Oncotarget: LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer

July 3, 2018

Liqin Du1, Zhenze Zhao1, Milind Suraokar2, Spencer S. Shelton1, Xiuye Ma3, Tzu-Hung Hsiao4, John D. Minna5, Ignacio Wistuba2,6 and Alexander Pertsemlidis3,7 ABSTRACT LMO1 encodes a protein containing a cysteine-rich LIM domain involved in protein-protein interactions. Recent studies have shown that LMO1 functions as an oncogene in several cancer types, including non-small cell lung cancer (NSCLC). However, […]

Cancer Letters: Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells

July 1, 2018

AlfeuZanotto-Filhoac  SubapriyaRajamanickama  EvaLoranca  V. Pragathi Masamsettia  AparnaGorthiab  July CarolinaRomeroab  SonalTonapiab  Rosangela Mayer Gonçalvesc  Robert L.Reddickd  RaymondBenavidese  JohnKuhnde  YidongChenf  Alexander J.R.Bishopab Abstract Molecularly targeted compounds are emerging as a strategy to improve classical chemotherapy. Herein, we describe that using a low dose of the multikinase inhibitor sorafenib improves cyclophosphamide antitumor activity by inhibiting angiogenesis, metastasis, and promoting tumor healing in MDA-MB231 xenografts and the 4T1-12B syngeneic breast […]

The Journal of Physical Chemistry Letters: Extensive Sampling of the Cavity of the GroEL Nanomachine by Protein Substrates Probed by Paramagnetic Relaxation Enhancement

June 21, 2018

Marielle A Wälti 1, David S Libich 1, G Marius Clore 1 Abstract The chaperonin GroEL is an 800 kDa nanomachine comprising two heptameric rings, each of which encloses a large cavity or folding chamber. The GroEL cycle involves ATP-dependent capping of the cavity by the cochaperone GroES to create a nanocage in which a single protein molecule can fold. […]

Cancer Research: Differential Effects of Estrogen Receptor β Isoforms on Glioblastoma Progression

June 15, 2018

Jinyou Liu # 1 2, Gangadhara R Sareddy # 1 3, Mei Zhou 1 4, Suryavathi Viswanadhapalli 1, Xiaonan Li 1, Zhao Lai 5, Rajeshwar R Tekmal 1 3, Andrew Brenner 3 6, Ratna K Vadlamudi 7 3 Abstract The estrogen receptor β (ERβ) functions as a tumor suppressor in glioblastoma (GBM) cells. However, the in vivo significance of endogenous ERβ and the roles of its isoforms in GBM are incompletely understood. Using ERβ isoform-specific PCR screening, we found that GBM cells […]

Express-News: STAR Act is a victory for children with cancer

June 13, 2018

Express-News: STAR Act is a victory for children with cancer Published On: June 13, 2018 Shared by contributor By Gregory J. Aune, MD, PhD For the Express-News President Donald Trump’s signing of the Childhood Cancer Survivorship, Treatment, Access, and Research, or STAR, Act on Tuesday represents a significant legislative achievement in the ongoing battle to improve outcomes […]

International Journal of Genomics: Noncoding RNAs and Base Modifications: Epigenomic Players Implicated in Neurological Disorders and Tumorigenesis

June 13, 2018

Zhen Wei,1,2 Subbarayalu Panneerdoss,3,4 Santosh Timilsina,3,4 Jingting Zhu,1,5 Tabrez A. Mohammad,3 Zhi-Liang Lu,1,5 João Pedro de Magalhães,2 Yidong Chen,3,6 Rong Rong,1,5 Yufei Huang,6,7 Manjeet K. Rao,3,4 and Jia Meng1,5 Abstract Background. Compared with the well-studied 5-methylcytosine (m5C) in DNA, the role and topology of epitranscriptome m5C remain insufficiently characterized. Results. By analyzing transcriptome-wide m5C distribution in humans and mice, we show that the m5C modification is significantly enriched […]

Fraternal Order of Eagles: People Helping People

May 18, 2018

2016-17 Texas State Presidents Ron Poling and Rachel Graham were proud to present a check for $50,000 to Dr. Houghton, Director of the Greehey Children’s Cancer Research Institute at the University of Texas Health Science Center in San Antonio. Ron and Rachel would like to thank all the Texas State Aerie and Auxiliary members for […]

Nature Genetics: Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

April 23, 2018

Ana C deCarvalho 1, Hoon Kim 2, Laila M Poisson 3, Mary E Winn 4, Claudius Mueller 5, David Cherba 4, Julie Koeman 6, Sahil Seth 7, Alexei Protopopov 7, Michelle Felicella 8, Siyuan Zheng 9, Asha Multani 10, Yongying Jiang 7, Jianhua Zhang 7, Do-Hyun Nam 11 12 13, Emanuel F Petricoin 5, Lynda Chin 7 9, Tom Mikkelsen 14 15, Roel G W Verhaak 16 Abstract To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft […]