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Translating Today's Discoveries in Childhood Cancer Research into Tomorrow's Treatments.

The Greehey Children’s Cancer Research Institute is one of only two institutes in the United States exclusively focused on pediatric cancer research. With 19 laboratories, the institute leverages expertise in cancer genomics, DNA repair, RNA biology, and drug development to discover new and less harmful treatments for childhood cancers.

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In The News

Our research expertise spans cancer genomics, DNA damage, RNA biology, and drug development. We are also expanding our focus on drug delivery, particularly through nanotechnology-based methods for delivering small RNA mimics and inhibitors.

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KSAT12: Hyundai Hope On Wheels Provides $500,000 to UT San Antonio Pediatric Cancer Research Group

Science Advances: Evidence of active whole-genome doubling (WGD) subclones in non-WGD tumors (Zheng, Ignatius)

Nature Communications: Saturation mutagenesis enables RAD51D clinical variant interpretation and identifies distinct biochemical functions (Sung/Olsen)

Nature Reviews – Molecular Cell Biology: Mechanisms and Disease Relevance of DNA Break Repair Pathway Choice (Sung Lab)

News

  • Congrats DOCTOR Erich Sohn!!

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Science Advances: Evidence of active whole-genome doubling (WGD) subclones in non-WGD tumors (Zheng, Ignatius)

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Springer Nature: The1H, 15N and13C backbone resonance assignments of an intrinsically disordered region (124–270) of BRCA1 associated RING domain 1 (BARD1) (Sung & Libich Labs)

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Application Window Now Open for the 2027 Greehey CCRI Summer Research Program!

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Nature Reviews – Molecular Cell Biology: Mechanisms and Disease Relevance of DNA Break Repair Pathway Choice (Sung Lab)

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

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Events
Greehey CCRI Seminar Series – Fall ’26: Jeanne Stachowiak, PhD (UT Austin)

Presentation title: Intrinsic Disorder as an Organizing Principle for Cellular Membranes
Greehey CCRI Fall ’26 Seminar Series: Reuben Harris, PhD (UTHSA)

Presentation title: “Progress on the development of novel drugs for viral proteases”
Greehey CCRI Seminar Series – Fall ’26 Elif Sarinay Cenik, PhD (UT Austin)

Presentation title: How Ribosome Nucleolar Defects Create Metabolic and Chromatin Vulnerabilities
Greehey CCRI Seminar Series – Diana Hargreaves, PhD (Salk Institute)

Presentation title: TBD

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