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Human Mutation: Clinical spectrum of individuals with pathogenic NF1 missense variants affecting p.Met1149, p.Arg1276, and p.Lys1423: genotype-phenotype study in neurofibromatosis type 1
October 8, 2019
Magdalena Koczkowska 1, Tom Callens 1, Yunjia Chen 1, Alicia Gomes 1, Alesha D Hicks 1, Angela Sharp 1, Eric Johns 1, Kim Armfield Uhas 2, Linlea Armstrong 3, Katherine Armstrong Bosanko 4, Dusica Babovic-Vuksanovic 5, Laura Baker 6, Donald G Basel 7, Mario Bengala 8, James T Bennett 9, Chelsea Chambers 10, Lola K Clarkson 11, Maurizio Clementi 12, Fanny M Cortés 13, Mitch Cunningham 14, M Daniela D’Agostino 15, Martin B Delatycki 16, Maria C Digilio 17, Laura Dosa 18, Silvia Esposito 19, Stephanie Fox 15, Mary-Louise Freckmann 20, Christine Fauth 21, Teresa Giugliano 22, Sandra Giustini 23, Allison Goetsch 24, Yael Goldberg 25, Robert S Greenwood 26, Cristin Griffis 7, Karen W Gripp 6, Punita Gupta 27, Eric Haan 28, Rachel K Hachen 29, Tamara L Haygarth 30, Concepción Hernández-Chico 31, Katelyn […]
Review article “Challenges and Opportunities for Childhood Cancer Drug Development” co-authored by Drs Kurmasheva and Houghton
October 3, 2019
The review article “Challenges and Opportunities for Childhood Cancer Drug Development” co-authored by Raushan Kurmasheva, PhD and Peter Houghton, PhD has just been published.
Pharmacology Reviews: Challenges and Opportunities for Childhood Cancer Drug Development
October 1, 2019
Peter J Houghton 1, Raushan T Kurmasheva 2 Abstract Cancer in children is rare with approximately 15,700 new cases diagnosed in the United States annually. Through the use of multimodality therapy (surgery, radiation therapy, and aggressive chemotherapy), 70% of patients will be “cured” of their disease, and 5-year event-free survival exceeds 80%. However, for patients surviving their malignancy, […]
Cancer Research: Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma
October 1, 2019
Xiaolong Li 1, Emmanuel Martinez-Ledesma 1 2, Chen Zhang 1, Feng Gao 1, Siyuan Zheng 1, Jie Ding 1, Shaofang Wu 1, Nghi Nguyen 3, Stephan C Clifford 3, Patrick Y Wen 4, Keith L Ligon 4, W K Alfred Yung 1, Dimpy Koul 5 Abstract PI3K-targeting therapy represents one of the most sought-after therapies for glioblastoma (GBM). Several small-molecule inhibitors have been evaluated in clinical trials, however, the emergence of resistance limits treatment potential. Here, we generated a patient-derived glioma […]
WEBINAR: Childhood Cancer Survivorship, Transitioning to Adulthood (Aune Lab)
September 27, 2019
REPOST from September 25th webinar originally broadcasted, September 25th, 2019 Childhood cancer advocates, families, researchers, and survivors are invited to join us for this Childhood Cancer Awareness Month event. We’ll have a robust discussion about the challenges facing childhood cancer survivors as they transition out of pediatric care and into young adulthood. SPEAKERS: Gregory Aune, […]
Molecular Therapy – Oncolytics: The miR-195 Axis Regulates Chemoresistance through TUBB and Lung Cancer Progression through BIRC5
September 27, 2019
Author links open overlay panelXiaojie Yu126, Yiqiang Zhang1, Binggen Wu13, Jonathan M.Kurie4, Alexander Pertsemlidis125 Chemoresistance and metastasis are the major reasons for non-small cell lung cancer (NSCLC) treatment failure and patient deaths. We and others have shown that miR-195 regulates the sensitivity of NSCLC to microtubule-targeting agents (MTAs) in vitro and in vivo and that miR-195 represses the migration and invasion […]
KENS5: UT Health working to fight children’s cancer with Hyundai Hope on Wheels grant (Houghton, Aune, Ignatius mention)
September 24, 2019
UT Health working to fight children’s cancer with Hyundai Hope on Wheels grant To help in the fight against pediatric cancer, Hyundai Hope on Wheels presented two grants totaling $500,000 to UT Health San Antonio. SAN ANTONIO — UT Health San Antonio is fighting children’s cancer in a partnership with Hyundai Hope on Wheels. To […]
BioSpace: Hyundai Hope On Wheels Presents UT Health San Antonio With Hyundai Young Investigator And Scholar Hope Grant Totaling A Combined $500,000 To Support Pediatric Cancer Research (Aune & Ignatius Labs)
September 23, 2019
Hyundai Hope On Wheels® (HHOW), a 501(c)(3) non-profit organization supported by Hyundai and its U.S. dealers, announces $500,000 Hyundai Young Investigator and Scholar Hope Grant to UT Health San Antonio to continue its long-standing fight against pediatric cancer. HHOW has committed $13.2 million to support 52 new doctor-researchers in their research for better treatment options and to improve care for children diagnosed […]
Developmental Cell: CENP-A Ubiquitylation Is Indispensable to Cell Viability
September 23, 2019
Summary CENP-A is a centromere-specific histone H3 variant that epigenetically determines centromere identity, but how CENP-A is deposited at the centromere remains obscure. We previously reported that CENP-A K124 ubiquitylation, mediated by the CUL4A-RBX1-COPS8 complex, is essential for CENP-A deposition at the centromere. However, a recent report stated that CENP-A K124R mutants show no defects […]