BioMolecular NMR Assignments: The 1H, 15N and 13C backbone resonance assignments of the N-terminal (1-149) domain of Serpine mRNA Binding Protein 1 (SERBP1) (Libich Lab)
May 30, 2025Antoine Baudin, Hoang H. Dinh, Xiaoping Xu & David S. Libich Abstract Serpine mRNA-Binding Protein 1 (SERBP1) is an RNA-binding protein implicated in diverse cellular functions, including translational regulation, tumor progression, and stress resp …
Science: CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade (Sung & Libich Labs)
May 23, 2025Cody M. Rogers, Hardeep Kaur, Michelle L. Swift , Vivek B. Raina , Shuo Zhou , Ajinkya S. Kawale Shahrez Syed , Korilynn G. Kelly , Angela M. Jasper , Sameer Salunkhe, Youngho Kwon , Jeffrey Wang, Aida Badamchi Shabestari, James M. Daley, Adam Sacks , …
PNAS: Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain (Libich & Bishop Labs)
May 16, 2025Emily E. Selig Erich J. Sohn Aiola Stoja, Alma K. Moreno-Romero, Shivani Akula, Xiaoping Xu, Alexander J. R. Bishop, and David S. Libich Significance The oncogenic fusion protein, EWS::FLI1, responsible for more than 85% of Ewing sarcoma tumors, comb …
Cell Reports: Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation (Sung, Libich Labs)
May 7, 2025Francisco E. Neal1,2 ∙ Wenjing Li1 ∙ Mollie E. Uhrig3,4 ∙ Jeffrey N. Katz1,2 ∙ Shahrez Syed1,2 ∙ Neelam Sharma3 ∙ Arijit Dutta1,2,8 ∙ Sandeep Burma1,5 ∙ Robert Hromas6 ∙ Alexander V. Mazin1 ∙ Eloise Dray1 ∙ David S. Libich1,2 ∙ Shaun K. Olsen1,2 ∙ Eliz …
Biomolecular NMR Assignments: The 1H, 15N and 13C backbone resonance assignments of the N-terminal (1-149) domain of Serpine mRNA Binding Protein 1 (SERBP1) (Libich Lab)
March 31, 2025Antoine Baudin1, Hoang H Dinh1, Xiaoping Xu1, David S Libich2 Abstract Serpine mRNA-Binding Protein 1 (SERBP1) is an RNA-binding protein implicated in diverse cellular functions, including translational regulation, tumor progression, and stress respons …
ELife: SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis (Libich, Penalva, et al)
February 13, 2025Kira Breunig#1, Xuifen Lei#1, Mauro Montalbano#23, Gabriela D A Guardia4, Shiva Ostadrahimi15, Victoria Alers156, Adam Kosti15, Jennifer Chiou7, Nicole Klein1, Corina Vinarov1, Lily Wang1, Mujia Li1, Weidan Song8, W Lee Kraus8, David S Libich16, Stefan …
Molecular Oncology: Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma (Libich Lab)
October 3, 2024Erich J. Sohn, David S. Libich Abstract Ewing sarcoma, an aggressive pediatric cancer, is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF chromatin remodeling complex. Central to this mechanism is the formati …
Nature: Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination (Sung, Libich)
September 12, 2024Sameer Salunkhe, James M. Daley, Hardeep Kaur, Nozomi Tomimatsu, Chaoyou Xue, Vivek B. Raina, Angela M. Jasper, Cody M. Rogers, Wenjing Li, Shuo Zhou, Rahul Mojidra, Youngho Kwon, Qingming Fang, Jae-Hoon Ji, Aida Badamchi Shabestari, O’Taveon Fitzgeral …
eLife: SERBP1 interacts with PARP1 and is Present in PARylation-Dependent Protein Complexes Regulating Splicing, Cell Division, and Ribosome Biogenesis (Penalva, Libich, et al)
July 3, 2024Kira Breunig Xiufen Lei Mauro Montalbano Gabriela D. A. Guardia Shiva Ostadrahimi Victoria Alers Adam Kosti Jennifer Chiou Nicole Klein Corina Vinarov Lily Wang Mujia Li Weidan Song W. Lee Kraus David S. Libich Stefano Tiziani Susan T. Weintraub Pedro …
Journal of the American Chemical Society: ights into Molecular Diversity within the FUS/EWS/TAF15 Protein Family: Unraveling Phase Separation of the N-Terminal Low-Complexity Domain from RNA-Binding Protein EWS (Libich Lab)
April 8, 2024Abstract The FET protein family, comprising FUS, EWS, and TAF15, plays crucial roles in mRNA maturation, transcriptional regulation, and DNA damage response. Clinically, they are linked to Ewing family tumors and neurodegenerative diseases such as amyo …
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