MDPI: Design and Characterization of a Cell-Penetrating Peptide Derived from the SOX2 Transcription Factor (Blancafort)
September 10, 2021Neha S. Gandhi Edina Wang Anabel Sorolla Yu Jie Kan Adil Malik Jyotsna Batra Kimberly A. Young Wan Jun Tie Pilar Blancafort Ricardo L. Mancera Abstract SOX2 is an oncogenic transcription factor overexpressed in nearly half of the basal-like triple-nega …
European Journal of Cancer: Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: A systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group (Aune)
September 9, 2021Elvira C.van Dalena Renée L.Muldera EugeneSuhb Matthew J.Ehrhardtc Gregory J.Auned EditBardief Bradley J.Bensong JuttaBergler-Kleinh Ming H.Cheni EvaFreyf UlrikeHennewigj LianeLockwoodk UllaMartinssonl MonicaMuracam Helenavan der Pala ChrisPlummern …
Cancer Research: SNAI2-mediated repression of BIM protects rhabdomyosarcoma from ionizing radiation (Houghton, Ignatius, & Zheng Labs)
August 31, 2021Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. C …
Frontiers in Immunolgy: Manipulating the NKG2D Receptor-Ligand Axis Using CRISPR: Novel Technologies for Improved Host Immunity (Blancafort)
August 30, 2021Eric Alves1,2*,Emily McLeish3,Pilar Blancafort1,2,4,Jerome D. Coudert3,5,6†Silvana Gaudieri1,7,8† Abstract The activating immune receptor natural killer group member D (NKG2D) and its cognate ligands represent a fundamental surveillance system of cellu …
Pediatric Blood & Cancer: In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC) (Kurmasheva, Houghton)
August 30, 2021Raushan T. Kurmasheva, Stephen W. Erickson, Ruolan Han, Beverly A. Teicher, Malcolm A. Smith, Michael Roth, Richard Gorlick, Peter J. Houghton Abstract SP-2577(Seclidemstat), an inhibitor of lysine-specific demthylase KDM1A (LSD1) that is overexpressed …
Biomolecular NMR Assignments: The 1H, 15N and 13C resonance assignments of the C‑terminal domain of Serpine mRNA binding protein 1 (SERBP1), (Libich Lab)
August 30, 2021Antoine Baudin, Xiaoping Xu & David S. Libich Abstract SERBP1 is a multifunctional mRNA-binding protein that has been shown to play a regulatory role in a number of biological processes such as thrombosis, DNA damage repair, and the cellular respon …
Journal of Trauma & Acute Care Surgery: Whole Blood Resuscitation Restores Intestinal Perfusion and Influences Gut Microbiome Diversity (Lai)
August 24, 2021Yracheta, Jaclyn MD1; Muraoka, Wayne PhD2; Wu, Xiaowu MD2; Burmeister, David PhD3; Darlington, Daniel PhD2; Zhao, David MD2; Lai, Zhao PhD4; Scroggins, Shannon MS1; Cap, Andrew P. MD, PhD2; Bynum, James PhD2; Nicholson, Susannah E. MD1,2 Abstract Objec …
Science Advances: Predicting and characterizing a cancer dependency map of tumors with deep learning (Aune, Chen, Rao, Houghton & Zheng Labs)
August 24, 2021Yu-Chiao Chiu1, Siyuan Zheng1,2, Li-Ju Wang1, View ORCID ProfileBrian S. Iskra1, View ORCID ProfileManjeet K. Rao1,3, Peter J. Houghton1,4, View ORCID ProfileYufei Huang5,6,* and View ORCID ProfileYidong Chen1,2,* Abstract Genome-wide loss-of-function …
Drs Houghton and Kurmasheva to Receive 5-year, $2.9M NCI Pediatric In Vivo Testing Program (PIVOT) U01 Grant Renewal
August 10, 2021NCI Pediatric In Vivo Testing Program (U01), renewal for the previous PPTC (Pediatric Preclinical Testing Consortium). Grant period: July 2021-June 2026. Total dollar amount: $2,900,000 over 5 years. Abstract Cancer in children is rare with …
BRCA2 Promotes Spontaneous Homologous Recombination In Vivo (Bishop)
August 9, 2021Adam D. Brown, Scott Greenman, Alison B. Claybon, Alexander J. R. Bishop Simple Summary Inherited mutation of either BRCA1 or BRCA2 is associated with familial breast and ovarian cancer. As a tumor suppressor, BRCA2 functions to maintain genome stabili …