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San Antonio Report: UT Health San Antonio President William Henrich has died

March 14, 2024

Breaking News San Antonio Report: UT Health San Antonio President William Henrich has died (Back row, Middle) Dr. Henrich Originally posted, San Antonio Report 3/14/24 Dr. William L. Henrich, the president of UT Health San Antonio, has died, the school confirmed Thursday. Henrich helmed one of the state’s top health schools since 2009, leading UT [...]

Greehey CCRI part of “CPRIT funding of $16.4 million over six months adds transformative expertise, bolsters cancer research.”

March 8, 2024

Posted initially on UT Health San Antonio Newsroom on March 7, 2024 at 6:44 am. Shared by Steven Lee Contact: Steven Lee, 210-450-3823, lees22@uthscsa.edu Content contributed by Juanita Alvarez-Hernandez SAN ANTONIO, March 7, 2024 – The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has secured approximately $16.4 million in funding from the Cancer Prevention [...]

Angelina Vaseva, PhD to Receive Department of Defense Neurofibromatosis Research Program New Investigator Award

April 25, 2023

Abstract Neurofibromatosis type 1 (NF1) -associated malignant peripheral nerve sheath tumor is the leading cause of death in patients with NF1 syndrome. It is a highly aggressive soft-tissue sarcoma with very limited therapy options due to resistance to conventional therapies as well as a metastatic propensity. There is an urgent need for novel and more [...]

Angelina Vaseva, PhD to Receive NCI Method to Extend Research in Time (MERIT)(R37) Award.

March 2, 2022

Angelina Vaseva, PhDAssistant Professor,Department of Molecular Medicine,Greehey Children’s Cancer Research Institute Congratulations to Dr. Vaseva on being awarded an NCI Method to Extend Research in Time (MERIT)(R37) Award. NCI R37 award provides longer-term grant support to Early Stage Investigators (ESIs) that receive outstanding R01 grant scores. Eligible investigators may obtain up to seven years of [...]

Communications Biology: LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer (Chen)

November 1, 2021

Mengxing Li, Suryavathi Viswanadhapalli, Bindu Santhamma, Uday P. Pratap, Yiliao Luo, Junhao Liu, Kristin A. Altwegg, Weiwei Tang, Zexuan Liu, Xiaonan Li, Behnam Ebrahimi, Hui Yan, Yi Zou, Swapna Konda, Gangadhara R. Sareddy, Zhenming Xu, Yidong Chen, Manjeet K. Rao, Andrew J. Brenner, Virginia G. Kaklamani, Rajeshwar R. Tekmal, Gulzar Ahmed, Ganesh V. Raj, Klaus [...]

Molecular Cancer Research: GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer (Chen)

October 27, 2021

Marieke Burleson, Janice J. Deng, Tai Qin, Thu Minh Duong, Yuqian Yan, Xiang Gu, Debodipta Das, Acarizia Easley, Michael A. Liss, P. Renee Yew, Roble Bedolla, Addanki Pratap Kumar, Tim Hui-Ming Huang, Yi Zou, Yidong Chen, Chun-Liang Chen, Haojie Huang, Lu-Zhe Sun and Thomas G. Boyer Abstract Although the Sonic hedgehog (SHH) signaling pathway has been implicated in promoting malignant phenotypes of prostate cancer, details on how it is activated and exerts its oncogenic role during prostate cancer development and progression are less clear. Here, we show that GLI3, a key SHH pathway [...]

JoVE: Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins (Libich Lab)

October 13, 2021

Courtney N. Johnson1, David S. Libich1 Abstract Intrinsically disordered proteins and intrinsically disordered regions within proteins make up a large and functionally significant part of the human proteome. The highly flexible nature of these sequences allows them to form weak, long-range, and transient interactions with diverse biomolecular partners. Specific yet low-affinity interactions promote promiscuous binding [...]

Yogesh Gupta Awarded, 5-year $3.0 million R01 NIH/NIAID Grant to Support His SARS-CoV-2 and RNA Methylation Work.

July 29, 2021

Dr. Yogesh Gupta was awarded a 5-year $3.0 million R01 NIH/NIAID (National Institute of Allergy and Infectious Diseases) grant to support his SARS-CoV-2 and RNA methylation work. ABSTRACT The massive global pandemic with high morbidity and mortality makes Severe Acute Respiratory Syndrome coronavirus-2  (SARS-CoV-2) one of the deadliest viruses in recent history. It is especially noteworthy for hijacking the normal operations of […]

Nature Communications: Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase (Gupta)

June 29, 2021

Olga Rechkoblit, Robert E. Johnson, Yogesh K. Gupta, Louise Prakash, Satya Prakash & Aneel K. Aggarwal Abstract PrimPol is a human DNA polymerase-primase that localizes to mitochondria and nucleus and bypasses the major oxidative lesion 7,8-dihydro-8-oxoguanine (oxoG) via translesion synthesis, in a mostly error-free manner. We present structures of PrimPol insertion complexes with a DNA template-primer and correct dCTP or erroneous […]