Technology Networks: Link Discovered Between BRCA1 Protein and Aggressive Pediatric Cancer

March 8, 2018

Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]


UT Health SA Newsroom: Greehey Institute team finds link between BRCA1 and Ewing sarcoma

March 7, 2018

A mutant oncogene in Ewing traps BRCA1 and prevents it from repairing genetic damage. Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism […]


EurekAlert: Greehey Institute team finds link between BRCA1 and Ewing sarcoma

March 7, 2018

Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]


Life Extension Advocacy Foundation: Greehey Institute team finds link between BRCA1 and Ewing sarcoma

March 7, 2018

Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]


European Urology: Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide

February 10, 2018

Emmanuel S.Antonarakisab†, ChangxueLub†  BrandonLubera  ChaoLiangb  HaoWanga  YanChenb  John L.Silbersteinb DaniloPianab ZhaoLaic YidongChencd William B.Isaacsab JunLuoab Abstract Background Inherited DNA-repair gene mutations are more prevalent in men with advanced prostate cancer than previously thought, but their clinical implications are not fully understood. Objective To investigate the clinical significance of germline DNA-repair gene alterations in men with metastatic castration-resistant prostate cancer (mCRPC) receiving next-generation hormonal […]