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Nature: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
March 7, 2018
Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A. Lawrence, Elicia Goodale, Amanda Balboni Iniguez, Xavier Bernard, V. Pragathi Masamsetti, Sydney Roston, Elizabeth R. Lawlor, Jeffrey A. Toretsky, Kimberly Stegmaier, Stephen L. Lessnick, Yidong Chen & Alexander J. R. Bishop Abstract Ewing sarcoma is an aggressive pediatric cancer of the bone and soft tissue. It results from a chromosomal translocation, predominantly t(11;22)(q24:q12), that fuses the N-terminal transactivation domain of […]
Scientific Reports: Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity
March 6, 2018
Bruna RS Correa, Joanna Hu, Luiz OF Penalva, Richard Schlegel, David L Rimm, Pedro AF Galante, Seema Agarwal Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug target identification and drug discovery efforts. For any model to be clinically relevant, it needs […]
Cell Death & Disease: miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer
February 7, 2018
Xiaojie Yu, Yiqiang Zhang, David Cavazos, Xiuye Ma, Zhenze Zhao, Liqin Du & Alexander Pertsemlidis Abstract miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). However, the mechanisms by which miR-195 represses the tumorigenesis of NSCLC cells are not fully understood. We performed a high-throughput […]
Childhood Obesity: Characterization of the Stool Microbiome in Hispanic Preschool Children by Weight Status and Time
February 1, 2018
Emily B Hollister 1 2, Byron A Foster 3, Mahmoud Dahdouli 1 2, Jesica Ramirez 4, Zhao Lai 5 Abstract Background: Variations in gut microbiota composition and diversity have been associated with childhood adiposity, although most studies describing this have been cross-sectional in nature. Our objective was to evaluate associations between body weight and the gut microbiota over time in obese preschool-age children. Methods: Obese, preschool-age, Hispanic children […]
Nature Communications: Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
September 19, 2017
Subbarayalu Panneerdoss, Suryavathi Viswanadhapalli, Nourhan Abdelfattah, Benjamin C. Onyeagucha, Santosh Timilsina, Tabrez A. Mohammad, Yidong Chen, Michael Drake, Kristiina Vuori, T. Rajendra Kumar & Manjeet K. Rao Abstract Phagocytic clearance of apoptotic germ cells by Sertoli cells is vital for germ cell development and differentiation. Here, using a tissue-specific miRNA transgenic mouse model, we show that interaction between miR-471-5p and autophagy member proteins regulates the clearance of […]
Scientific Reports: A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling
August 22, 2017
Jing Lin, Roza Zandi, Ruping Shao, Jian Gu, Yuanqin Ye, Jing Wang, Yang Zhao, Alexander Pertsemlidis, Ignacio I. Wistuba, Xifeng Wu, Jack A. Roth & Lin Ji Abstract Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study, we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4 gene linked with decreased risk of […]
CPRIT Grant: Recruitment of First-Time, Tenure-Track Faculty Members
August 16, 2017
“Big Data” is a driving force in cancer research today. Sifting through the data from thousands of cancer genomes will help researchers understand what drives cancer, and help them make predictions about therapies that will be most beneficial to individual patients. To help make sense of these data, and in particular, to apply the findings […]
Nature: The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution
May 22, 2017
Hélène Badouin, Jérôme Gouzy, Christopher J. Grassa, Florent Murat, S. Evan Staton, Ludovic Cottret, Christine Lelandais-Brière, Gregory L. Owens, Sébastien Carrère, Baptiste Mayjonade, Ludovic Legrand, Navdeep Gill, Nolan C. Kane, John E. Bowers, Sariel Hubner, Arnaud Bellec, Aurélie érard, Hélène Bergès, Nicolas Blanchet, Marie-Claude Boniface, Dominique Brunel, Olivier Catrice, Nadia Chaidir, Clotilde Claudel, Cécile Donnadieu, Thomas Faraut, Ghislain Fievet, Nicolas Helmstetter, Matthew King, Steven J. Knapp, Zhao Lai, Marie-Christine Le Paslier, Yannick Lippi, Lolita Lorenzon, Jennifer R. Mandel, Gwenola Marage, Gwenaëlle Marchand, Elodie Marquand, Emmanuelle Bret-Mestries, Evan Morien, Savithri Nambeesan, Thuy Nguyen, Prune Pegot-Espagnet, Nicolas Pouilly, Frances Raftis, Erika Sallet, Thomas […]
Journal of Exposure Science & Environmental Epidemiology: Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children’s Oncology Group
March 8, 2017
Amanda E Janitz, Gurumurthy Ramachandran, Gail E Tomlinson, Mark Krailo, Michaela Richardson & Logan Spector Abstract Little is known about the etiology of hepatoblastoma. We aimed to confirm the results of a previous study evaluating the association between parental occupational exposures and hepatoblastoma. In our case-control study, we identified cases (n=383) from the Children’s Oncology Group […]
Aging: Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential
November 15, 2016
Qiaoxiang Dong1,2 , Hui Gao1,2 , Yuanshuo Shi1,3 , Fuchuang Zhang1,3 , Xiang Gu1 , Anqi Wu3 , Danhan Wang3 , Yuanhong Chen3 , Abhik Bandyopadhyay1 , I-Tien Yeh4 , Benjamin J. Daniel5 , Yidong Chen6,8 , Yi Zou8 , Vivienne L. Rebel1,7,8 , Christi A. Walter1 , Jianxin Lu2 , Changjiang Huang3 , Lu-Zhe Sun1,7 Abstract Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age are unknown. We compared mammary epithelial cells isolated from young and old mammary glands of […]