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CANCER RESEARCH: SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation (Houghton, Ignatius, Vaseva, and Zheng labs)

November 24, 2021

Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton and Myron S. Ignatius Abstract Ionizing radiation (IR) and chemotherapy [...]

Communications Biology: LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer (Chen)

November 1, 2021

Mengxing Li, Suryavathi Viswanadhapalli, Bindu Santhamma, Uday P. Pratap, Yiliao Luo, Junhao Liu, Kristin A. Altwegg, Weiwei Tang, Zexuan Liu, Xiaonan Li, Behnam Ebrahimi, Hui Yan, Yi Zou, Swapna Konda, Gangadhara R. Sareddy, Zhenming Xu, Yidong Chen, Manjeet K. Rao, Andrew J. Brenner, Virginia G. Kaklamani, Rajeshwar R. Tekmal, Gulzar Ahmed, Ganesh V. Raj, Klaus [...]

Molecular Cancer Research: GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer (Chen)

October 27, 2021

Marieke Burleson, Janice J. Deng, Tai Qin, Thu Minh Duong, Yuqian Yan, Xiang Gu, Debodipta Das, Acarizia Easley, Michael A. Liss, P. Renee Yew, Roble Bedolla, Addanki Pratap Kumar, Tim Hui-Ming Huang, Yi Zou, Yidong Chen, Chun-Liang Chen, Haojie Huang, Lu-Zhe Sun and Thomas G. Boyer Abstract Although the Sonic hedgehog (SHH) signaling pathway has been implicated in promoting malignant phenotypes of prostate cancer, details on how it is activated and exerts its oncogenic role during prostate cancer development and progression are less clear. Here, we show that GLI3, a key SHH pathway [...]

Free Radical Biology and Medicine: Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer (Bishop Lab)

October 26, 2021

MarinaDelgoboa  Rosângela MayerGonçalvesag  Marco AntônioDelazerib  MarceloFalchettia  AlessandroZandonáb  RaquelNascimento das Nevesa  KarolineAlmeidaa  Adriane CristinaFagundesa  Daniel PensGelainc  João IsidroFracassod  Guilherme Baroni deMacêdod  LeonardoPriorid  NicklasBassanie  Alexander James RoyBishopef  Cassiano MateusForcelinib  José Cláudio FonsecaMoreirac1  AlfeuZanotto-Filhoa1 Highlights • Amid 64 redox genes, TXNRD1 shows association with poor survival in NSCLC. • High TXNRD1 levels predict poor DFS and DMFS in [...]

JoVE: Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins (Libich Lab)

October 13, 2021

Courtney N. Johnson1, David S. Libich1 Abstract Intrinsically disordered proteins and intrinsically disordered regions within proteins make up a large and functionally significant part of the human proteome. The highly flexible nature of these sequences allows them to form weak, long-range, and transient interactions with diverse biomolecular partners. Specific yet low-affinity interactions promote promiscuous binding [...]

Cancer Research: SNAI2-mediated repression of BIM protects rhabdomyosarcoma from ionizing radiation (Houghton, Ignatius, & Zheng Labs)

August 31, 2021

Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton and Myron S. Ignatius Abstract Ionizing radiation (IR) and chemotherapy are mainstays of treatment for patients with rhabdomyosarcoma (RMS), yet the molecular mechanisms that underlie the success or failure of radiotherapy remain unclear. The transcriptional repressor SNAI2 was previously identified as a key regulator of IR sensitivity in […]

Science Advances: Predicting and characterizing a cancer dependency map of tumors with deep learning (Aune, Chen, Rao, Houghton & Zheng Labs)

August 24, 2021

Yu-Chiao Chiu1, Siyuan Zheng1,2, Li-Ju Wang1, View ORCID ProfileBrian S. Iskra1, View ORCID ProfileManjeet K. Rao1,3, Peter J. Houghton1,4, View ORCID ProfileYufei Huang5,6,* and View ORCID ProfileYidong Chen1,2,* Abstract Genome-wide loss-of-function screens have revealed genes essential for cancer cell proliferation, called cancer dependencies. It remains challenging to link cancer dependencies to the molecular compositions of cancer […]

Drs Houghton and Kurmasheva to Receive 5-year, $2.9M NCI Pediatric In Vivo Testing Program (PIVOT) U01 Grant Renewal

August 10, 2021

NCI Pediatric In Vivo Testing Program (U01), renewal for the previous PPTC (Pediatric Preclinical Testing Consortium). Grant period:            July 2021-June 2026. Total dollar amount:  $2,900,000 over 5 years. Abstract Cancer in children is rare with approximately 15,700 new cases diagnosed annually in children 21 years or younger in the U.S. [...]

Henry Miller (Bishop Lab) Receives NIA F31 Fellowship Award

August 6, 2021

Congrats to Henry Miller (Mentor: Alexander Bishop, D. Phil.) on recently being awarded a Ruth L. Kirschstein Predoctoral Individual National Research Service Award ,NIA F31 fellowship! We asked Henry to tell us more about the project he will be leading and how it will affect his future as a researcher. What is the general scope […]

Yogesh Gupta Awarded, 5-year $3.0 million R01 NIH/NIAID Grant to Support His SARS-CoV-2 and RNA Methylation Work.

July 29, 2021

Dr. Yogesh Gupta was awarded a 5-year $3.0 million R01 NIH/NIAID (National Institute of Allergy and Infectious Diseases) grant to support his SARS-CoV-2 and RNA methylation work. ABSTRACT The massive global pandemic with high morbidity and mortality makes Severe Acute Respiratory Syndrome coronavirus-2  (SARS-CoV-2) one of the deadliest viruses in recent history. It is especially noteworthy for hijacking the normal operations of […]