Category
May 1, 2019
Siyuan Zheng, Kristin Alfaro-Munoz, Wei Wei, Xiaojing Wang, Fang Wang, Agda Karina Eterovic, Kenna R Mills Shaw, Funda Meric-Bernstam, Gregory N Fuller, Ken Chen, Roel G Verhaak, Gordon B Mills, WK Alfred Yung, Shiao-Pei Weathers, John F de Groot Malignant gliomas are a group of intracranial cancers associated with disproportionately high mortality and morbidity. Here, […]
May 1, 2019
Siyuan Zheng 1 2 3, Kristin Alfaro-Munoz 4, Wei Wei 5, Xiaojing Wang 3, Fang Wang 6, Agda Karina Eterovic 7, Kenna R Mills Shaw 7, Funda Meric-Bernstam 7, Gregory N Fuller 8, Ken Chen 6, Roel G Verhaak 4 2 6 9, Gordon B Mills 7, W K Alfred Yung 4, Shiao-Pei Weathers 4, John F de Groot 1 Abstract Malignant gliomas are a group of intracranial cancers associated with disproportionately high mortality and morbidity. Here, we report ultradeep targeted sequencing of a prospective cohort of 237 […]
April 25, 2019
Caitlin D Lowery 1, Michele Dowless 1, Matthew Renschler 1, Wayne Blosser 1, Alle B VanWye 1, Jennifer R Stephens 1, Philip W Iversen 1, Aimee Bence Lin 1, Richard P Beckmann 1, Kateryna Krytska 2, Kristina A Cole 2, John M Maris 2, Douglas S Hawkins 3, Brian P Rubin 4, Raushan T Kurmasheva 5, Peter J Houghton 5, Richard Gorlick 6, E Anders Kolb 7, Min H Kang 8, C Patrick Reynolds 8, Stephen W Erickson 9, Beverly A Teicher 10, Malcolm A Smith 10, Louis F Stancato 11 Abstract Purpose: Checkpoint kinase 1 (CHK1) inhibitors potentiate the DNA-damaging effects of […]
April 23, 2019
Luke Jones, Hannah McCalmont, Kathryn Evans, Chelsea Mayoh, Raushan T. Kurmasheva, Catherine A. Billups, Peter J. Houghton, Malcolm A. Smith, Richard B. Lock Abstract Background Denintuzumab mafodotin (SGN‐CD19A) is a CD19‐targeting antibody‐drug conjugate, comprising a monoclonal antibody conjugated to the potent cytotoxin monomethyl auristatin F. Since denintuzumab mafodotin has previously shown activity against B‐cell malignancies in early‐stage clinical trials, it […]
April 19, 2019
When Gregory Aune was 16, he wasn’t particularly concerned about the lasting effects of the drugs and radiation that he was given to treat his lymphoma. “I saw kids around me die, so I felt pretty fortunate,” he says. Nearly 30 years later, Aune has a slightly different perspective. He’s still deeply grateful to have […]
April 19, 2019
Mitzli X Velasco, Adam Kosti, Gabriela DA Guardia, Marcia C Santos, Allison Tegge, Mei Qiao, Bruna RS Correa, Greco Hernández, Erzsebet Kokovay, Pedro AF Galante, Luiz OF Penalva Abstract RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We identified Musashi1 (Msi1) and miR-137 […]
April 17, 2019
Mingkui Zhou, Michael Humbert, Muhammad M. Mukhtar, Hanna B. Scinto, Hemant K. Vyas, Samir K. Lakhashe, Siddappa N. Byrareddy, Gregor Maurer, Swati Thorat, Joshua Owuor, Zhao Lai, Yidong Chen, Anthony Griffiths, Agnès-Laurence Chenine, Sanjeev Gumber, François Villinger, David Montefiori, Ruth M. Ruprecht ABSTRACT Simian-human immunodeficiency virus (SHIV) infection in rhesus macaques (RMs) resembles human immunodeficiency virus type 1 (HIV-1) infection in humans and serves as a tool to evaluate candidate AIDS vaccines. […]
April 11, 2019
Katherine Haines 1, Stephen F Sarabia 2 3, Karla R Alvarez 2 3, Gail Tomlinson 4, Sanjeev A Vasudevan 3 5, Andras A Heczey 3 6, Angshumoy Roy 2 3, Milton J Finegold 2, D Williams Parsons 1 3 6, Sharon E Plon 1 3 6, Dolores López-Terrada 2 3 Abstract Background: Pediatric hepatocellular carcinoma (HCC) is a rare liver tumor in children with a poor prognosis. Comprehensive molecular profiling to understand the underlying genomic drivers of this tumor has not been completed, and it is unclear […]
April 10, 2019
David Libich, PhD, assistant professor of biochemistry and structural biology in the Long School of Medicine and faculty member of UT Health’s Greehey Children’s Cancer Research Institute, has received a Rising STARs Award from the UT System. The award for early-career investigators comes with a $250,000 grant. Dr. Libich, who began work here in 2017, […]
April 9, 2019
More and more people are living for years after treatment. Researchers should look for ways to identify and ease long-term effects. When Gregory Aune was 16, he wasn’t particularly concerned about the lasting effects of the drugs and radiation that he was given to treat his lymphoma. “I saw kids around me die, so I […]