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Bioinformatics: A probe-density-based analysis method for array CGH data: simulation, normalization and centralization
October 1, 2008
Hung-I Harry Chen, Fang-Han Hsu, Yuan Jiang, Mong-Hsun Tsai, Pan-Chyr Yang, Paul S. Meltzer, Eric Y. Chuang, Yidong Chen Abstract Motivation: Genomic instability is one of the fundamental factors in tumorigenesis and tumor progression. Many studies have shown that copy-number abnormalities at the DNA level are important in the pathogenesis of cancer. Array comparative genomic hybridization (aCGH), developed based on expression microarray technology, […]
Modern Pathology: A subset of cranial fasciitis is associated with dysregulation of the Wnt/beta-catenin pathway
June 27, 2008
Dinesh Rakheja 1, Jacqulin C Cunningham, Midori Mitui, Ashish S Patel, Gail E Tomlinson, Arthur G Weinberg Abstract Cranial fasciitis, an unusual fibroproliferative lesion that occurs in the scalp of infants, is considered a posttraumatic reactive process similar to nodular fasciitis. Its pathobiology has not been investigated. Over the last 15 years, we diagnosed cranial fasciitis in six children; in one […]
American Journal of Human Genetics: Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
April 1, 2008
Antonis C Antoniou 1, Amanda B Spurdle, Olga M Sinilnikova, Sue Healey, Karen A Pooley, Rita K Schmutzler, Beatrix Versmold, Christoph Engel, Alfons Meindl, Norbert Arnold, Wera Hofmann, Christian Sutter, Dieter Niederacher, Helmut Deissler, Trinidad Caldes, Kati Kämpjärvi, Heli Nevanlinna, Jacques Simard, Jonathan Beesley, Xiaoqing Chen, Kathleen Cuningham Consortium for Research into Familial Breast Cancer; Susan L Neuhausen, Timothy R Rebbeck, Theresa Wagner, Henry T Lynch, Claudine Isaacs, Jeffrey Weitzel, Patricia A Ganz, Mary B Daly, Gail Tomlinson, Olufunmilayo I Olopade, Joanne L Blum, Fergus J Couch, Paolo Peterlongo, Siranoush […]
Cancer Research: EpCAM and α-Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma
March 1, 2008
Taro Yamashita, Marshonna Forgues, Wei Wang, Jin Woo Kim, Qinghai Ye, Huliang Jia, Anuradha Budhu, Krista A. Zanetti, Yidong Chen, Lun-Xiu Qin, Zhao-You Tang, and Xin Wei Wang Abstract The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers have hampered patient prognosis and treatment stratification. Recently, we have identified that a hepatic stem cell marker, epithelial cell adhesion molecule (EpCAM), may serve as an early biomarker of HCC because its expression is highly elevated in […]
Clinical Cancer Research: Gene Expression Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma
February 1, 2007
Hu-Liang Jia, Qing-Hai Ye, Lun-Xiu Qin, Anuradha Budhu, Marshonna Forgues, Yidong Chen, Yin-Kun Liu, Hui-Chuan Sun, Lu Wang, Hong-Zhou Lu, Fang Shen, Zhao-You Tang and Xin Wei Wang Abstract Purpose: Hepatocellular carcinoma (HCC), common cancer worldwide, has a dismal outcome partly due to the poor identification of early-stage HCC. Currently, one-third of HCC patients present with low serum α-fetoprotein (AFP) levels, the only clinically available diagnostic marker for HCC. The aim of this study was to identify new diagnostic molecular markers […]
Nature Methods: Sensitive and specific method for detecting G protein–coupled receptor mRNAs
November 19, 2006
Arne Hansen, Yidong Chen, Jason M Inman, Quang N Phan, Zhi-Qing Qi, Charlie C Xiang, Miklos Palkovits, Natasha Cherman, Sergei A Kuznetsov, Pamela G Robey, Eva Mezey & Michael J Brownstein Abstract G protein-coupled receptors (GPCRs) mediate the effects of extracellular signaling molecules in all the body’s cells. These receptors are encoded by scarce mRNAs; therefore, detecting their transcripts with conventional microarrays is difficult. We present a […]
Cancer Cell: Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
August 1, 2006
Author links open overlay panelAnuradha Budhu1, Marshonna Forgues1, Qing-HaiYe2, Hu-Liang Jia12, Ping He3, Krista A.Zanetti4, Udai S.Kammula5, Yidong Chen6, Lun-XiuQin2, Zhao-YouTang2, Xin WeiWang1 Summary Hepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to metastases or postsurgical recurrence. We postulate that metastases are influenced by liver microenvironment. Here, we show that a unique inflammation/immune response-related signature is […]
Oncogene: Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells
November 13, 2005
M-H Tsai, X Chen, G V R Chandramouli, Y Chen, H Yan, S Zhao, P Keng, H L Liber, C N Coleman, J B Mitchell & E Y Chuang Abstract The p53 protein has been implicated in multiple cellular responses related to DNA damage. Alterations in any of these cellular responses could be related to increased genomic instability. Our previous study has shown that mutations in […]