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Alex’s Lemonade Stand: The Crazy 8 Initiative Topics & Teams
October 1, 2018
ALSF launched the Crazy 8 Initiative to detail roadmaps toward cures for specific, hard-to-treat childhood cancers. This collaborative effort kicked off in the fall of 2018 with a meeting that brought together more than 90 top scientists from around the world providing expertise in eight key areas of need.
American Journal of Surgery: Polytrauma independent of therapeutic intervention alters the gastrointestinal microbiome
October 1, 2018
Susannah E Nicholson 1, Daniel Merrill 2, Caroline Zhu 3, David M Burmeister 4, Yi Zou 5, Zhao Lai 6, Daniel N Darlington 7, Aaron M Lewis 8, Larry Newton 9, Shannon Scroggins 10, Brian J Eastridge 11, Martin G Schwacha 12 Abstract Background: This study characterizes the gastrointestinal (GI) microbiome in a pre-clinical polytrauma hemorrhage model. Methods: Rats (n = 6) were anesthetized, hemorrhaged 20% of their blood volume, and subjected to a femur fracture and crush injuries to […]
YouTube: Children’s Cause, Challenges in Clinical Trial Design
September 18, 2018
CHILDHOOD CANCER HEARING LOSS AN EXTERNALLY-LED PATIENT-FOCUSED DRUG DEVELOPMENT WORKSHOP: CHEMOTHERAPY-INDUCED HEARING LOSS IN PEDIATRIC ONCOLOGY 3:25-3:35 Challenges in Clinical Trial Design in Chemotherapy-Induced Hearing Loss | Greg Aune, MD, PhD, Assistant Professor, UT Health San Antonio-Greehey Children’s Cancer Research Institute The half-day meeting follows the FDA model for externally-led PFDD meetings and will feature […]
Oncology: Immunogenic Heterogeneity of Renal Cell Carcinoma With Venous Tumor Thrombus
September 18, 2018
Author links open overlay panelMichael A.Lissabcd YidongChenabcd RonaldRodriguezabcd DeepakPruthiabcd TeresaJohnson-PaisabcdHanzhangWangabcd AhmedMansourabcd DharamKaushikabcd Abstract Objective To perform immune-cell enumeration and programmed death-ligand 1 (PD-L1) expression in clear cell renal cell carcinoma (cc-RCC) with tumor thrombus (TT) to guide therapeutic decisions. Methods After obtaining IRB approval and surgical consent, 6 patients underwent radical nephrectomy with venous tumor thrombectomy. We utilized RNA Sequencing to obtain RNAseq expression profiles. Computational […]
Childhood Cancer Hearing Loss PFDD Meeting (Full Program)
September 13, 2018
The pediatric patient population with chemotherapy-induced hearing loss represents a segment of the cancer survivor community with a severe burden of disease with a great unmet medical need. An externally-led, FDA-approved Patient-Focused Drug Development (PFDD) meeting on September 13, 2018, near Washington, DC will explore these issues in-depth. The half-day meeting follows the FDA model […]
Elife: tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish
September 7, 2018
Myron S Ignatius # 1 2 3 4, Madeline N Hayes # 1 2 3, Finola E Moore 1 2 3, Qin Tang 1 2 3, Sara P Garcia 1, Patrick R Blackburn 5, Kunal Baxi 4, Long Wang 4, Alexander Jin 1, Ashwin Ramakrishnan 1, Sophia Reeder 1, Yidong Chen 4, Gunnlaugur Petur Nielsen 1 2, Eleanor Y Chen 6, Robert P Hasserjian 1 2, Franck Tirode 7, Stephen C Ekker 8, David M Langenau 1 2 3 Abstract The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germline inactivation are predisposed to developing cancer. Here, we generated tp53 deleted […]
eLife: tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish
September 7, 2018
Myron S Ignatius, Madeline N Hayes, Finola E Moore, Qin Tang, Sara P Garcia, Patrick R Blackburn, Kunal Baxi, Long Wang, Alexander Jin, Ashwin Ramakrishnan, Sophia Reeder, Yidong Chen, Gunnlaugur Petur Nielsen, Eleanor Y Chen, Robert P Hasserjian, Franck Tirode, Stephen C Ekker, David M Langenau Abstract The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germline inactivation are predisposed to developing cancer. Here, we generated tp53 deleted […]
JCI Insight: IL-6 and CXCL8 mediate osteosarcoma-lung interactions critical to metastasis
August 23, 2018
Amy C. Gross,1 Hakan Cam,1,2 Doris A. Phelps,3 Amanda J. Saraf,2,4 Hemant K. Bid,1,2 Maren Cam,1 Cheryl A. London,5,6 Sarah A. Winget,1 Michael A. Arnold,7,8 Laura Brandolini,9 Xiaokui Mo,10 John M. Hinckley,1,11 Peter J. Houghton,3 and Ryan D. Roberts1,2,4 Abstract: Osteosarcoma (OS), a malignant tumor of bone, kills through aggressive metastatic spread almost exclusively to the lung. Mechanisms driving this tropism for lung tissue remain unknown, though likely invoke […]
UT Health SA Newsroom: CPRIT awards millions to UT Health San Antonio
August 18, 2018
Cancer prevention programs and initiatives to recruit faculty to UT Health San Antonio got a $3.5 million boost from the Cancer Prevention & Research Institute of Texas (CPRIT). The awards, announced Aug. 16, bringing total funding to UT Health San Antonio by CPRIT to about $74.6 million since the program began in 2008. The Mays […]