Greehey Children's Cancer Research Institute
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March 2, 2020
Yu-Chiao Chiu, PhD, a postdoctoral researcher at the Greehey Children’s Cancer Research Institute (GCCRI), received the prestigious NIH Pathway to Independence Award (K99/R00) from the National Cancer Institute (NCI). The highly competitive NIH grant is awarded to about 30 outstanding cancer researchers nationwide each year for them to complete mentored training (K99 […]
March 1, 2020
Shaofang Wu 1, Feng Gao 1, Siyuan Zheng 2, Chen Zhang 1, Emmanuel Martinez-Ledesma 1 3, Ravesanker Ezhilarasan 4, Jie Ding 1, Xiaolong Li 1, Ningping Feng 5, Asha Multani 6, Erik P Sulman 4, Roel G Verhaak 2, John F de Groot 1, Tim P Heffernan 5, W K Alfred Yung 1, Dimpy Koul 7 Abstract Purpose: Exploration of novel strategies to extend the benefit of PARP inhibitors beyond BRCA-mutant cancers is of great interest in personalized medicine. Here, we identified EGFR amplification as a potential biomarker to predict sensitivity […]
February 27, 2020
CPRIT officials said this is one of the largest amounts San Antonio institutions have collectively received from the institute in a single funding round since it was established by Texas voters in 2007. CPRIT CEO Wayne Roberts said it’s also further indication that the Alamo City “continues to expand its cancer research and prevention prowess.”
February 25, 2020
Dr. Manjeet Rao, Greehey CCRI Deputy Director (interim), was recently awarded a grant from National Cancer Institute ($2.1 million) to test the therapeutic efficacy of a novel drug that can inhibit the function of a protein that is highly expressed in cancers. Cancer cells use various mechanisms to manage their survival such as repairing DNA […]
February 24, 2020
Written by: Will Sansom An award of $1.2 million from the Cancer Prevention and Research Institute of Texas (CPRIT) went to Greehey CCRI Deputy Director and principal investigator Manjeet Rao, PhD, professor of cell systems and anatomy, for studies of an enzyme protein that helps osteosarcoma cells to survive and spread. The team, which includes co-principal investigator Yogesh Gupta, […]
February 22, 2020
“Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles” Abstract Therapy resistance and recurrence in high-grade gliomas are driven by their populations of glioma stem cells (GSCs). Thus, detailed molecular characterization of GSCs is needed to develop more effective therapies. We conducted a study to identify differences in the splicing […]
February 20, 2020
CPRIT officials said this is one of the largest collective awards the Alamo City has received in a single funding round.
February 18, 2020
Michael A. Liss,1 Yidong Chen,2 Ronald Rodriguez,1 Deepak Pruthi,1 Teresa Johnson-Pais,3 Hanzhang Wang,1 Ahmed Mansour,1 James R. White,4 and Dharam Kaushik1 Abstract Objective. To perform a proof of concept microbiome evaluation and PD-L1 expression profiling in clear-cell renal cell carcinoma (cc-RCC) with associated tumor thrombus (TT). Methods. After IRB approval, six patients underwent radical nephrectomy (RN) with venous tumor thrombectomy (VTT). We collected fresh tissue […]
February 6, 2020
Zhe Zhu, Pinar Mesci, Jean A Bernatchez, Ryan C Gimple, Xiuxing Wang, Simon T Schafer, Hiromi I Wettersten, Sungjun Beck, Alex E Clark, Qiulian Wu, Briana C Prager, Leo JY Kim, Rekha Dhanwani, Sonia Sharma, Alexandra Garancher, Sara M Weis, Stephen C Mack, Priscilla D Negraes, Cleber A Trujillo, Luiz O Penalva, Jing Feng, Zhou […]
January 2, 2020
Sulgi Park, Chung-Seog Song, Chun-Lin Lin, Shoulei Jiang, Pawel A Osmulski, Chiou-Miin Wang, Brett T Marck, Alvin M Matsumoto, Colm Morrissey, Maria E Gaczynska, Yidong Chen, Elahe A Mostaghel, Bandana Chatterjee Abstract SULT2B1b (SULT2B) is a prostate-expressed hydroxysteroid sulfotransferase, which may regulate intracrine androgen homeostasis by mediating 3β-sulfation of dehydroepiandrosterone (DHEA), the precursor for 5α-dihydrotestosterone (DHT) biosynthesis. The aldo-keto reductase (AKR)1C3 regulates androgen receptor (AR) activity in […]