Journal of Exposure Science & Environmental Epidemiology: Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children’s Oncology Group

March 8, 2017

Amanda E Janitz, Gurumurthy Ramachandran, Gail E Tomlinson, Mark Krailo, Michaela Richardson & Logan Spector Abstract Little is known about the etiology of hepatoblastoma. We aimed to confirm the results of a previous study evaluating the association between parental occupational exposures and hepatoblastoma. In our case-control study, we identified cases (n=383) from the Children’s Oncology Group […]

Aging: Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential

November 15, 2016

Qiaoxiang Dong1,2 , Hui Gao1,2 , Yuanshuo Shi1,3 , Fuchuang Zhang1,3 , Xiang Gu1 , Anqi Wu3 , Danhan Wang3 , Yuanhong Chen3 , Abhik Bandyopadhyay1 , I-Tien Yeh4 , Benjamin J. Daniel5 , Yidong Chen6,8 , Yi Zou8 , Vivienne L. Rebel1,7,8 , Christi A. Walter1 , Jianxin Lu2 , Changjiang Huang3 , Lu-Zhe Sun1,7 Abstract Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age are unknown. We compared mammary epithelial cells isolated from young and old mammary glands of […]

Scientific Reports: Differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers

November 12, 2016

Tzu-Hung Hsiao, Yu-Chiao Chiu, Pei-Yin Hsu, Tzu-Pin Lu, Liang-Chuan Lai, Mong-Hsun Tsai, Tim H.-M. Huang, Eric Y. Chuang Yidong Chen Abstract Several mutual information (MI)-based algorithms have been developed to identify dynamic gene-gene and function-function interactions governed by key modulators (genes, proteins, etc.). Due to intensive computation, however, these methods rely heavily on prior knowledge […]

Hyundai Hope on Wheels Awards $250,000 Research Grant to Ut Health Science Center San Antonio in Honor of National Childhood Cancer Awareness Month

September 12, 2016

San Antonio, TX – September 12 – Hyundai Hope On Wheels® (HHOW) and San Antonio-area Hyundai dealers will present UT Health Science Center San Antonio with a $250,000 Scholar Grant to be used to improve care and increase treatment options for kids with cancer. UT Health Science Center San Antonio was one of 24 recipients across the […]

BMC Genomics: Detection of high variability in gene expression from single-cell RNA-seq profiling

August 22, 2016

Hung-I Harry Chen, Yufang Jin, Yufei Huang & Yidong Chen Abstract Background The advancement of the next-generation sequencing technology enables mapping gene expression at the single-cell level, capable of tracking cell heterogeneity and determination of cell subpopulations using single-cell RNA sequencing (scRNA-seq). Unlike the objectives of conventional RNA-seq where differential expression analysis is the integral component, the most important […]

BMC Genomics: CrossLink: a novel method for cross-condition classification of cancer subtypes

August 22, 2016

Chifeng Ma, Konduru S. Sastry, Mario Flore, Salah Gehani, Issam Al-Bozom, Yusheng Feng, Erchin Serpedin, Lotfi Chouchane, Yidong Chen & Yufei Huang Abstract Background We considered the prediction of cancer classes (e.g. subtypes) using patient gene expression profiles that contain both systematic and condition-specific biases when compared with the training reference dataset. The conventional normalization-based approaches cannot guarantee that the gene signatures in the reference […]

SA Business Journal: Cancer money to boost local pediatric research

July 3, 2016

The Cancer Prevention & Research Institute of Texas has awarded nearly $11 million to the University of Texas Health Science Center at San Antonio in its latest funding round. That award includes $5 million to help establish the Texas Pediatric Patient-Derived Xenograft Facility. Peter Houghton, director of the Greehey Children’s Cancer Research Institute at the […]

American Journal of Botany: Most Compositae (Asteraceae) are descendants of a paleohexaploid and all share a paleotetraploid ancestor with the Calyceraceae

July 1, 2016

Michael S Barker 1, Zheng Li 2, Thomas I Kidder 2, Chris R Reardon 2, Zhao Lai 3, Luiz O Oliveira 4, Moira Scascitelli 5, Loren H Rieseberg 6 Abstract Premise of the study: Like many other flowering plants, members of the Compositae (Asteraceae) have a polyploid ancestry. Previous analyses found evidence for an ancient duplication or possibly triplication in the early evolutionary history of the family. We sought to better […]

SA Business Journal: Cancer money to boost local pediatric research

June 3, 2016

The Cancer Prevention & Research Institute of Texas has awarded nearly $11 million to the University of Texas Health Science Center at San Antonio in its latest funding round. That award includes $5 million to help establish the Texas Pediatric Patient-Derived Xenograft Facility. Peter Houghton, director of the Greehey Children’s Cancer Research Institute at the […]