Greehey CCRI News & Events Archive

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Genes & Development: Lineage of origin in rhabdomyosarcoma informs pharmacological response

June 3, 2014

Jinu Abraham1, Yaiza Nuñez-Álvarez2, Simone Hettmer3,4, Elvira Carrió2, Hung-I Harry Chen5, Koichi Nishijo5, Elaine T. Huang1, Suresh I. Prajapati5, Robert L. Walker6, Sean Davis6, Jennifer Rebeles5, Hunter Wiebush5, Amanda T. McCleish5, Sheila T. Hamp …


Cell Reports: Negative Elongation Factor Controls Energy Homeostasis in Cardiomyocytes

April 17, 2014

HaihuiPan1 KunhuaQin1 ZhanyongGuo23 YonggangMa4CraigApril7 XiaoliGao5T homas G.Andrews2 AlexBokov3 JianhuaZhang4 YidongChen23 Susan T.Weintraub5 Jian-BingFan7 DegengWang 23YanfenHu1 Gregory J.Aune26 Merry L.Lindsey4 RongLi1 Summary Negative elongation …


Cell Reports: Negative Elongation Factor Controls Energy Homeostasis in Cardiomyocytes

April 10, 2014

HaihuiPan1,KunhuaQin1  ZhanyongGuo23 YonggangMa4  CraigApril7  XiaoliGao5 Thomas G.Andrews2 AlexBokov3 JianhuaZhang4 YidongChen23 Susan T.Weintraub5 Jian-BingFan7 DegengWang23 YanfenHu1 Gregory J.Aune26  Merry L.Lindsey4 RongLi1 Summary Negative elonga …


Cancer Prevention Research: Pubertal Bisphenol A Exposure Alters Murine Mammary Stem Cell Function Leading to Early Neoplasia in Regenerated Glands

April 1, 2014

Danhan Wang, Hui Gao, Abhik Bandyopadhyay, Anqi Wu, I-Tien Yeh, Yidong Chen, Yi Zou, Changjiang Huang, Christi A. Walter, Qiaoxiang Dong, and Lu-Zhe Sun Abstract Perinatal exposure to bisphenol A (BPA) has been shown to cause aberrant mammary gland mor …


PLOS One: ATR Suppresses Endogenous DNA Damage and Allows Completion of Homologous Recombination Repair

March 27, 2014

Adam D. Brown, Brian W. Sager, Aparna Gorthi, Sonal S. Tonapi, Eric J. Brown, Alexander J. R. Bishop  Abstract DNA replication fork stalling or collapse that arises from endogenous damage poses a serious threat to genome stability, but cells invoke an …


Cell Reports: Negative elongation factor controls energy homeostasis in cardiomyocytes.

March 19, 2014

Abstract Pan H1, Qin K1, Guo Z2,Ma Y3,April C4,Gao X5,Andrews TG6,Bokov A7,Zhang J3,Chen Y2,Weintraub ST5,Fan JB4,Wang D2,Hu Y1,Aune GJ8,Lindsey ML3 Li R1 Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase …


Europe PMCP: Negative elongation factor controls energy homeostasis in cardiomyocytes. (Aune & Chen)

March 19, 2014

Abstract Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a pervasive phenomenon observed across multicellular genomes. However, the physiological impact of NELF on tissue homeostasis remain …


Bioinformatics: A novel significance score for gene selection and ranking

March 15, 2014

Yufei Xiao, Tzu-Hung Hsiao, Uthra Suresh, Hung-I Harry Chen, Xiaowu Wu, Steven E. Wolf, Yidong Chen Abstract Motivation: When identifying differentially expressed (DE) genes from high-throughput gene expression measurements, we would like to take both …


Science Daily: Improved screening means new targets for pediatric neuroblastoma therapies

March 2, 2014

Neuroblastoma is one of the most common and lethal types of childhood cancers. In a paper recently published, a researcher unveils an improved screening technique that shows the important role of microRNAs in regulating neuroblastoma development, point …


Oncotarget: A high-content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation

February 28, 2014

Zhenze Zhao1, Xiuye Ma1, Tzu-Hung Hsiao1, Gregory Lin1, Adam Kosti1, Xiaojie Yu2, Uthra Suresh1, Yidong Chen1,3, Gail E. Tomlinson1,4, Alexander Pertsemlidis1,4,5, Liqin Du1,5 ABSTRACT Neuroblastoma, the most common extracranial solid tumor of childhoo …