Hepatology: A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH)

June 13, 2017

Jyoti Srivastava 1, Chadia L Robertson 1, Kareem Ebeid 2, Mikhail Dozmorov 3, Devaraja Rajasekaran 1, Rachel Mendoza 1, Ayesha Siddiq 1, Maaged A Akiel 1, Nidhi Jariwala 1, Xue-Ning Shen 1, Jolene J Windle 1, Mark A Subler 1, Nitai D Mukhopadhyay 3, Shah Giashuddin 4, Shobha Ghosh 5, Zhao Lai 6, Yidong Chen 7, Paul B Fisher 1 8 9, Aliasger K Salem 2 10, Arun J Sanyal 5, Devanand Sarkar 1 8 9 Abstract Nonalcoholic steatohepatitis (NASH) is the most prevalent cause of chronic liver disease in the Western world. However, an optimum therapy for NASH is yet […]

Cancer Knowledge Network: Mental Distress in Survivors: Highly Prevalent and Undertreated

June 8, 2017

Cancer:  Mental distress and health care use among survivors of adolescent and young adult cancer:  A cross-sectional analysis of the National Health Interview Survey. 875 adolescent and young adult cancer survivors were identified from the 2013 and 2014 National Health Interview Survey. This survey is the principal source of information on the overall health status […]

Cancer Knowledge Network: Childhood Cancer Survivors: Does chemotherapy alone increase second cancer risk?

June 1, 2017

THE RESEARCH: Journal of Clinical Oncology: Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy.  Researchers in the Netherlands identified second cancers in 5-year childhood cancer survivors in the Dutch Childhood Cancer Oncology Group Long-Term Effects After Childhood Cancer (DCOG LATER) cohort. Cumulative incidences of breast […]

JAMA Oncology: Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era: A Correlative Analysis Based on NRG Oncology RTOG 0525

June 1, 2017

Erica Hlavin Bell 1, Stephanie L Pugh 2, Joseph P McElroy 3, Mark R Gilbert 4, Minesh Mehta 5, Alexander C Klimowicz 6, Anthony Magliocco 7, Markus Bredel 8, Pierre Robe 9, Anca-L Grosu 10, Roger Stupp 11, Walter Curran Jr 12, Aline P Becker 1, Andrea L Salavaggione 1, Jill S Barnholtz-Sloan 13, Kenneth Aldape 14, Deborah T Blumenthal 15, Paul D Brown 14, Jon Glass 16, Luis Souhami 17, R Jeffrey Lee 18, David Brachman 19, John Flickinger 20, Minhee Won 2, Arnab Chakravarti 1 Abstract Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in […]

Aging Cell: Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health

May 29, 2017

Ning Zhang 1, Joseph M Valentine 1, You Zhou 1, Mengyao E Li 1 2, Yiqiang Zhang 1, Arunabh Bhattacharya 1, Michael E Walsh 1, Katherine E Fischer 1, Steven N Austad 1, Pawel Osmulski 1, Maria Gaczynska 1, Steven E Shoelson 2, Holly Van Remmen 1, Hung I Chen 3 4, Yidong Chen 3 4, Hanyu Liang 1, Nicolas Musi 1 5 Abstract Older adults universally suffer from sarcopenia and approximately 60-70% are diabetic or prediabetic. Nonetheless, the mechanisms underlying these aging-related metabolic disorders are unknown. NFκB has been implicated in […]

Cancer Knowledge Network: First Live Births Less Common in Cancer Survivors

May 25, 2017

THE RESEARCH: Journal of Clinical Oncology:  Reproductive Patterns Among Childhood and Adolescent Cancer Survivors in Sweden: A Population-Based Matched-Cohort Study. Researchers in Sweden compared the probability of first live birth in 1,206 survivors of childhood cancers with 2,412 age-matched controls.  Previous studies assessing fertility outcomes in childhood cancer survivors have focused on treatment regimens, as […]

Nature: The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution

May 22, 2017

Hélène Badouin, Jérôme Gouzy, Christopher J. Grassa, Florent Murat, S. Evan Staton, Ludovic Cottret, Christine Lelandais-Brière, Gregory L. Owens, Sébastien Carrère, Baptiste Mayjonade, Ludovic Legrand, Navdeep Gill, Nolan C. Kane, John E. Bowers, Sariel Hubner, Arnaud Bellec, Aurélie érard, Hélène Bergès, Nicolas Blanchet, Marie-Claude Boniface, Dominique Brunel, Olivier Catrice, Nadia Chaidir, Clotilde Claudel, Cécile Donnadieu, Thomas Faraut, Ghislain Fievet, Nicolas Helmstetter, Matthew King, Steven J. Knapp, Zhao Lai, Marie-Christine Le Paslier, Yannick Lippi, Lolita Lorenzon, Jennifer R. Mandel, Gwenola Marage, Gwenaëlle Marchand, Elodie Marquand, Emmanuelle Bret-Mestries, Evan Morien, Savithri Nambeesan, Thuy Nguyen, Prune Pegot-Espagnet, Nicolas Pouilly, Frances Raftis, Erika Sallet, Thomas […]

Cancer Knowledge Network: Hodgkin Lymphoma Survivors at High Risk of Second Cancers

May 18, 2017

THE RESEARCH: The Journal of Clinical Oncology:  Risk of Second Cancer in Hodgkin Lymphoma Survivors and the Influence of Family History.  Researchers in the European countries of the United Kingdom, Germany, and Sweden collaborated to study rates of secondary cancers in 9,522 Hodgkin lymphoma (HL) survivors identified in the Swedish Family-Cancer Project Database.  The researchers […]

Cancer Knowledge Network: What Factors are Associated with Hearing Loss in Childhood Cancer Survivors Treated with Platinum Agents?

May 4, 2017

THE RESEARCH:  Determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer:  A DCOG late-effects study.  Researchers compiled treatment data and audiograms from 451 childhood cancer survivors (CCS) treated at seven pediatric oncology centers in the Netherlands.  The study focused on identifying patients that had received platinum agents without cranial irradiation since no previous studies […]