UT Health SA Newsroom: UT Health San Antonio physician-researcher contributes to international screening guidelines for rare pediatric cancers

August 2, 2018

SAN ANTONIO (Aug. 2, 2017) ―Approximately 10 percent of childhood cancer can be attributed to genetics. While genomic analysis has been used for some time to identify the risk of inherited cancer in adults, scientists are now using genomic analysis to identify genetic risk factors and to diagnose cancer at an early age in children. […]

CRISPR – Journal: CRISPR-Based Editing Reveals Edge-Specific Effects in Biological Networks

August 1, 2018

 Yi Li, Chance M. Nowak, Daniel Withers, Alexander Pertsemlidis, Leonidas Bleris Abstract Unraveling the properties of biological networks is central to understanding both normal and disease cellular phenotypes. Networks consist of functional elements (nodes) that form a variety of diverse connections (edges), with each node being a hub for multiple edges. Herein, in contrast to node-centric network perturbation [...]

Cancer Letters: miR-195 potentiates the efficacy of microtubule-targeting agents in non-small cell lung cancer

July 28, 2018

Xiaojie Yuab, Yiqiang Zhanga, Xiuye Maa, Alexander Pertsemlidisabc Abstract Microtubule-targeting agents (MTAs) are widely used for the treatment of non-small cell lung cancer (NSCLC). The response rate is only ∼25%, mainly attributable to drug resistance. To identify the determinants of resistance in NSCLC, we performed a high-throughput screen using a library of miRNA mimics. Here we report that […]

Cancer Letters: Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells

July 1, 2018

AlfeuZanotto-Filhoac  SubapriyaRajamanickama  EvaLoranca  V. Pragathi Masamsettia  AparnaGorthiab  July CarolinaRomeroab  SonalTonapiab  Rosangela Mayer Gonçalvesc  Robert L.Reddickd  RaymondBenavidese  JohnKuhnde  YidongChenf  Alexander J.R.Bishopab Abstract Molecularly targeted compounds are emerging as a strategy to improve classical chemotherapy. Herein, we describe that using a low dose of the multikinase inhibitor sorafenib improves cyclophosphamide antitumor activity by inhibiting angiogenesis, metastasis, and promoting tumor healing in MDA-MB231 xenografts and the 4T1-12B syngeneic breast […]

Express-News: STAR Act is a victory for children with cancer

June 13, 2018

Express-News: STAR Act is a victory for children with cancer Published On: June 13, 2018 Shared by contributor By Gregory J. Aune, MD, PhD For the Express-News President Donald Trump’s signing of the Childhood Cancer Survivorship, Treatment, Access, and Research, or STAR, Act on Tuesday represents a significant legislative achievement in the ongoing battle to improve outcomes […]

Fraternal Order of Eagles: People Helping People

May 18, 2018

2016-17 Texas State Presidents Ron Poling and Rachel Graham were proud to present a check for $50,000 to Dr. Houghton, Director of the Greehey Children’s Cancer Research Institute at the University of Texas Health Science Center in San Antonio. Ron and Rachel would like to thank all the Texas State Aerie and Auxiliary members for […]