Cancer Knowledge Network: Chemotherapy More Effective at Causing Programmed Cell Death in Young Tissues

June 28, 2017

THE RESEARCH:  Cancer Cell:  Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.  Programmed cell death or apoptosis has been extensively studied in cancerous tissues and is a common mechanism by which tumor cells are killed by radiation and chemotherapy.  In contrast, apoptotic response to chemotherapeutic regimens has not been […]

Cancer Knowledge Network: Pregnancy in Female Cancer Survivors: Increased Risks for Mother and Baby

June 21, 2017

Journal of the National Cancer Institute: Pregnancy and Labor Complications in Female Survivors of Childhood Cancer:  The British Childhood Cancer Survivor Study.  Researchers in the United Kingdom compiled data on pregnancy complications including gestational diabetes, high blood pressure, and anemia in 17,980 female childhood cancer survivors included in the British Childhood Cancer Survivor Study (BCCSS).  […]

Cancer Knowledge Network: Decreased Therapy Results in Fewer Second Cancers

June 15, 2017

JAMA:  Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015.  Investigators from the Childhood Cancer Survivor Study (CCSS) used longitudinal cohort data to compile the 15-year cumulative incidence, cumulative burden, and standardized incidence ratios for 23,603 survivors of childhood cancer.  Patients included in the cohort were diagnosed between 1970 […]

Cancer Knowledge Network: Mental Distress in Survivors: Highly Prevalent and Undertreated

June 8, 2017

Cancer:  Mental distress and health care use among survivors of adolescent and young adult cancer:  A cross-sectional analysis of the National Health Interview Survey. 875 adolescent and young adult cancer survivors were identified from the 2013 and 2014 National Health Interview Survey. This survey is the principal source of information on the overall health status […]

Business Wire: Dogs and Kids Get Many Same Cancers—PAWS for a CURE Summit Explores Finding Common Cures to Help Both

June 7, 2017

47% of dogs die from cancer and more U.S. kids die from cancer than any other disease. Both spontaneously develop a number of similar cancers which are often different than those in adult humans. The first-ever Paws for a Cure Summit, hosted by Canines-N-Kids Foundation, is bringing together top leaders and researchers in veterinary and […]

Cancer Knowledge Network: Childhood Cancer Survivors: Does chemotherapy alone increase second cancer risk?

June 1, 2017

THE RESEARCH: Journal of Clinical Oncology: Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy.  Researchers in the Netherlands identified second cancers in 5-year childhood cancer survivors in the Dutch Childhood Cancer Oncology Group Long-Term Effects After Childhood Cancer (DCOG LATER) cohort. Cumulative incidences of breast […]

Cancer Knowledge Network: First Live Births Less Common in Cancer Survivors

May 25, 2017

THE RESEARCH: Journal of Clinical Oncology:  Reproductive Patterns Among Childhood and Adolescent Cancer Survivors in Sweden: A Population-Based Matched-Cohort Study. Researchers in Sweden compared the probability of first live birth in 1,206 survivors of childhood cancers with 2,412 age-matched controls.  Previous studies assessing fertility outcomes in childhood cancer survivors have focused on treatment regimens, as […]

Cancer Knowledge Network: Hodgkin Lymphoma Survivors at High Risk of Second Cancers

May 18, 2017

THE RESEARCH: The Journal of Clinical Oncology:  Risk of Second Cancer in Hodgkin Lymphoma Survivors and the Influence of Family History.  Researchers in the European countries of the United Kingdom, Germany, and Sweden collaborated to study rates of secondary cancers in 9,522 Hodgkin lymphoma (HL) survivors identified in the Swedish Family-Cancer Project Database.  The researchers […]

Cancer Knowledge Network: What Factors are Associated with Hearing Loss in Childhood Cancer Survivors Treated with Platinum Agents?

May 4, 2017

THE RESEARCH:  Determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer:  A DCOG late-effects study.  Researchers compiled treatment data and audiograms from 451 childhood cancer survivors (CCS) treated at seven pediatric oncology centers in the Netherlands.  The study focused on identifying patients that had received platinum agents without cranial irradiation since no previous studies […]

Scientia: Dr Peter Houghton – Novel Therapeutics For Childhood Solid Tumours

February 15, 2017

Dr Peter Houghton’s group implements preclinical trials to identify new drugs that may be effective and less toxic treatments against childhood cancers. From patient-derived xenografts in immunodeficient mice to utilising canine cancer patients as models, they have identified over 80 new drugs or drug combinations for the treatment of these diseases. Solid tumours in children Approximately […]