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January 31, 2019
Study of 28,000 childhood cancer survivors finds important differences In long-term survivors of childhood cancer, cardiovascular disease is a leading cause of early death from non-cancer causes. In a new study, published Jan. 31 in JAMA Oncology, researchers compared four chemotherapy drugs with the development of cardiomyopathy (abnormal heart muscle with impaired function) years after treatment.
January 31, 2019
Yu-Chiao Chiu, Hung-I Harry Chen, Tinghe Zhang, Songyao Zhang, Aparna Gorthi, Li-Ju Wang, Yufei Huang & Yidong Chen Abstract Background The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insights into the oncogenic features modulating drug response. A recent study screened for the response of a thousand human cancer cell lines to a wide collection of anti-cancer drugs and […]
January 31, 2019
https://vimeo.com/314646779 “Moderator: Dr. Len Lichtenfeld, MD, Deputy Chief Medical Officer, American Cancer Society Mary Tankersley, Survivor, Rally Foundation Ambassador Dr. Greg Aune, MD, PhD, Pediatric Oncologist, Greehey Children’s Cancer Research Hospital Hon. Lee Satterfield, JD, Former Chief Judge, DC Superior Court Dr. Joshua Schiffman, MD, Professor of Pediatric Hematology/Oncology and Adjunct Professor of Oncological Sciences, Huntsman Cancer Center, University […]
January 31, 2019
Elizabeth A. M. Feijen, PhD1,2; Wendy M. Leisenring, ScD3,4; Kayla L. Stratton, MS3,4; Kirsten K. Ness, PT, PhD5; Helena J. H. van der Pal, MD, PhD2; Elvira C. van Dalen, MD, PhD1,2; Gregory T. Armstrong, MD, MSCE5; Gregory J. Aune, MD, PhD6; Daniel M. Green, MD5; Melissa M. Hudson, MD7; Jacqueline Loonen, MD, PhD8; Kevin C. Oeffinger, MD9; Leslie L. Robison, PhD5; Yutaka Yasui, PhD5; Leontien C. M. Kremer, MD, PhD1,2; Eric J. Chow, MD, MPH3,4,10 Abstract Importance Anthracyclines are part of many effective pediatric cancer treatment protocols. Most pediatric oncology treatment groups assume that the hematologic toxicity of anthracycline agents is equivalent […]
January 21, 2019
SAN ANTONIO — In long-term survivors of childhood cancer, cardiovascular disease is a leading cause of early death from non-cancer causes. In a new study, published Jan. 31 in JAMA Oncology, researchers compared four chemotherapy drugs with the development of cardiomyopathy (abnormal heart muscle with impaired function) years after treatment.
January 15, 2019
Yohei Niikura 1,2,* Risa Kitagawa 1 and Katsumi Kitagawa 1,* Abstract The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centromere protein A (CENP-A), in centromeric nucleosomes. However, the precise mechanisms of deposition, maintenance, and inheritance of CENP-A at […]
January 2, 2019
Song-Yao Zhang, Shao-Wu Zhang, Xiao-Nan Fan, Jia Meng, Yidong Chen, Shou-Jiang Gao, Yufei Huang Abstract N6-methyladenosine (m6A) is the most abundant methylation, existing in >25% of human mRNAs. Exciting recent discoveries indicate the close involvement of m6A in regulating many different aspects of mRNA metabolism and diseases like cancer. However, our current knowledge about how m6A levels are controlled and […]
December 21, 2018
Hung-I Harry Chen, Yu-Chiao Chiu, Tinghe Zhang, Songyao Zhang, Yufei Huang & Yidong Chen Abstract Background Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set-based analyses improve the biologists’ capability to discover the functional relevance of their experiment design. While elucidating gene set individually, inter-gene sets association is rarely taken into […]
December 21, 2018
Yu-Chiao Chiu, Tzu-Hung Hsiao, Li-Ju Wang, Yidong Chen & Yu-Hsuan Joni Shao Abstract Background Single-cell RNA sequencing (scRNA-Seq) is an emerging technology that has revolutionized the research of tumor heterogeneity. However, the highly sparse data matrices generated by the technology have posed an obstacle to the analysis of differential gene regulatory networks. Results Addressing the challenges, this study presents, as […]
December 14, 2018
Zhenze Zhao, Veronica Partridge, Michaela Sousares, Spencer D. Shelton, Cory L. Holland, Alexander Pertsemlidis, Liqin Du Abstract microRNA-2110 (miR-2110) was previously identified as inducing neurite outgrowth in neuroblastoma cell lines BE(2)-C, suggesting its differentiation-inducing and oncosuppressive function in neuroblastoma. In this study, we demonstrated that synthetic miR-2110 mimic had a generic effect on reducing cell […]