Stand Up to Cancer: Alexander J. R. Bishop, DPhil to Lead One of Three Trans-Atlantic Teams to Study Hard-to-Treat Childhood Cancers

Alexander J. R. Bishop, DPhil.Published On: October 19, 2020
Shared by Rosanne Fohn

SAN ANTONIO (Oct. 19, 2020) — Although COVID-19 has become the top health and research priority around the world, a child is still diagnosed with cancer every two minutes globally.

To meet this urgent need, the Stand Up To Cancer and Cancer Research UK’s Pediatric Cancer New Discoveries Challenge has awarded grants to three international teams to study aspects of hard-to-treat pediatric cancer.

One of the grants will go to Alexander J. R. Bishop, DPhil, at The University of Texas Health San Antonio and Professor Kevin Hiom at the University of Dundee, Scotland, who will team up to investigate a unique biological hallmark of Ewing sarcoma, a type of cancer that affects bones and the surrounding tissue and has very limited treatment options. The focus of their study involves R-loops. R-loops are present in higher amounts in Ewing sarcoma and are caused by the same genetic alteration that drives this pediatric cancer. The team hopes to create a drug that will impact R-loop accumulation and eliminate these cancer cells.

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Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on childhood cancer by discovering, developing, and disseminating new scientific knowledge. Our mission consists of three key areas — research, clinical, and education.

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