Europe PMC: Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis.

September 15, 2016

Zanotto-Filho A1, Masamsetti VP1, Loranc E1, Tonapi SS1, Gorthi A1, Bernard X1, Gonçalves RM2, Moreira JC2, Chen Y1, Bishop AJ1 Abstract  Alkylating agents are a commonly used cytotoxic class of anticancer drugs. Understanding the mechanisms whereby cells respond to these drugs is key to identify means to improve therapy while reducing toxicity. By integrating genome-wide gene […]

European Journal of Medicinal Chemistry: 5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

September 14, 2016

Author links open overlay panelAuthor links open overlay panelSean Henrya\, Ria Kidnera, Mary R.Reisenauera, Igor V .Magedova, Robert Kissb, Véronique Mathieub, Florence Lefrancc, Ramesh Dasarid, Antonio Evidentee, Xiaojie Yuf, Xiuye Maf, Alexander Pertsemlidisf, Regina Cencicg, Jerry Pelletierg, David A.Cavazosh, Andrew J.Brennerh, Alexander V.Aksenovi, SneznaRogelja, Liliya V.Frolovaa Abstract Plants of the Amaryllidaceae family produce a large variety of alkaloids and […]

Hyundai Hope on Wheels Awards $250,000 Research Grant to Ut Health Science Center San Antonio in Honor of National Childhood Cancer Awareness Month

September 12, 2016

San Antonio, TX – September 12 – Hyundai Hope On Wheels® (HHOW) and San Antonio-area Hyundai dealers will present UT Health Science Center San Antonio with a $250,000 Scholar Grant to be used to improve care and increase treatment options for kids with cancer. UT Health Science Center San Antonio was one of 24 recipients across the […]

The American Journal of Pathology: Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit

September 1, 2016

The conserved RNA-binding protein Musashi1 (MSI1) has been characterized as a stem cell marker, controlling the balance between self-renewal and differentiation and as a key oncogenic factor in numerous solid tumors, including glioblastoma. To explore the potential use of MSI1 targeting in therapy, we studied MSI1 in the context of radiation sensitivity. The knockdown of […]

BMC Genomics: Detection of high variability in gene expression from single-cell RNA-seq profiling

August 22, 2016

Hung-I Harry Chen, Yufang Jin, Yufei Huang & Yidong Chen Abstract Background The advancement of the next-generation sequencing technology enables mapping gene expression at the single-cell level, capable of tracking cell heterogeneity and determination of cell subpopulations using single-cell RNA sequencing (scRNA-seq). Unlike the objectives of conventional RNA-seq where differential expression analysis is the integral component, the most important […]

BMC Genomics: A hierarchical model for clustering m6A methylation peaks in MeRIP-seq data

August 22, 2016

Xiaodong Cui, Jia Meng, Shaowu Zhang, Manjeet K. Rao, Yidong Chen & Yufei Huang Abstract Background The recent advent of the state-of-art high throughput sequencing technology, known as Methylated RNA Immunoprecipitation combined with RNA sequencing (MeRIP-seq) revolutionizes the area of mRNA epigenetics and enables the biologists and biomedical researchers to have a global view of N 6-Methyladenosine (m6A) on the transcriptome. Yet there […]

BMC Genomics: CrossLink: a novel method for cross-condition classification of cancer subtypes

August 22, 2016

Chifeng Ma, Konduru S. Sastry, Mario Flore, Salah Gehani, Issam Al-Bozom, Yusheng Feng, Erchin Serpedin, Lotfi Chouchane, Yidong Chen & Yufei Huang Abstract Background We considered the prediction of cancer classes (e.g. subtypes) using patient gene expression profiles that contain both systematic and condition-specific biases when compared with the training reference dataset. The conventional normalization-based approaches cannot guarantee that the gene signatures in the reference […]

BMC Genomics: MBDDiff: an R package designed specifically for processing MBDcap-seq datasets

August 18, 2016

Yuanhang Liu,  Desiree Wilson,  Robin J. Leach   Yidong Chen  Abstract Background Since its initial discovery in 1975, DNA methylation has been intensively studied and shown to be involved in various biological processes, such as development, aging, and tumor progression. Many experimental techniques have been developed to measure the level of DNA methylation. Methyl-CpG binding […]

San Antonio Report: Commentary: Are Questions More Powerful Than Answers?

July 23, 2016

In the afternoon, the students had an opportunity to meet with Dr. Alexander Pertsemlidis, associate professor of pediatrics, hematology, and oncology at the Greehey Children’s Cancer Research Institute at the University of Texas Health Science Center. Dr. Pertsemlidis is paving the way for new cancer treatments for patients and survivors with cutting-edge research. The students visited the lab to get […]

San Antonio Business Journal: SA biotech company and Health Science Center to use the power of collaboration to combat cancer

July 13, 2016

One of San Antonio’s more promising bioscience companies, bioAffinity Technologies Inc., has locked up a key deal, renewing its collaborative agreement with the University of Texas Health Science Center at San Antonio. The extension will allow the two organizations to continue working together on the research and development of novel cancer diagnostic and therapeutic agents […]