Clinical Cancer Research: Update on Surveillance for Wilms Tumor and Hepatoblastoma in Beckwith–Wiedemann Syndrome and Other Predisposition Syndromes (Tomlinson)

December 2, 2024

Update on Surveillance for Wilms Tumor and Hepatoblastoma in Beckwith–Wiedemann Syndrome and Other Predisposition Syndromes Jennifer M. Kalish Kerri D. Becktell Gaëlle Bougeard Garrett M. Brodeur Lisa R. Diller Andrea S. Doria Jordan R. Hansford Steven D. Klein Wendy K. Kohlmann Christian P. Kratz Suzanne P. MacFarland Kristian W. Pajtler Surya P. Rednam Jaclyn Schienda [...]

SLAS Discovery: The History, Landscape, and Outlook of Human Cell Line Authentication and Security (Pertsemlidis)

November 20, 2024

Elijah Harbut1,2,3 ∙ Yiorgos Makris4 ∙ Alexander Pertsemlidis5,6,7 ∙ Leonidas Bleris1,2,3 1 Introduction The phenomenon of cellular cross-contamination and misidentification (“CCCM”) was identified more than six decades ago and continues to pose significant challenges for laboratories globally. The prevalence of CCCM is alarmingly high, with estimates suggesting that up to 30% of cell lines may be misidentified, leading to substantial financial losses[2–4]. Accelerating progress in [...]

Molecular Cancer Therapeutics: Abstract B016: RNA demethylase ALKBH5 drives medulloblastoma growth and progression (Rao, Chen, Gupta, & Houghton Labs)

November 18, 2024

Panneerdoss Subbarayalu; Daisy Medina; Pitta Prabhakar; Shahad Abdulsahib; Saif Nirzhor; Desiree Denman; Santosh Timilsina; Deepika Singh; Phat Do; Krishna Evani; Dhiya Billa; Esha Reddy; Peter Houghton; Yogesh Gupta; Yidong Chen; Suryavathi Viswanadhapalli; Ratna Vadlamudi; Andrew Brenner; Manjeet Rao Abstract Introduction: Medulloblastoma (MB) is the most common malignant childhood brain tumor. It accounts for 20% of [...]

Molecular Oncology: Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma (Libich Lab)

October 3, 2024

Erich J. Sohn, David S. Libich Abstract Ewing sarcoma, an aggressive pediatric cancer, is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF chromatin remodeling complex. Central to this mechanism is the formation of biomolecular condensates, mediated by the prion-like domains (PrLDs) of EWS and ARID1A, a core BAF subunit. ARID1A serves [...]

Vaccines: Pediatric Oncology Providers’ HPV Vaccine Knowledge, Attitude, Self-Efficacy, and Practice after Communication Training: A Comparison with a National Survey (Grimes)

October 3, 2024

Rejane A. Teixeira ,Allison Grimes,Leanne Embry,Christine Aguilar, L. Aubree Shay Abstract Background/Objectives: Human papillomavirus (HPV) vaccinations prevent HPV infection and related cancers. Despite being at higher risk of secondary cancers linked to HPV, childhood cancer survivors (CCS) are under-vaccinated. This study aimed to compare pediatric oncology providers’ knowledge, attitudes, self-efficacy, and practices regarding HPV vaccination [...]

Pigment Cell & Melanoma: Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation (Lai Lab)

September 25, 2024

Erika Soria, Qiusheng Lu, Will Boswell, Kang Du, Yanting Xing, Mikki Boswell, Korri S. Weldon, Zhao Lai, Markita Savage, Manfred Schartl, Yuan Lu ABSTRACT Genetic interactions are adaptive within a species. Hybridization can disrupt such species-specific genetic interactions and creates novel interactions that alter the hybrid progeny overall fitness. Hybrid incompatibility, which refers to degenerative genetic interactions that decrease the overall hybrid survival and sterility, is [...]

Nature: Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination (Sung, Libich)

September 12, 2024

Sameer Salunkhe, James M. Daley, Hardeep Kaur, Nozomi Tomimatsu, Chaoyou Xue, Vivek B. Raina, Angela M. Jasper, Cody M. Rogers, Wenjing Li, Shuo Zhou, Rahul Mojidra, Youngho Kwon, Qingming Fang, Jae-Hoon Ji, Aida Badamchi Shabestari, O’Taveon Fitzgerald, Hoang Dinh, Bipasha Mukherjee, Amyn A. Habib, Robert Hromas, Alexander V. Mazin, Elizabeth V. Wasmuth, Shaun K. Olsen, [...]

Journal of the National Cancer Institute: Integrative multi-omics characterization of hepatocellular carcinoma in Hispanic patients (Zheng, Chen & Lai Labs)

September 4, 2024

Debodipta Das, PhD, Xiaojing Wang, PhD, Yu-Chiao Chiu, PhD, Hakim Bouamar, PhD, Francis E Sharkey, MD, Jorge E Lopera, MD, Zhao Lai, PhD, Susan T Weintraub, PhD, Xianlin Han, PhD, Yi Zou, MS, Hung-I H Chen, PhD, Carla R Zeballos Torrez, MD, PhD, Xiang Gu, PhD, Matyas Cserhati, PhD, Joel E Michalek, PhD, Glenn A Halff, MD, Yidong Chen, PhD, Siyuan Zheng, PhD, Francisco G Cigarroa, MD, Lu-Zhe Sun, Ph Abstract Background The [...]

JNCI Cancer Spectrum: Neighborhood-level social determinants of health burden among adolescent and young adult cancer patients and impact on overall survival (Aune)

September 3, 2024

Elizabeth R Rodriguez, BS, Tori Tonn, BS, Midhat Jafry, BS, Sairah Ahmed, MD, Branko Cuglievan, MD, J Andrew Livingston, MD, Christopher R Flowers, MD, Gregory J Aune, MD, PhD, Karen H Albritton, MD, Michael E Roth, MD, Qian Xiao, PhD, Michelle A T Hildebrandt, PhD Abstract Background Neighborhood socioeconomic deprivation has been linked to adverse health outcomes, yet it is unclear whether neighborhood-level social determinants of [...]

Nature Communications: DSS1 restrains BRCA2’s engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis (Zhao)

August 20, 2024

Yuxin Huang, Wenjing Li, Tzeh Foo, Jae-Hoon Ji, Bo Wu, Nozomi Tomimatsu, Qingming Fang, Boya Gao, Melissa Long, Jingfei Xu, Rouf Maqbool, Bipasha Mukherjee, Tengyang Ni, Salvador Alejo, Yuan He, Sandeep Burma, Li Lan, Bing Xia & Weixing Zhao Abstract DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR), associates with the helical domain (HD) and OB-fold [...]