Research Paper
NewsWeek: Coronavirus Disguises Itself to Hide Inside Our Cells and Replicate
July 24, 2020
The COVID-19-causing coronavirus disguises itself so it can hide inside our cells without being detected by the immune system in order to replicate, according to a study. For the paper published in the journal Nature Communications, scientists examined the 3D structure of a protein called nsp16 that the coronavirus creates.
Scitech Daily: SARS-CoV-2 Coronavirus Has a “Camouflage” That Causes Cells Not to Recognize It – “Fundamental Advance in Our Understanding of the Virus”
July 24, 2020
With an alarm code, we can enter a building without bells going off. It turns out that the SARS coronavirus 2 (SARS-CoV-2) has the same advantage in entering cells. It possesses the code to waltz right in. Today (July 24, 2020), in Nature Communications, researchers at The University of Texas Health Science Center at San Antonio […]
ArzteZeitung: Current corona studies: Fatigue as a long-term consequence in every second COVID-19 patient (Gupta)
July 22, 2020
Persistent fatigue as a result of COVID-19 could be widespread. According to a small study, persistent tiredness and exhaustion are quite common consequences of having suffered COVID-19. Women are more often affected than men, report researchers led by Dr. Liam Townsend from Trinity College Dublin. Of 128 study participants, a little more than half (52.3 percent) felt bruised for […]
Nature Communications: Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution (Zheng)
July 22, 2020
Yinghua Li 1 2 3, Bo Li 4, Wei Li 5, Yuan Wang 1 2 3, Seçkin Akgül 1 2 3 6 7, Daniel M Treisman 1 2 3 6, Kevin A Heist 8, Brianna R Pierce 1 2 3, Benjamin Hoff 8, Cheng-Ying Ho 5, David O Ferguson 9, Alnawaz Rehemtulla 10, Siyuan Zheng 11, Brian D Ross 8, Jun Z Li 4, Yuan Zhu 12 13 14 15 16 Abstract Recent characterization of the spatiotemporal genomic architecture of IDH-wild-type multifocal glioblastomas (M-GBMs) suggests a clinically unobserved common ancestor (CA) with a less aggressive phenotype, generating highly genetically divergent malignant gliomas/GBMs in […]
eCancer: Finding hints at novel target for Ewing sarcoma therapy
July 17, 2020
New insights into Ewing sarcoma, an aggressive childhood cancer, were published in the journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily affects children and adolescents.
SCIENCE DAILY: Finding hints at novel target for Ewing sarcoma therapy
July 17, 2020
Originally Published by: Science Daily New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily […]
UT Health SA Newsroom: Finding published in Nature hints at novel therapeutic target for Ewing sarcoma
July 16, 2020
New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the prestigious journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily affects children and adolescents. The […]
Alexander J.R. Bishop, DPhil. & Aparna Gorthi, PhD, Co-Author Nature Research Paper
July 15, 2020
Bishop Gorthi “Nucleolar RNA Polymerase II Drives Ribosome Biogenesis” Publication Date: July 15, 2020 Abstract Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli1,2. Existing models suggest that RNA polymerases I and III (Pol […]
Nature: Nucleolar RNA polymerase II drives ribosome biogenesis
July 15, 2020
Karan J. Abraham, Negin Khosraviani, Janet N. Y. Chan, Aparna Gorthi, Anas Samman, Dorothy Y. Zhao, Miling Wang, Michael Bokros, Elva Vidya, Lauren A. Ostrowski, Roxanne Oshidari, Violena Pietrobon, Parasvi S. Patel, Arash Algouneh, Rajat Singhania, Yupeng Liu, V. Talya Yerlici, Daniel D. De Carvalho, Michael Ohh, Brendan C. Dickson, Razq Hakem, Jack F. Greenblatt, […]
Oncotarget: Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway
July 7, 2020
Ashley VanCleave 1, Mykayla Palmer 1 2, Fang Fang 1, Haydee Torres 1 3, Tania Rodezno 1, Qilin Li 4, Kirby Fuglsby 1 5, Claire Evans 1, Yohannes Afeworki 6, Alan Ross 7, Pulivarthi Rao 8, Patricia Leiferman 9 10, Siyuan Zheng 4, Peter Houghton 4, Jianning Tao 1 3 5 10 Abstract Outcomes have not improved for metastatic osteosarcoma for several decades. In part, this failure to develop better therapies stems from a lack of understanding of osteosarcoma biology, given the rarity of the disease and the high genetic heterogeneity […]