Category
February 22, 2019
The Cancer Prevention and Research Institute of Texas has awarded 54 new academic research, prevention and product development grants totaling nearly $96 million. San Antonio’s cut is $3 million. All three Alamo City grants will support research at UT Health San Antonio. They include a pair of $900,000 awards and one for $1.2 million. Dr. Yuzuru […]
February 22, 2019
Ewing sarcoma research Yuzuru Shiio, MD, PhD, of the Greehey Children’s Cancer Research Institute at UT Health San Antonio, was awarded $1.2 million to further studies of Ewing sarcoma, a pediatric bone and soft tissue cancer. The median age of Ewing sarcoma patients is 15 years, and more than half of patients are adolescents. Dr. […]
October 31, 2018
Nourhan Abdelfattah, Subapriya Rajamanickam, Subbarayalu Panneerdoss, Santosh Timilsina, Pooja Yadav, Benjamin C. Onyeagucha, Michael Garcia, Ratna Vadlamudi, Yidong Chen, Andrew Brenner, Peter Houghton & Manjeet K. Rao Abstract Despite improvements in overall survival, only a modest percentage of patients survive high-risk medulloblastoma. The devastating side effects of radiation and chemotherapy substantially reduce the quality of life for surviving patients. Here, using genomic screens, we identified miR-584-5p as a […]
September 7, 2018
Myron S Ignatius # 1 2 3 4, Madeline N Hayes # 1 2 3, Finola E Moore 1 2 3, Qin Tang 1 2 3, Sara P Garcia 1, Patrick R Blackburn 5, Kunal Baxi 4, Long Wang 4, Alexander Jin 1, Ashwin Ramakrishnan 1, Sophia Reeder 1, Yidong Chen 4, Gunnlaugur Petur Nielsen 1 2, Eleanor Y Chen 6, Robert P Hasserjian 1 2, Franck Tirode 7, Stephen C Ekker 8, David M Langenau 1 2 3 Abstract The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germline inactivation are predisposed to developing cancer. Here, we generated tp53 deleted […]
September 7, 2018
Myron S Ignatius, Madeline N Hayes, Finola E Moore, Qin Tang, Sara P Garcia, Patrick R Blackburn, Kunal Baxi, Long Wang, Alexander Jin, Ashwin Ramakrishnan, Sophia Reeder, Yidong Chen, Gunnlaugur Petur Nielsen, Eleanor Y Chen, Robert P Hasserjian, Franck Tirode, Stephen C Ekker, David M Langenau Abstract The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germline inactivation are predisposed to developing cancer. Here, we generated tp53 deleted […]
April 23, 2018
Ana C deCarvalho 1, Hoon Kim 2, Laila M Poisson 3, Mary E Winn 4, Claudius Mueller 5, David Cherba 4, Julie Koeman 6, Sahil Seth 7, Alexei Protopopov 7, Michelle Felicella 8, Siyuan Zheng 9, Asha Multani 10, Yongying Jiang 7, Jianhua Zhang 7, Do-Hyun Nam 11 12 13, Emanuel F Petricoin 5, Lynda Chin 7 9, Tom Mikkelsen 14 15, Roel G W Verhaak 16 Abstract To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft […]
April 6, 2018
“Greehey Children’s Cancer Research Institute gets $10.9 million grant” Aune Lab Houghton Lab
March 8, 2018
Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]
March 7, 2018
A mutant oncogene in Ewing traps BRCA1 and prevents it from repairing genetic damage. Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism […]