PNAS: Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility

November 24, 2020

Yuan Lu,  View ORCID ProfileAngel Sandoval,  View ORCID ProfileSarah Voss, Zhao Lai, Susanne Kneitz, Will Boswell, Mikki Boswell, Markita Savage,  View ORCID ProfileChristi Walter, Wes Warren,  View ORCID ProfileManfred Schartl, and Ronald Walter Abstract Mixing genomes of different species by hybridization can disrupt species-specific genetic interactions that were adapted and fixed within each species population. Such disruption can predispose the hybrids to abnormalities and disease that […]

Mucosal Immunology: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion

November 19, 2020

Wayne T. Muraoka, Anna A. Korchagina, Qingqing Xia, Sergey A. Shein, Xi Jing, Zhao Lai, Korri S. Weldon, Li-Ju Wang, Yidong Chen, Lawrence W. Kummer, Markus Mohrs, Eric Vivier, Ekaterina P. Koroleva & Alexei V. Tumanov Abstract Innate lymphoid cells (ILCs) are a heterogeneous family of immune regulators that protect against mucosal pathogens but can also […]

Nature Communications: Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells (Pertsemlidis)

November 16, 2020

Justin B. Moroney, Anusha Vasudev, Alexander Pertsemlidis, Hong Zan & Paolo Casali Abstract Memory B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched antibodies. Here, we use a multiparameter approach involving CD27 to segregate naïve B cells (NBC), IgD+ unswitched (unsw)MBCs, and IgG+ or IgA+ class-switched (sw)MBCs from humans of different age, sex and race. Conserved antibody variable gene expression […]

Argonne National Laboratory: Hide and Seek: Understanding How COVID-19 Evades Detection in a Human Cell (Gupta)

November 3, 2020

BY ANDRE SALLES |OCTOBER 29, 2020 Scientists using the Advanced Photon Source have discovered new insights into the ways the SARS-CoV-2 virus camouflages itself inside the human body. Scientists around the world have been working for months to identify and develop treatments that combat SARS-CoV-2, the virus that causes COVID-19. An important part of that process […]

Cell Reports: GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth

November 3, 2020

Fuchun Zhou (1), David J.Elzi (1, 2), Panneerselvam Jayabal(1), Xiuye Ma(1), Yu-Chiao Chiu (1) Yidong Chen 1,3,4) Barron Blackman(1) Susan T.Weintraub (4, 5) Peter J.Houghton 1,4,6) Yuzuru Shiio (1,4,5,7) Highlights The autocrine signaling mediated by GDF6 maintains Ewing sarcoma growth The GDF6 prodomain is a ligand for CD99, a widely used marker for Ewing sarcoma […]

ECancer Interview: Prospective validation of single mouse testing by the paediatric preclinical testing consortium (Houghton)

October 24, 2020

Dr. Peter Houghton speaks to ecancer about the prospective validation of single mouse testing by the pediatric preclinical testing consortium; a study that was presented at ENA 2020 this year. Dr. Houghton initially explains the rationale behind this study and talks about how it was tested that using a single mouse for studying drug efficacy [...]

MedicalXpress – One Mouse at a Time: a New Approach to Testing Potential Drugs for Children’s Cancers (Houghton, Kurmasheva, PPTC)

October 22, 2020

by European Organisation for Research and Treatment of Cancer A team of researchers in the US and Australia have developed a way of testing potential drugs for children’s cancers so as to take account of the wide genetic diversity of these diseases. In new research to be presented at the 32nd EORTC-NCI-AACR Symposium on Molecular […]

Stand Up to Cancer: Alexander J. R. Bishop, DPhil to Lead One of Three Trans-Atlantic Teams to Study Hard-to-Treat Childhood Cancers

October 20, 2020

Published On: October 19, 2020 Shared by Rosanne Fohn SAN ANTONIO (Oct. 19, 2020) — Although COVID-19 has become the top health and research priority around the world, a child is still diagnosed with cancer every two minutes globally. To meet this urgent need, the Stand Up To Cancer and Cancer Research UK’s Pediatric Cancer New [...]

Pediatric Blood & Cancer: Radiation therapy and molecular‐targeted agents in preclinical testing for immunotherapy, brain tumors, and sarcomas: Opportunities and challenges (Houghton)

October 14, 2020

Radiation therapy and molecular‐targeted agents in preclinical testing for immunotherapy, brain tumors, and sarcomas: Opportunities and challenges Ralph Vatner, Charles D. James, Vythialingam Sathiaseelan, Kathryn M. Bondra, John A. Kalapurakal, Peter J. Houghton Abstract Despite radiation therapy (RT) being an integral part of the treatment of most pediatric cancers and the recent discovery of novel […]

Breast Cancer Research and Treatment: KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer

October 14, 2020

Abstract Purpose Cancer stem cells (CSCs) are highly tumorigenic, spared by chemotherapy, sustain tumor growth, and are implicated in tumor recurrence after conventional therapies in triple-negative breast cancer (TNBC). Lysine-specific histone demethylase 1A (KDM1A) is highly expressed in several human malignancies and CSCs including TNBC. However, the precise mechanistic role of KDM1A in CSC functions [...]