European Urology: Metabolic Biosynthesis Pathways Identified from Fecal Microbiome Associated with Prostate Cancer

November 1, 2018

Michael A Liss 1, James Robert White 2, Martin Goros 3, Jonathan Gelfond 3, Robin Leach 4, Teresa Johnson-Pais 4, Zhao Lai 5, Elizabeth Rourke 4, Joseph Basler 4, Donna Ankerst 4, Dimpy P Shah 3 Abstract Background: The fecal microbiome is associated with prostate cancer risk factors (obesity, inflammation) and can metabolize and produce various products that may influence cancer but have yet to be defined in prostate cancer. Objective: To investigate gut bacterial diversity, identify specific […]

Nature Communications: MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

October 31, 2018

Nourhan Abdelfattah, Subapriya Rajamanickam, Subbarayalu Panneerdoss, Santosh Timilsina, Pooja Yadav, Benjamin C. Onyeagucha, Michael Garcia, Ratna Vadlamudi, Yidong Chen, Andrew Brenner, Peter Houghton & Manjeet K. Rao Abstract Despite improvements in overall survival, only a modest percentage of patients survive high-risk medulloblastoma. The devastating side effects of radiation and chemotherapy substantially reduce the quality of life for surviving patients. Here, using genomic screens, we identified miR-584-5p as a […]

International Journal of Oncology: Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma

October 5, 2018

Jorge De La Chapa, Prajjal Kanti Singha, Mckay Sallaway, Kristen Self, Ranna  Nasreldin, Ramesh Dasari, Matthew Hart., Alexander Kornienko, Jeremy  Just, Jason A. Smith, Alex C. Bissember, Cara B. Gonzales Abstract Polygodial, a drimane sesquiterpenoid dialdehyde isolated as a pungent component of the water pepper Persicaria hydropiper, exhibits antifeedant, antimicrobial, anti-inflammatory, and anticancer effects. Polygodial also activates transient receptor potential vanilloid subtype 1 (TRPV1) […]

Science Advances: Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression

October 3, 2018

Subbarayalu Panneerdoss1,2,*, Vijay K. Eedunuri1,2,*, Pooja Yadav1,2, Santosh Timilsina1,2, Subapriya Rajamanickam2,3, Suryavathi Viswanadhapalli4, View ORCID ProfileNourhan Abdelfattah1,2, Benjamin C. Onyeagucha1,2, View ORCID ProfileXiadong Cui5, Zhao Lai2, View ORCID ProfileTabrez A. Mohammad2, View ORCID ProfileYogesh K. Gupta2,6, Tim Hui-Ming uang3, Yufei Huang5,†, View ORCID ProfileYidong Chen2,7,† and View ORCID ProfileManjeet K. Rao1,2,† Abstract The importance of RNA methylation in biological processes is an emerging focus of the investigation. We report that altering […]

Alex’s Lemonade Stand: The Crazy 8 Initiative Topics & Teams

October 1, 2018

ALSF launched the Crazy 8 Initiative to detail roadmaps toward cures for specific, hard-to-treat childhood cancers. This collaborative effort kicked off in the fall of 2018 with a meeting that brought together more than 90 top scientists from around the world providing expertise in eight key areas of need.

American Journal of Surgery: Polytrauma independent of therapeutic intervention alters the gastrointestinal microbiome

October 1, 2018

Susannah E Nicholson 1, Daniel Merrill 2, Caroline Zhu 3, David M Burmeister 4, Yi Zou 5, Zhao Lai 6, Daniel N Darlington 7, Aaron M Lewis 8, Larry Newton 9, Shannon Scroggins 10, Brian J Eastridge 11, Martin G Schwacha 12 Abstract Background: This study characterizes the gastrointestinal (GI) microbiome in a pre-clinical polytrauma hemorrhage model. Methods: Rats (n = 6) were anesthetized, hemorrhaged 20% of their blood volume, and subjected to a femur fracture and crush injuries to […]

YouTube: Children’s Cause, Challenges in Clinical Trial Design

September 18, 2018

CHILDHOOD CANCER HEARING LOSS AN EXTERNALLY-LED PATIENT-FOCUSED DRUG DEVELOPMENT WORKSHOP: CHEMOTHERAPY-INDUCED HEARING LOSS IN PEDIATRIC ONCOLOGY 3:25-3:35 Challenges in Clinical Trial Design in Chemotherapy-Induced Hearing Loss | Greg Aune, MD, PhD, Assistant Professor, UT Health San Antonio-Greehey Children’s Cancer Research Institute The half-day meeting follows the FDA model for externally-led PFDD meetings and will feature […]

Oncology: Immunogenic Heterogeneity of Renal Cell Carcinoma With Venous Tumor Thrombus

September 18, 2018

Author links open overlay panelMichael A.Lissabcd  YidongChenabcd  RonaldRodriguezabcd  DeepakPruthiabcd  TeresaJohnson-PaisabcdHanzhangWangabcd  AhmedMansourabcd  DharamKaushikabcd Abstract Objective To perform immune-cell enumeration and programmed death-ligand 1 (PD-L1) expression in clear cell renal cell carcinoma (cc-RCC) with tumor thrombus (TT) to guide therapeutic decisions. Methods After obtaining IRB approval and surgical consent, 6 patients underwent radical nephrectomy with venous tumor thrombectomy. We utilized RNA Sequencing to obtain RNAseq expression profiles. Computational […]

Childhood Cancer Hearing Loss PFDD Meeting (Full Program)

September 13, 2018

The pediatric patient population with chemotherapy-induced hearing loss represents a segment of the cancer survivor community with a severe burden of disease with a great unmet medical need. An externally-led, FDA-approved Patient-Focused Drug Development (PFDD) meeting on September 13, 2018, near Washington, DC will explore these issues in-depth. The half-day meeting follows the FDA model […]

Elife: tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

September 7, 2018

Myron S Ignatius # 1 2 3 4, Madeline N Hayes # 1 2 3, Finola E Moore 1 2 3, Qin Tang 1 2 3, Sara P Garcia 1, Patrick R Blackburn 5, Kunal Baxi 4, Long Wang 4, Alexander Jin 1, Ashwin Ramakrishnan 1, Sophia Reeder 1, Yidong Chen 4, Gunnlaugur Petur Nielsen 1 2, Eleanor Y Chen 6, Robert P Hasserjian 1 2, Franck Tirode 7, Stephen C Ekker 8, David M Langenau 1 2 3 Abstract The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germline inactivation are predisposed to developing cancer. Here, we generated tp53 deleted […]