Research Paper
European Journal of Cancer: Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: A systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group (Aune)
September 9, 2021
Elvira C.van Dalena Renée L.Muldera EugeneSuhb Matthew J.Ehrhardtc Gregory J.Auned EditBardief Bradley J.Bensong JuttaBergler-Kleinh Ming H.Cheni EvaFreyf UlrikeHennewigj LianeLockwoodk UllaMartinssonl MonicaMuracam Helenavan der Pala ChrisPlummern KatrinScheinemannopq ChristinaSchinderars Daniel A.Mulrooneyc Highlights • Cancer survivors are at risk for premature coronary artery disease (CAD). • Especially survivors treated with radiotherapy exposing the heart. • This guideline provides […]
Cancer Research: SNAI2-mediated repression of BIM protects rhabdomyosarcoma from ionizing radiation (Houghton, Ignatius, & Zheng Labs)
August 31, 2021
Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton and Myron S. Ignatius Abstract Ionizing radiation (IR) and chemotherapy are mainstays of treatment for patients with rhabdomyosarcoma (RMS), yet the molecular mechanisms that underlie the success or failure of radiotherapy remain unclear. The transcriptional repressor SNAI2 was previously identified as a key regulator of IR sensitivity in […]
Frontiers in Immunolgy: Manipulating the NKG2D Receptor-Ligand Axis Using CRISPR: Novel Technologies for Improved Host Immunity (Blancafort)
August 30, 2021
Eric Alves1,2*,Emily McLeish3,Pilar Blancafort1,2,4,Jerome D. Coudert3,5,6†Silvana Gaudieri1,7,8† Abstract The activating immune receptor natural killer group member D (NKG2D) and its cognate ligands represent a fundamental surveillance system of cellular distress, damage, or transformation. Signaling through the NKG2D receptor-ligand axis is critical for early detection of viral infection or oncogenic transformation and the presence of functional […]
Pediatric Blood & Cancer: In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC) (Kurmasheva, Houghton)
August 30, 2021
Raushan T. Kurmasheva, Stephen W. Erickson, Ruolan Han, Beverly A. Teicher, Malcolm A. Smith, Michael Roth, Richard Gorlick, Peter J. Houghton Abstract SP-2577(Seclidemstat), an inhibitor of lysine-specific demthylase KDM1A (LSD1) that is overexpressed in pediatric sarcomas, was evaluated against pediatric sarcoma xenografts. SP-2577 (100 mg/kg/day × 28 days) statistically significantly (p < .05) inhibited the growth of three of eight Ewing sarcoma (EwS), four […]
Biomolecular NMR Assignments: The 1H, 15N and 13C resonance assignments of the C‑terminal domain of Serpine mRNA binding protein 1 (SERBP1), (Libich Lab)
August 30, 2021
Antoine Baudin, Xiaoping Xu & David S. Libich Abstract SERBP1 is a multifunctional mRNA-binding protein that has been shown to play a regulatory role in a number of biological processes such as thrombosis, DNA damage repair, and the cellular response to nutrient deprivation. Additionally, SERBP1 is upregulated in glioblastoma, leukemia as well as liver, prostrate and […]
Science Advances: Predicting and characterizing a cancer dependency map of tumors with deep learning (Aune, Chen, Rao, Houghton & Zheng Labs)
August 24, 2021
Yu-Chiao Chiu1, Siyuan Zheng1,2, Li-Ju Wang1, View ORCID ProfileBrian S. Iskra1, View ORCID ProfileManjeet K. Rao1,3, Peter J. Houghton1,4, View ORCID ProfileYufei Huang5,6,* and View ORCID ProfileYidong Chen1,2,* Abstract Genome-wide loss-of-function screens have revealed genes essential for cancer cell proliferation, called cancer dependencies. It remains challenging to link cancer dependencies to the molecular compositions of cancer […]
BRCA2 Promotes Spontaneous Homologous Recombination In Vivo (Bishop)
August 9, 2021
Adam D. Brown, Scott Greenman, Alison B. Claybon, Alexander J. R. Bishop Simple Summary Inherited mutation of either BRCA1 or BRCA2 is associated with familial breast and ovarian cancer. As a tumor suppressor, BRCA2 functions to maintain genome stability but we do not know the genomic impact of this deficiency on normal tissues in normal contexts, rather than […]
Neuro-Oncololgy Advances: The effects of palbociclib in combination with radiation in preclinical models of aggressive meningioma (Houghton)
August 4, 2021
Craig Horbinski, Guifa Xi, Yufen Wang, Rintaro Hashizume, Mahesh Gopalakrishnan, Joanna J Phillips, Peter Houghton, Charles D James, John A Kalapurakal Abstract Background Meningiomas are the most common tumor arising within the cranium of adults. Despite surgical resection and radiotherapy, many meningiomas invade the brain, and many recur, often repeatedly. To date, no chemotherapy has proven effective against such tumors. Thus, there is […]
MSystems: Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia (Lai Lab)
August 4, 2021
Wurihan Wurihan , Yi Zou, Alec M. Weber, Korri Weldon, Yehong Huang, Xiaofeng Bao, Chengsheng Zhu, Xiang Wu, Yaqun Wang, Zhao Lai, and Huizhou Fan ABSTRACT Chlamydia trachomatis is an obligate intracellular bacterium whose unique developmental cycle consists of an infectious elementary body and a replicative reticulate body. Progression of this developmental cycle requires temporal control of the transcriptome. In addition to the three chlamydial sigma factors (σ66, σ28, and σ54) that recognize promoter sequences of […]
Yogesh Gupta Awarded, 5-year $3.0 million R01 NIH/NIAID Grant to Support His SARS-CoV-2 and RNA Methylation Work.
July 29, 2021
Dr. Yogesh Gupta was awarded a 5-year $3.0 million R01 NIH/NIAID (National Institute of Allergy and Infectious Diseases) grant to support his SARS-CoV-2 and RNA methylation work. ABSTRACT The massive global pandemic with high morbidity and mortality makes Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) one of the deadliest viruses in recent history. It is especially noteworthy for hijacking the normal operations of […]