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Lai Lab

Zhao Lai, PhD

Zhao Lai, PhD

Rank: Associate Professor/Research
Department: Molecular Medicine
Office: 4.100.14
Tel: 210-562-9246
laiz@uthscsa.eduEmail

Dr. Zhao Lai is the Director of the Genome Sequencing Facility (GSF) of Greehey CCRI at the UT Health – San Antonio (UTHSA). The GSF utilizes high throughput sequencing platforms to generate high-quality genomic data and provides support to its analysis for a large number of faculty members at Greehey CCRI, May’s Cancer Center, and UTHSA entire campus. The GSF focuses on the various aspects of functional genomics and applications using next-generation sequencing technology. Especially, the GSF assists the PIs to carry out various aspects of genomic studies such as heterogeneity of cell population, cancer driver/rare mutation characterization, biomarker development, and gene expression regulation and network of pathways, using NGS technology.

Dr. Zhao Lai was trained as a genomics scientist with over 20 years of extensive research experience and has co-authored more than 60 peer-reviewed publications and several book chapters. She has guided the establishment and development of every aspect of the Genome Sequencing Facility, including project budgeting and coordination, equipment acquisition and maintenance, training and supervising staff scientists, establishing all standard operating procedures (SOPs), creating a working pipeline from experimental design through subsequent data interpretation of experiments with investigators, and assessing the current and future NGS needs to satisfy the diverse research portfolio of the UTHSA scientific community. As the Director of GSF, Dr. Lai has continually established and significantly expanded the NGS services to develop a comprehensive portfolio of NGS protocols, secured NIH instrument grant S10 to improve the genomic infrastructure, contributed multiple high throughput sequencing studies, and supported diverse biomedical research applications and numerous NIH funded projects.

UTHSA Faculty Profile: Zhao Lai, PhD

Lab Research

Expertise

Lab Staff

Mandy Hinojosa, BS
Senior Genomics Technologist

Korri Sue Weldon, BS        
Senior Genomics Technologist


Former Lab Members

Dawn Garcia, MS
Technical Director

Featured News

Greehey CCRI’s Genomic Sequencing Facility to Receive $600,000 NIH Grant to upgrade genomic sequencing capabilities (Lai Lab).

Mucosal Immunology: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

Scientific Reports: “Transcriptomic Sex Differences in Sensory Neuronal Populations of Mice”

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

News

Zhao Lai, PhD to Receive $365K NIH Grant to Expand Integrated High-Performance Imaging-Based in-situ Spatial Profiling
July 8, 2025

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

NPJ – Precision Oncology: Benchmarking mouse contamination removing protocols in patient-derived xenografts genomic profiling (Zheng, Wang, Kurmasheva, Houghton, Lai, & Chen Labs)
April 17, 2025

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

Pigment Cell & Melanoma: Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation (Lai Lab)
September 25, 2024

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

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