PR Stories

Cancer Knowledge Network: Neurocognitive Function, Sleep, and Fatigue in Female Childhood ALL Survivors

July 6, 2017

THE RESEARCH: Cancer: Impact of sleep, fatigue, and systemic inflammation on neurocognitive and behavioral outcomes in long-term survivors of childhood acute lymphoblastic leukemia. Researchers at St. Jude Children’s Research Hospital compiled cohorts of 35 male and 35 female survivors of childhood acute lymphoblastic leukemia with a mean age of 14.3 years and a mean years from […]


Clinical Cancer Research: Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood

July 1, 2017

Maria Isabel Achatz, Christopher C. Porter, Laurence Brugières, Harriet Druker, Thierry Frebourg, William D. Foulkes, Christian P. Kratz, Roland P. Kuiper, Jordan R. Hansford, Hector Salvador Hernandez, Katherine L. Nathanson, Wendy K. Kohlmann, Leslie Doros, Kenan Onel, Kami Wolfe Schneider, Sarah R. Scollon, Uri Tabori, Gail E. Tomlinson, D. Gareth R. Evans and Sharon E. Plon Abstract Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge, especially in childhood. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in […]


Clinical Cancer Research: Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma

July 1, 2017

Jennifer M Kalish 1, Leslie Doros 2, Lee J Helman 3, Raoul C Hennekam 4, Roland P Kuiper 5, Saskia M Maas 6, Eamonn R Maher 7, Kim E Nichols 8, Sharon E Plon 9, Christopher C Porter 10, Surya Rednam 9, Kris Ann P Schultz 11, Lisa J States 12, Gail E Tomlinson 13, Kristin Zelley 14, Todd E Druley 15 Abstract A number of genetic syndromes have been linked to increased risk for Wilms tumor (WT), hepatoblastoma (HB), and other embryonal tumors. Here, we […]


Cancer Knowledge Network: Chemotherapy More Effective at Causing Programmed Cell Death in Young Tissues

June 28, 2017

THE RESEARCH:  Cancer Cell:  Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.  Programmed cell death or apoptosis has been extensively studied in cancerous tissues and is a common mechanism by which tumor cells are killed by radiation and chemotherapy.  In contrast, apoptotic response to chemotherapeutic regimens has not been […]


Cancer Knowledge Network: Pregnancy in Female Cancer Survivors: Increased Risks for Mother and Baby

June 21, 2017

Journal of the National Cancer Institute: Pregnancy and Labor Complications in Female Survivors of Childhood Cancer:  The British Childhood Cancer Survivor Study.  Researchers in the United Kingdom compiled data on pregnancy complications including gestational diabetes, high blood pressure, and anemia in 17,980 female childhood cancer survivors included in the British Childhood Cancer Survivor Study (BCCSS).  […]


Cancer Knowledge Network: Decreased Therapy Results in Fewer Second Cancers

June 15, 2017

JAMA:  Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015.  Investigators from the Childhood Cancer Survivor Study (CCSS) used longitudinal cohort data to compile the 15-year cumulative incidence, cumulative burden, and standardized incidence ratios for 23,603 survivors of childhood cancer.  Patients included in the cohort were diagnosed between 1970 […]


Cancer Knowledge Network: Mental Distress in Survivors: Highly Prevalent and Undertreated

June 8, 2017

Cancer:  Mental distress and health care use among survivors of adolescent and young adult cancer:  A cross-sectional analysis of the National Health Interview Survey. 875 adolescent and young adult cancer survivors were identified from the 2013 and 2014 National Health Interview Survey. This survey is the principal source of information on the overall health status […]


Business Wire: Dogs and Kids Get Many Same Cancers—PAWS for a CURE Summit Explores Finding Common Cures to Help Both

June 7, 2017

47% of dogs die from cancer and more U.S. kids die from cancer than any other disease. Both spontaneously develop a number of similar cancers which are often different than those in adult humans. The first-ever Paws for a Cure Summit, hosted by Canines-N-Kids Foundation, is bringing together top leaders and researchers in veterinary and […]


Cancer Knowledge Network: Childhood Cancer Survivors: Does chemotherapy alone increase second cancer risk?

June 1, 2017

THE RESEARCH: Journal of Clinical Oncology: Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy.  Researchers in the Netherlands identified second cancers in 5-year childhood cancer survivors in the Dutch Childhood Cancer Oncology Group Long-Term Effects After Childhood Cancer (DCOG LATER) cohort. Cumulative incidences of breast […]


Cancer Knowledge Network: First Live Births Less Common in Cancer Survivors

May 25, 2017

THE RESEARCH: Journal of Clinical Oncology:  Reproductive Patterns Among Childhood and Adolescent Cancer Survivors in Sweden: A Population-Based Matched-Cohort Study. Researchers in Sweden compared the probability of first live birth in 1,206 survivors of childhood cancers with 2,412 age-matched controls.  Previous studies assessing fertility outcomes in childhood cancer survivors have focused on treatment regimens, as […]