Greehey Children's Cancer Research Institute
Category
September 24, 2014
Children’s cancer research in San Antonio is getting a boost from the National Cancer Institute. A new infusion of $3.7 million is dedicated to helping an underserved population in South Texas. South Central Texas is designated is one of 12 sites in the United States with the largest populations of underserved minority children.
August 13, 2014
UT Health Science Center Pediatric Cancer Researcher Receives Grant in Groundbreaking Work for Childhood Cancer Survivors A pediatric hematologist-oncologist from the University of Texas Health Science Center at San Antonio has been awarded a grant from the St. Baldrick’s Foundation to continue his groundbreaking work into the long-term problems that lifesaving chemotherapy can cause in […]
July 28, 2014
Jyoti Srivastava Ayesha Siddiq Rachel Gredler Xue‐Ning Shen Devaraja Rajasekaran Chadia L. Robertson Mark A. Subler Jolene J. Windle Catherine I. Dumur Nitai D. Mukhopadhyay Dawn Garcia Zhao Lai Yidong Chen Uthra Balaji Paul B. Fisher Devanand Sarkar Abstract Astrocyte elevated gene‐1 (AEG‐1) and c‐Myc are overexpressed in human hepatocellular carcinoma (HCC) functioning as oncogenes. AEG‐1 is transcriptionally regulated by c‐Myc, and AEG‐1 itself induces c‐Myc by activating the […]
June 17, 2014
Bhuvanesh Dave, Sergio Granados-Principal, Rui Zhu, Stephen Benz, Shahrooz Rabizadeh, Patrick Soon-Shiong, Ke-Da Yu, Zhimin Shao, Xiaoxian Li, Michael Gilcrease, Zhao Lai, Yidong Chen, Tim H.-M. Huang, Haifa Shen, Xuewu Liu, Mauro Ferrari, Ming Zhan, Stephen T. C. Wong, Muthiah Kumaraswami, Vivek Mittal, Xi Chen, Steven S. Gross, and Jenny C. Chang Abstract We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. Selective shRNA knockdown identified ribosomal protein L39 (RPL39) […]
January 1, 2014
Kathryn A Hodgins 1, Zhao Lai, Luiz O Oliveira, David W Still, Moira Scascitelli, Michael S Barker, Nolan C Kane, Hannes Dempewolf, Alex Kozik, Richard V Kesseli, John M Burke, Richard W Michelmore, Loren H Rieseberg Abstract Although the Compositae harbors only two major food crops, sunflower, and lettuce, many other species in this family are utilized by humans and have experienced various levels of domestication. Here, we […]
December 9, 2013
Chifeng Ma, Hung-I Harry Chen, Mario Flores, Yufei Huang & Yidong Chen Abstract Background Connectivity map (cMap) is a recently developed dataset and algorithm for uncovering and understanding the treatment effect of small molecules on different cancer cell lines. It is widely used but there are still remaining challenges for accurate predictions. Method Here, we propose BRCA-MoNet, a network of […]
September 16, 2013
L Du, Z Zhao, X Ma, T-H Hsiao, Y Chen, E Young, M Suraokar, I Wistuba, J D Minna & A Pertsemlidis Abstract The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully […]
June 7, 2013
Thomas G. Andrews, M.Sc.,* Merry L. Lindsey, PhD,† Richard A. Lange, MD, M.B.A,‡ and Gregory J. Aune, MD, PhD§ Echocardiography is a robust tool for assessing cardiac function in both humans and laboratory animals. Conventional echocardiographic measurements, including chamber dimensions, wall thickness, and ejection fraction are routinely obtained to assess cardiac function in mice. Recently, […]
February 1, 2013
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen Abstract Extracting maximal information from gene signature sets (GSSs) via microarray-based transcriptional profiling involves assigning function to up and down-regulated genes. Here we present a novel sample scoring method called Signature-score (S-score) which can be used to […]