Greehey Children's Cancer Research Institute
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July 21, 2017
UT Health San Antonio researchers are learning how stem cell biology causes 30 percent of children who have a rare muscle cancer to relapse and not respond to treatment. To do this, the lab of Myron Ignatius, PhD, at UT Health’s Greehey Children’s Cancer Research Institute, is using zebrafish. These fish have the unusual trait […]
July 21, 2017
SAN ANTONIO (July 21, 2017) ― UT Health San Antonio researchers are learning how stem cell biology causes 30 percent of children who have a rare muscle cancer to relapse and not respond to treatment. To do this, the lab of Myron Ignatius, PhD, at UT Health’s Greehey Children’s Cancer Research Institute, is using zebrafish. These fish […]
July 20, 2017
THE RESEARCH: Neurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia Randomly Assigned to Different Methotrexate and Corticosteroid Treatment Strategies: A Report From the Children’s Oncology Group. As part of a clinical trial for high-risk B-acute lymphoblastic leukemia (B-ALL) conducted by Children’s Oncology Group (COG), U.S. researchers performed neurocognitive evaluations on 192 trial participants that […]
July 13, 2017
THE RESEARCH: Journal of the National Cancer Institute: Neurocognitive Sequelae in Adult Childhood Leukemia Survivors Related to Levels of Phosphorylated Tau. Researchers compared intellectual performance, memory, and executive functioning between 31 long-term adult survivors of childhood leukemia and 35 matched control subjects. In addition, correlations were evaluated between these cognitive outcomes and prior dose exposures to […]
July 6, 2017
THE RESEARCH: Cancer: Impact of sleep, fatigue, and systemic inflammation on neurocognitive and behavioral outcomes in long-term survivors of childhood acute lymphoblastic leukemia. Researchers at St. Jude Children’s Research Hospital compiled cohorts of 35 male and 35 female survivors of childhood acute lymphoblastic leukemia with a mean age of 14.3 years and a mean years from […]
July 1, 2017
Maria Isabel Achatz, Christopher C. Porter, Laurence Brugières, Harriet Druker, Thierry Frebourg, William D. Foulkes, Christian P. Kratz, Roland P. Kuiper, Jordan R. Hansford, Hector Salvador Hernandez, Katherine L. Nathanson, Wendy K. Kohlmann, Leslie Doros, Kenan Onel, Kami Wolfe Schneider, Sarah R. Scollon, Uri Tabori, Gail E. Tomlinson, D. Gareth R. Evans and Sharon E. Plon Abstract Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge, especially in childhood. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in […]
July 1, 2017
Jennifer M Kalish 1, Leslie Doros 2, Lee J Helman 3, Raoul C Hennekam 4, Roland P Kuiper 5, Saskia M Maas 6, Eamonn R Maher 7, Kim E Nichols 8, Sharon E Plon 9, Christopher C Porter 10, Surya Rednam 9, Kris Ann P Schultz 11, Lisa J States 12, Gail E Tomlinson 13, Kristin Zelley 14, Todd E Druley 15 Abstract A number of genetic syndromes have been linked to increased risk for Wilms tumor (WT), hepatoblastoma (HB), and other embryonal tumors. Here, we […]
June 28, 2017
THE RESEARCH: Cancer Cell: Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. Programmed cell death or apoptosis has been extensively studied in cancerous tissues and is a common mechanism by which tumor cells are killed by radiation and chemotherapy. In contrast, apoptotic response to chemotherapeutic regimens has not been […]
June 21, 2017
Journal of the National Cancer Institute: Pregnancy and Labor Complications in Female Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study. Researchers in the United Kingdom compiled data on pregnancy complications including gestational diabetes, high blood pressure, and anemia in 17,980 female childhood cancer survivors included in the British Childhood Cancer Survivor Study (BCCSS). […]
June 15, 2017
JAMA: Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015. Investigators from the Childhood Cancer Survivor Study (CCSS) used longitudinal cohort data to compile the 15-year cumulative incidence, cumulative burden, and standardized incidence ratios for 23,603 survivors of childhood cancer. Patients included in the cohort were diagnosed between 1970 […]