RNA Biology: The Paralogues MAGOH and MAGOHB are Oncogenic Factors in High-Grade Gliomas and Safeguard the Splicing of Cell Division and Cell Cycle Genes (Penalva Lab)

June 9, 2023

Rodrigo A. S. Barreiro, Gabriela D. A. Guardia, Fabiana M. Meliso, Xiufen Lei, Wei-Qing Li, Andre Savio, Martin Fellermeyer, Helena B. Conceição, Rafael L. V. Mercuri, Tesha Landry, Mei Qiao, Lorea Blazquez, Jernej Ule, Luiz O.F. Penalva & Pedro A. F. Galante ABSTRACT The exon junction complex (EJC) plays key roles throughout the lifespan of [...]

Journal of Clinical Oncology: The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer (Aune Co-author)

June 5, 2023

Joseph A. Flores-Toro  , PhD1; Subhashini Jagu  , PhD1; Gregory T. Armstrong, MD, MSCE2; David F. Arons, JD3; Gregory J. Aune, MD, PhD4; Stephen J. Chanock  , MD1; Douglas S. Hawkins  , MD5; Allison Heath  , PhD6; Lee J. Helman  , MD7; Katherine A. Janeway  , MD, MMSc8; Jason E. Levine  , MD1; Ellyn Miller, [...]

ELife: Defining function of wild-type and three patient specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma (Ignatius Lab, Houghton Lab, Libich Lab, Chen, Tomlinson)

June 2, 2023

Jiangfei Chen Kunal Baxi Amanda E Lipsitt Nicole Rae Hensch Long Wang Prethish Sreenivas Paulomi Modi Xiang Ru Zhao Antoine Baudin Daniel G Robledo Abhik Bandyopadhyay Aaron Sugalski Anil K Challa Dias Kurmashev Andrea R Gilbert Gail E Tomlinson Peter Houghton Yidong Chen Madeline N Hayes Eleanor Y Chen David S Libich Myron S Ignatius [...]

Cell Reports: EWSR1 Maintains Centromere Identity (Kitagawa & Houghton labs)

May 30, 2023

Risa Kitagawa 1, Yohei Niikura 1 2, Argentina Becker 1 3, Peter J. Houghton 1, Katsumi Kitagawa 1 4 Highlights EWSR1 is required to maintain CENP-A at the centromere in interphase cells EWSR1 binds to CENP-A through the SYGQ2 region, important for phase separation EWSR1 binds to R loops in vitro through its RNA-recognition motif (RRM) EWSR1 protects CENP-A in the centromeric chromatin by binding to centromeric RNAs Summary The centromere is essential [...]

Clinical Cancer Research: Phase II Investigation of TVB-2640 (Denifanstat)with Bevacizumabin Patients with First Relapse High-Grade Astrocytoma (Chen)

May 24, 2023

William Kelly 1, Adolfo Enrique Diaz Duque 1,Joel Michalek 2, Brandon Konkel 3,L aura Caflisch 3, Yidong Chen 2,Sarath Chand Pathuri 1,Vinu Madhusudanannair-Kunnuparampil 4, John Floyd II 5,and Andrew Brenner 1 ABSTRACT Purpose: Glioblastoma represents the most common primary brain tumor. Although antiangiogenics are used in the recurrent setting, they do not prolong survival. Glioblastoma [...]

Biomolecules: Enhancing the Conformational Stability of the cl-Par-4 Tumor Suppressor via Site-Directed Mutagenesis (Libich Lab)

May 17, 2023

Samjhana Pandey Krishna K. Raut Andrea M. Clark  Antoine Baudin  Lamya Djemri  David S. Libich  Komala Ponniah Steven M. Pascal Abstract Intrinsically disordered proteins play important roles in cell signaling, and dysregulation of these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4), an approximately 40-kilodalton proapoptotic tumor suppressor, is a predominantly intrinsically disordered [...]

Cells: The RNA Demethylase ALKBH5 Maintains Endoplasmic Reticulum Homeostasis by Regulating UPR, Autophagy, and Mitochondrial Function (Chen, Sung, & Rao Labs)

May 17, 2023

Panneerdoss Subbarayalu Pooja Yadav Santosh Timilsina Daisy Medina Kunal Baxi Robert Hromas Ratna K. Vadlamudi Yidong Chen Patrick Sung Manjeet K. Rao Abstract Eukaryotic cells maintain cellular fitness by employing well-coordinated and evolutionarily conserved processes that negotiate stress induced by internal or external environments. These processes include the unfolded protein response, autophagy, endoplasmic reticulum-associated degradation [...]

Thrombosis Research: A cohort study on blood coagulation in childhood cancer survivors (Aune)

May 5, 2023

                  Andrew D. Meyer a, Tyler B. Hughes a, Anjana R. Rishmawi a, Patty Heard a, Shafqat Shah b, Gregory J. Aune b c Highlights Anticoagulants decrease thrombotic events in adults receiving cancer therapy. Survivors of childhood cancer have an increased risk of a thromboembolic stroke. Elevated coagulation protein levels are sensitive biomarkers of thrombosis risk. Our study identified that childhood survivors have chronically elevated [...]

Angelina Vaseva, PhD to Receive Department of Defense Neurofibromatosis Research Program New Investigator Award

April 25, 2023

Abstract Neurofibromatosis type 1 (NF1) -associated malignant peripheral nerve sheath tumor is the leading cause of death in patients with NF1 syndrome. It is a highly aggressive soft-tissue sarcoma with very limited therapy options due to resistance to conventional therapies as well as a metastatic propensity. There is an urgent need for novel and more [...]

PLOS GENETICS: Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent (Chen)

April 6, 2023

Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer Abstract Defective ribosome biogenesis (RiBi) underlies a group of clinically diverse human diseases collectively known as ribosomopathies, core manifestations of which include cytopenias and developmental abnormalities that are believed to stem primarily from [...]