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UT Health SA Newsroom: CPRIT awards $10.9 million to Greehey institute for cancer research
May 20, 2016
The Greehey Children’s Cancer Research Institute at the Health Science Center garnered $10.9 million from the Cancer Prevention & Research Institute of Texas (CPRIT)―a larger amount than any other academic institution in the state. The Health Science Center received 24 percent of the $45.3 million awarded to 13 academic institutions on May 18. The grant was the […]
RNA Biology: High-throughput analyses of hnRNP H1 dissects its multi-functional aspect
April 2, 2016
Authors Philip J Uren, Emad Bahrami-Samani, Patricia Rosa de Araujo, Christine Vogel, Mei Qiao, Suzanne C Burns, Andrew D Smith, Luiz OF Penalva hnRNPs are polyvalent RNA binding proteins that have been implicated in a range of regulatory roles including splicing, mRNA decay, translation, and miRNA metabolism. A variety of genome-wide studies have taken advantage […]
Oncotarget: An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype
October 23, 2015
Ming-Kai Chuang1,*, Yu-Chiao Chiu2,5,*, Wen-Chien Chou1,3, Hsin-An Hou3, Mei-Hsuan Tseng3, Yi-Yi Kuo1,3, Yidong Chen5,6, Eric Y. Chuang2,4, Hwei-Fang Tien3 ABSTRACT Although clinical features, cytogenetics, and mutations are widely used to predict prognosis in patients with acute myeloid leukemia (AML), further refinement of risk stratification is necessary for optimal treatment, especially in cytogenetically normal (CN) patients. […]
San Antonio Report: Greehey Institute Receives $3.7 Million Cancer Grant
September 26, 2014
A cancer diagnosis is difficult news for anyone, and it can be particularly frightening and heart-wrenching for a family with a cancer-stricken child living in a lower-income area without access to adequate health care. The National Cancer Institute has awarded a $3.7 million grant to the Greehey Children’s Cancer Research Institute at the UT Health Science Center to address […]
TPR: $3.7 Million Grant Will Help UTHSCSA Study Children’s Cancer
September 24, 2014
Children’s cancer research in San Antonio is getting a boost from the National Cancer Institute. A new infusion of $3.7 million is dedicated to helping an underserved population in South Texas. South Central Texas is designated is one of 12 sites in the United States with the largest populations of underserved minority children.
St. Baldrick’s: UT Health Science Center Pediatric Cancer Researcher Receives Grant in Groundbreaking Work for Childhood Cancer Survivors
August 13, 2014
UT Health Science Center Pediatric Cancer Researcher Receives Grant in Groundbreaking Work for Childhood Cancer Survivors A pediatric hematologist-oncologist from the University of Texas Health Science Center at San Antonio has been awarded a grant from the St. Baldrick’s Foundation to continue his groundbreaking work into the long-term problems that lifesaving chemotherapy can cause in […]
Hepatology: Astrocyte elevated gene‐1 and c‐Myc cooperate to promote hepatocarcinogenesis in mice
July 28, 2014
Jyoti Srivastava Ayesha Siddiq Rachel Gredler Xue‐Ning Shen Devaraja Rajasekaran Chadia L. Robertson Mark A. Subler Jolene J. Windle Catherine I. Dumur Nitai D. Mukhopadhyay Dawn Garcia Zhao Lai Yidong Chen Uthra Balaji Paul B. Fisher Devanand Sarkar Abstract Astrocyte elevated gene‐1 (AEG‐1) and c‐Myc are overexpressed in human hepatocellular carcinoma (HCC) functioning as oncogenes. AEG‐1 is transcriptionally regulated by c‐Myc, and AEG‐1 itself induces c‐Myc by activating the […]
PNAS: Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling
June 17, 2014
Bhuvanesh Dave, Sergio Granados-Principal, Rui Zhu, Stephen Benz, Shahrooz Rabizadeh, Patrick Soon-Shiong, Ke-Da Yu, Zhimin Shao, Xiaoxian Li, Michael Gilcrease, Zhao Lai, Yidong Chen, Tim H.-M. Huang, Haifa Shen, Xuewu Liu, Mauro Ferrari, Ming Zhan, Stephen T. C. Wong, Muthiah Kumaraswami, Vivek Mittal, Xi Chen, Steven S. Gross, and Jenny C. Chang Abstract We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. Selective shRNA knockdown identified ribosomal protein L39 (RPL39) […]
Molecular Ecology Resources: Genomics of Compositae crops: reference transcriptome assemblies and evidence of hybridization with wild relatives
January 1, 2014
Kathryn A Hodgins 1, Zhao Lai, Luiz O Oliveira, David W Still, Moira Scascitelli, Michael S Barker, Nolan C Kane, Hannes Dempewolf, Alex Kozik, Richard V Kesseli, John M Burke, Richard W Michelmore, Loren H Rieseberg Abstract Although the Compositae harbors only two major food crops, sunflower, and lettuce, many other species in this family are utilized by humans and have experienced various levels of domestication. Here, we […]
BMC Systems Biology: BRCA-Monet: a breast cancer specific drug treatment mode-of-action network for treatment effective prediction using large scale microarray database
December 9, 2013
Chifeng Ma, Hung-I Harry Chen, Mario Flores, Yufei Huang & Yidong Chen Abstract Background Connectivity map (cMap) is a recently developed dataset and algorithm for uncovering and understanding the treatment effect of small molecules on different cancer cell lines. It is widely used but there are still remaining challenges for accurate predictions. Method Here, we propose BRCA-MoNet, a network of […]