF4 Is a Target of […]
March 30, 2021
Carla Frau, Catherine Jamard, Gaspard Delpouve, Gabriela D. A. Guardia, Christelle Machon, Camilla Pilati, Clementine Le Neve, Pierre Laurent-Puig, Jérôme Guitton, Pedro A. F. Galante, Luiz O. Penalva, Jean-Noel Freund, Christelle de la Fouchardière and Michelina Plateroti Abstract Intestinal crypts are composed of heterogeneous and highly plastic cell populations. Lgr5high-stem cells (SC) are responsible for homeostatic renewal, but other cells can revert to an SC-like phenotype to maintain epithelial integrity. Despite their distinct roles in orchestrating homeostasis, both populations have been designated as […]
March 30, 2021
Matthias Godart, Carla Frau, Diana Farhat, Maria Virginia Giolito, Catherine Jamard, Clementine Le Nevé, Jean-Noel Freund, Luiz O. Penalva, Maria Sirakov, Michelina Plateroti Abstract The thyroid hormone T3 and its nuclear receptor TRα1 control gut development and homeostasis through the modulation of intestinal crypt cell proliferation. Despite increasing data, in-depth analysis on their specific action on intestinal stem cells is lacking. By using ex vivo 3D […]
March 30, 2021
Mirella Baroni 1,†, OrcID,Caihong Yi 1,2,†, Saket Choudhary 3,†, Xiufen Lei 1, Adam Kosti 1,4, Denise Grieshober 1, Mitzli Velasco 1, Mei Qiao 1, Suzanne S. Burns 1,‡, Patricia R. Araujo 1, Talia DeLambre 1, Mi Young Son 5, Michelina Plateroti 6, Marco A. R. Ferreira 7, Paul Hasty 5, and. Luiz O. F. Penalva […]
January 14, 2021
Adam Kosti, Rodrigo Barreiro, Gabriela D. A. Guardia, Shiva Ostadrahimi, Erzsebet Kokovay, Alexander Pertsemlidis, Pedro A. F. Galante, Luiz O. F. Penalva Simple Summary miRNAs function as critical regulators of gene expression and have been defined as contributors to cancer phenotypes by acting as oncogenes or tumor suppressors. Based on these findings, miRNA-based therapies have been explored in the treatment of many […]
December 5, 2020
Rebecca Pötschke 1,2,† Jacob Haase 1,†, Markus Glaß 1 Sebastian Simmermacher 3,Claudia Misiak 1,Luiz O. F. Penalva 4,5 Caspar D. Kühnöl, 2 and Stefan Hüttelmaier 1, Simple Summary Glioblastoma (GBM) is the most lethal brain tumor with a median survival rate of approximately 14 months. GBM patients commonly suffer from tumor recurrence, indicating that populations of chemo/radio-resistant stem cell-like tumor cells […]