Clinical Cancer Research: Gene Expression Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma

February 1, 2007

Hu-Liang Jia, Qing-Hai Ye, Lun-Xiu Qin, Anuradha Budhu, Marshonna Forgues, Yidong Chen, Yin-Kun Liu, Hui-Chuan Sun, Lu Wang, Hong-Zhou Lu, Fang Shen, Zhao-You Tang and Xin Wei Wang Abstract Purpose: Hepatocellular carcinoma (HCC), common cancer worldwide, has a dismal outcome partly due to the poor identification of early-stage HCC. Currently, one-third of HCC patients present with low serum α-fetoprotein (AFP) levels, the only clinically available diagnostic marker for HCC. The aim of this study was to identify new diagnostic molecular markers […]

Nature Methods: Sensitive and specific method for detecting G protein–coupled receptor mRNAs

November 19, 2006

Arne Hansen, Yidong Chen, Jason M Inman, Quang N Phan, Zhi-Qing Qi, Charlie C Xiang, Miklos Palkovits, Natasha Cherman, Sergei A Kuznetsov, Pamela G Robey, Eva Mezey & Michael J Brownstein Abstract G protein-coupled receptors (GPCRs) mediate the effects of extracellular signaling molecules in all the body’s cells. These receptors are encoded by scarce mRNAs; therefore, detecting their transcripts with conventional microarrays is difficult. We present a […]

Cancer Cell: Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment

August 1, 2006

Author links open overlay panelAnuradha Budhu1, Marshonna Forgues1, Qing-HaiYe2, Hu-Liang Jia12, Ping He3, Krista A.Zanetti4, Udai S.Kammula5, Yidong Chen6, Lun-XiuQin2, Zhao-YouTang2, Xin WeiWang1 Summary Hepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to metastases or postsurgical recurrence. We postulate that metastases are influenced by liver microenvironment. Here, we show that a unique inflammation/immune response-related signature is […]

Oncogene: Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells

November 13, 2005

M-H Tsai, X Chen, G V R Chandramouli, Y Chen, H Yan, S Zhao, P Keng, H L Liber, C N Coleman, J B Mitchell & E Y Chuang Abstract The p53 protein has been implicated in multiple cellular responses related to DNA damage. Alterations in any of these cellular responses could be related to increased genomic instability. Our previous study has shown that mutations in […]