Greehey Children's Cancer Research Institute
Category
August 10, 2017
The key to finding a better way to treat a deadly form of childhood cancer may lie in a tiny fish. An unlikely animal model at UT Health San Antonio is helping scientists figure out how to tackle muscle tumors. Inside a fish lab at the Greehey Children’s Cancer Research Institute, rows and rows of glass tanks are […]
August 3, 2017
Pediatric Blood and Cancer: Risk factors and surveillance for reduced bone mineral density in pediatric cancer survivors. Between 2003 and 2010, 475 survivors of childhood leukemia and solid tumors (excluding central nervous system tumors) were screened for decreased bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA). These screenings were conducted according to the consensus-based Children’s […]
July 27, 2017
Journal of Clinical Oncology: Endocrine Abnormalities in Aging Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. Researchers in the United States analyzed the frequency of a range of endocrine disorders reported by 14,290 5-year survivors included in the Childhood Cancer Survivor Study (CCSS). Subjects included in the analysis had a median […]
July 21, 2017
UT Health San Antonio researchers are learning how stem cell biology causes 30 percent of children who have a rare muscle cancer to relapse and not respond to treatment. To do this, the lab of Myron Ignatius, PhD, at UT Health’s Greehey Children’s Cancer Research Institute, is using zebrafish. These fish have the unusual trait […]
July 21, 2017
SAN ANTONIO (July 21, 2017) ― UT Health San Antonio researchers are learning how stem cell biology causes 30 percent of children who have a rare muscle cancer to relapse and not respond to treatment. To do this, the lab of Myron Ignatius, PhD, at UT Health’s Greehey Children’s Cancer Research Institute, is using zebrafish. These fish […]
July 20, 2017
THE RESEARCH: Neurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia Randomly Assigned to Different Methotrexate and Corticosteroid Treatment Strategies: A Report From the Children’s Oncology Group. As part of a clinical trial for high-risk B-acute lymphoblastic leukemia (B-ALL) conducted by Children’s Oncology Group (COG), U.S. researchers performed neurocognitive evaluations on 192 trial participants that […]
July 15, 2017
Luke Jones 1, Jennifer Richmond 1, Kathryn Evans 1, Hernan Carol 1, Duohui Jing 1, Raushan T Kurmasheva 2, Catherine A Billups 3, Peter J Houghton 2, Malcolm A Smith 4, Richard B Lock 5 Abstract Purpose: Robust preclinical models of pediatric acute lymphoblastic leukemia (ALL) are essential in prioritizing promising therapies for clinical assessment in high-risk patients. Patient-derived xenograft (PDX) models of ALL provide a clinically relevant platform for assessing novel drugs, with […]
July 13, 2017
THE RESEARCH: Journal of the National Cancer Institute: Neurocognitive Sequelae in Adult Childhood Leukemia Survivors Related to Levels of Phosphorylated Tau. Researchers compared intellectual performance, memory, and executive functioning between 31 long-term adult survivors of childhood leukemia and 35 matched control subjects. In addition, correlations were evaluated between these cognitive outcomes and prior dose exposures to […]
July 6, 2017
THE RESEARCH: Cancer: Impact of sleep, fatigue, and systemic inflammation on neurocognitive and behavioral outcomes in long-term survivors of childhood acute lymphoblastic leukemia. Researchers at St. Jude Children’s Research Hospital compiled cohorts of 35 male and 35 female survivors of childhood acute lymphoblastic leukemia with a mean age of 14.3 years and a mean years from […]
July 1, 2017
Maria Isabel Achatz, Christopher C. Porter, Laurence Brugières, Harriet Druker, Thierry Frebourg, William D. Foulkes, Christian P. Kratz, Roland P. Kuiper, Jordan R. Hansford, Hector Salvador Hernandez, Katherine L. Nathanson, Wendy K. Kohlmann, Leslie Doros, Kenan Onel, Kami Wolfe Schneider, Sarah R. Scollon, Uri Tabori, Gail E. Tomlinson, D. Gareth R. Evans and Sharon E. Plon Abstract Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge, especially in childhood. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in […]