August 20, 2020
PROJECT SUMMARY Glioblastoma (GBM) is the most common and most aggressive brain tumor type among adults with a 14 months average patient survival. Despite all genomic efforts in recent years, novel therapies based on GBM common mutations and alterations have been disappointing. To build an alternative route, we have been focusing on oncogenic RNA binding […]
August 20, 2020
Background RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification and characterization of oncogenic RBPs and their regulatory networks provide new opportunities for targeted therapy. Results We identify the RNA-binding protein SERBP1 […]
August 20, 2020
PROJECT SUMMARY Glioblastoma (GBM) is the most common and most aggressive brain tumor type among adults with a 14 months average patient survival. Despite all genomic efforts in recent years, novel therapies based on GBM common mutations and alterations have been disappointing. To build an alternative route, we have been focusing on oncogenic RNA binding [...]August 6, 2020
Adam Kosti 1 2, Patricia Rosa de Araujo 1 2, Wei-Qing Li 1 3, Gabriela D A Guardia 4, Jennifer Chiou 5, Caihong Yi 1, Debashish Ray 6, Fabiana Meliso 4, Yi-Ming Li 3, Talia Delambre 1, Mei Qiao 1, Suzanne S Burns 1, Franziska K Lorbeer 1, Fanny Georgi 1, Markus Flosbach 1, Sarah Klinnert 1, Anne Jenseit 1, Xiufen Lei 1, Carolina Romero Sandoval 1, Kevin Ha 6, Hong Zheng 6, Renu Pandey 1, Aleksandra Gruslova 7, Yogesh K Gupta 1, Andrew Brenner 8, Erzsebet Kokovay 2, Timothy R Hughes 6 9 10, Quaid D Morris 6 9 11, Pedro A F Galante 12, Stefano Tiziani 13, Luiz O F Penalva 14 15 Abstract Background: RNA-binding proteins (RBPs) function as master regulators […]
February 22, 2020
“Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles” Abstract Therapy resistance and recurrence in high-grade gliomas are driven by their populations of glioma stem cells (GSCs). Thus, detailed molecular characterization of GSCs is needed to develop more effective therapies. We conducted a study to identify differences in the splicing […]
February 6, 2020
Zhe Zhu, Pinar Mesci, Jean A Bernatchez, Ryan C Gimple, Xiuxing Wang, Simon T Schafer, Hiromi I Wettersten, Sungjun Beck, Alex E Clark, Qiulian Wu, Briana C Prager, Leo JY Kim, Rekha Dhanwani, Sonia Sharma, Alexandra Garancher, Sara M Weis, Stephen C Mack, Priscilla D Negraes, Cleber A Trujillo, Luiz O Penalva, Jing Feng, Zhou […]
January 10, 2020
ELF4 is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated State Abstract 13-Cis-retinoic acid (RA) is typically used in postremission maintenance therapy in patients with neuroblastoma. However, side effects and recurrence are often observed. We investigated the use of miRNAs as a strategy to replace RA as promoters of differentiation. miR-124 was identified […]
January 1, 2020
Adam Kosti, Liqin Du, Haridha Shivram, Mei Qiao, Suzanne Burns, Juan Gabriel Garcia, Alexander Pertsemlidis, Vishwanath R Iyer, Erzsebet Kokovay, Luiz OF Penalva 13-Cis-retinoic acid (RA) is typically used in postremission maintenance therapy in patients with neuroblastoma. However, side effects and recurrence are often observed. We investigated the use of miRNAs as a strategy to […]
January 1, 2020
Choudhary Saket, Suzanne C Burns, Mirsafian Hoda, Wenzheng Li, Dat T Vo, Qiao Mei, Lei Xiufen, Andrew D Smith, Luiz O Penalva High-dose radiation is the main component of glioblastoma therapy. Unfortunately, radio-resistance is a common problem and a major contributor to tumor relapse. Understanding the molecular mechanisms driving response to radiation is critical for […]
January 1, 2020
Sajina Shakya, Anthony D Gromovsky, James S Hale, Arnon M Knudsen, Briana Prager, Lisa C Wallace, Luiz OF Penalva, Pavlina Ivanova, H Alex Brown, Bjarne W Kristensen, Jeremy N Rich, Justin D Lathia, J Mark Brown, Christopher G Hubert Background: Glioblastoma (GBM) is marked by cellular heterogeneity, including metabolic heterogeneity, that varies among cellular microenvironments […]