DNA Repair: p21 controls patterning but not homologous recombination in RPE development

August 15, 2005

Author links open overlay panelA.J.R.Bishopa  B.Kosarasb M.C.Hollanderc A.FornaceJr.c R.L.Sidmanb R.H.Schiestld Abstract p21/WAF1/CIP1/MDA6 is a key cell cycle regulator. Cell cycle regulation is an important part of development, differentiation, DNA repair, and apoptosis. Following DNA damage, p53 dependent expression of p21 results in a rapid cell cycle arrest. p21 also appears to be important for the […]