Category
June 18, 2019
William L. Henrich, MD, MACP, president of UT Health San Antonio, announced that the Max and Minnie Tomerlin Voelcker Fund is giving $900,000 to the university to support two research projects and one pilot research project, all conducted by rising young faculty.
June 12, 2019
Trevi R. Mancilla, Brian Iskra, Gregory J. Aune ABSTRACT Doxorubicin‐induced cardiotoxicity in childhood cancer survivors is a growing problem. The population of patients at risk for cardiovascular disease is steadily increasing, as five‐year survival rates for all types of childhood cancers continue to improve. Doxorubicin affects the developing heart differently from the adult heart and in a […]
June 6, 2019
Published On: June 6, 2019 Shared by Joe Feist Pediatric oncologist and researcher Gregory Aune, MD, PhD, tells the story of his favorite patient, a teenage boy some 30 years ago who was diagnosed with Hodgkin’s lymphoma. The patient survived but has experienced many health complications as a direct result of the cancer treatments, including a […]
June 1, 2019
Yael P Mossé 1 2, Elizabeth Fox 3 2, David T Teachey 3 2, Joel M Reid 4, Stephanie L Safgren 4, Hernan Carol 5, Richard B Lock 5, Peter J Houghton 6, Malcolm A Smith 7, David Hall 8, Donald A Barkauskas 8, Mark Krailo 9, Stephan D Voss 10, Stacey L Berg 11, Susan M Blaney 11, Brenda J Weigel 10 Abstract Purpose: Aurora A kinase (AAK) plays an integral role in the mitotic entry, DNA damage checkpoint recovery, and centrosome and spindle maturation. Alisertib (MLN8237) is a […]
June 1, 2019
JorgeDe La Chapaa, Matthew Valdezb, Franscisco RuizIIIb, Keith Gonzalesb, Wes Mitchellb, Stanton F.McHardybc, Matthew Hartbc, Srikanth R.Polusanib, Cara B.Gonzalesac Abstract We previously demonstrated that capsazepine (CPZ), a synthetic transient receptor potential Vanilloid subtype 1 (TRPV1) antagonist, has significant anti-cancer effects in vivo. The purpose of this study was to develop more potent analogs based upon CPZ pharmacophore and structure-activity relationships (SAR) across analogs. We […]
May 29, 2019
“Greg Aune, M.D. addresses attendees of the 2019 Annual (UT Health- San Antonio) President’s Luncheon “Why We Do What We Do”. Aune Lab
May 17, 2019
M. Gorelik Y. Lee M. Abe T. Andrews L. Davis J. Patterson S. Chen T. R. Crother G. J. Aune M. Noval Rivas M. Arditi Summary Kawasaki disease (KD) vasculitis is an acute febrile illness of childhood characterized by systemic vasculitis of unknown origin and is the most common cause of acquired heart disease among children in the United States. While histological […]
May 15, 2019
Merit L Goodman 1 2 3, Gloria M Trinca 1 2 3, Katherine R Walter 1 2 3, Evangelia K Papachristou 4, Clive S D’Santos 4, Tianbao Li 5, Qi Liu 5, Zhao Lai 5 6, Prabhakar Chalise 7, Rashna Madan 8, Fang Fan 8, Mary A Markiewicz 9, Victor X Jin 5, Jason S Carroll 4, Christy R Hagan 10 2 3 Abstract Why some tumors remain indolent and others progress to clinical relevance remains a major unanswered question in cancer biology. IFN signaling in nascent tumors, mediated by STAT1, is a […]
May 2, 2019
Author links open overlay panelSuhasVasaikar1214ChenHuang1214XiaojingWang121214Vladislav A.Petyuk314Sara R.Savage414BoWen12YongchaoDou12YunZhang1ZhiaoShi12Osama A.Arshad3Marina A.Gritsenko3Lisa J.Zimmerman5Jason E.McDermott3Therese R.Clauss3Ronald J.Moore3RuiZhao3Matthew E.Monroe3Yi-TingWang3Matthew C.Chambers5Robbert J.C.Slebos5Ken S.Lau6QianxingMo713LiDing8MatthewEllis17MathangiThiagarajan9Christopher R.Kinsinger10HenryRodriguez10Richard D.Smith3Karin D.Rodland31115Daniel C.Liebler515TaoLiu315BingZhang1271516 We performed the first proteogenomic study on a prospectively collected colon cancer cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal adjacent tissues produced a catalog of colon cancer-associated proteins and phosphosites, […]
May 1, 2019
Siyuan Zheng, Kristin Alfaro-Munoz, Wei Wei, Xiaojing Wang, Fang Wang, Agda Karina Eterovic, Kenna R Mills Shaw, Funda Meric-Bernstam, Gregory N Fuller, Ken Chen, Roel G Verhaak, Gordon B Mills, WK Alfred Yung, Shiao-Pei Weathers, John F de Groot Malignant gliomas are a group of intracranial cancers associated with disproportionately high mortality and morbidity. Here, […]