Nature Genetics: Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
April 23, 2018
Ana C deCarvalho 1, Hoon Kim 2, Laila M Poisson 3, Mary E Winn 4, Claudius Mueller 5, David Cherba 4, Julie Koeman 6, Sahil Seth 7, Alexei Protopopov 7, Michelle Felicella 8, Siyuan Zheng 9, Asha Multani 10, Yongying Jiang 7, Jianhua Zhang 7, Do-Hyun Nam 11 12 13, Emanuel F Petricoin 5, Lynda Chin 7 9, Tom Mikkelsen 14 15, Roel G W Verhaak 16 Abstract To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft […]
KSAT: “Record grant helps survivor now working at cancer institute that saved him” (video)
April 6, 2018
“Greehey Children’s Cancer Research Institute gets $10.9 million grant” Aune Lab Houghton Lab
Technology Networks: Link Discovered Between BRCA1 Protein and Aggressive Pediatric Cancer
March 8, 2018
Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]
UT Health SA Newsroom: Greehey Institute team finds link between BRCA1 and Ewing sarcoma
March 7, 2018
A mutant oncogene in Ewing traps BRCA1 and prevents it from repairing genetic damage. Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism […]
EurekAlert: Greehey Institute team finds link between BRCA1 and Ewing sarcoma
March 7, 2018
Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]
Life Extension Advocacy Foundation: Greehey Institute team finds link between BRCA1 and Ewing sarcoma
March 7, 2018
Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]
Nature: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
March 7, 2018
Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A. Lawrence, Elicia Goodale, Amanda Balboni Iniguez, Xavier Bernard, V. Pragathi Masamsetti, Sydney Roston, Elizabeth R. Lawlor, Jeffrey A. Toretsky, Kimberly Stegmaier, Stephen L. Lessnick, Yidong Chen & Alexander J. R. Bishop Abstract Ewing sarcoma is an aggressive pediatric cancer of the bone and soft tissue. It results from a chromosomal translocation, predominantly t(11;22)(q24:q12), that fuses the N-terminal transactivation domain of […]
Scientific Reports: Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity
March 6, 2018
Bruna RS Correa, Joanna Hu, Luiz OF Penalva, Richard Schlegel, David L Rimm, Pedro AF Galante, Seema Agarwal Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug target identification and drug discovery efforts. For any model to be clinically relevant, it needs […]
Cell Death & Disease: miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer
February 7, 2018
Xiaojie Yu, Yiqiang Zhang, David Cavazos, Xiuye Ma, Zhenze Zhao, Liqin Du & Alexander Pertsemlidis Abstract miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). However, the mechanisms by which miR-195 represses the tumorigenesis of NSCLC cells are not fully understood. We performed a high-throughput […]