Cold Spring Harbor Molecular Case Studies: Bloom syndrome in a Mexican-American family with rhabdomyosarcoma: evidence of a Mexican founder mutation (Bishop, Chen, Tomlinson)

April 9, 2021

Erin H. Sybouts1,2,11, Adam D. Brown1,2,8,11, Maria G. Falcon-Cantrill3,9,11, Martha H. Thomas1,10, Thomas DeNapoli4,5, Julie Voeller5,6, Yidong Chen1,7, Gail E. Tomlinson1,3 and Alexander J.R. Bishop1,2 Abstract Bloom syndrome is a rare autosomal recessive disorder with less than 300 cases reported in the literature. Bloom syndrome is characterized by chromosome instability, physical stigmata, growth deficiency, immunodeficiency, and […]

MDPI: Samson Ghilu, Raushan Kurmasheva, and Peter Houghton publish a perspective on developing new agents for treatment of childhood cancer, and its challenges and opportunities for preclinical testing

April 4, 2021

Abstract Developing new therapeutics for the treatment of childhood cancer has challenges not usually associated with adult malignancies. Firstly, childhood cancer is rare, with approximately 12,500 new diagnoses annually in the U.S. in children 18 years or younger. With current multimodality treatments, the 5-year event-free survival exceeds 80%, and 70% of patients achieve long-term “cure”, […]

Cancer Letters: COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice (Bishop)

April 1, 2021

Rosângela MayerGonçalvesa, Marina Delgoboa, Jonathan Paulo Agnesa, Raquel Nascimento das Nevesa, MarceloFalchettia, Tuany Casagrandea, Ana Paula Vargas Garciab, Thaynan Cunha Vieirab, Nauana Somensic, Maciel Alencar Bruxeld, Daniel Augusto Gasparin Bueno Mendese, Alex Rafachod, André Báficae, Daniel Pens, Gelainc, José Cláudio Fonseca, Moreirac, Geovanni Dantas Cassalib, Alexander James Roy Bishopf, AlfeuZanotto-Filhoa Abstract Obesity is a major […]

Cancer Research: Deciphering the role of intestinal crypt cell populations in resistance to chemotherapy (Penalva Lab)

March 30, 2021

Carla Frau, Catherine Jamard, Gaspard Delpouve, Gabriela D. A. Guardia, Christelle Machon, Camilla Pilati, Clementine Le Neve, Pierre Laurent-Puig, Jérôme Guitton, Pedro A. F. Galante, Luiz O. Penalva, Jean-Noel Freund, Christelle de la Fouchardière and Michelina Plateroti Abstract Intestinal crypts are composed of heterogeneous and highly plastic cell populations. Lgr5high-stem cells (SC) are responsible for homeostatic renewal, but other cells can revert to an SC-like phenotype to maintain epithelial integrity. Despite their distinct roles in orchestrating homeostasis, both populations have been designated as […]

Development: The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway (Penalva Lab)

March 30, 2021

Matthias Godart, Carla Frau, Diana Farhat, Maria Virginia Giolito, Catherine Jamard, Clementine Le Nevé, Jean-Noel Freund, Luiz O. Penalva, Maria Sirakov, Michelina Plateroti Abstract The thyroid hormone T3 and its nuclear receptor TRα1 control gut development and homeostasis through the modulation of intestinal crypt cell proliferation. Despite increasing data, in-depth analysis on their specific action on intestinal stem cells is lacking. By using ex vivo 3D […]

MDPI: Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes (Penalva Lab)

March 30, 2021

Mirella Baroni 1,†,  OrcID,Caihong Yi 1,2,†,  Saket Choudhary 3,†,  Xiufen Lei 1,  Adam Kosti 1,4,   Denise Grieshober 1,  Mitzli Velasco 1,  Mei Qiao 1,  Suzanne S. Burns 1,‡,  Patricia R. Araujo 1,  Talia DeLambre 1,  Mi Young Son 5,  Michelina Plateroti 6,  Marco A. R. Ferreira 7,  Paul Hasty 5,  and. Luiz O. F. Penalva […]

Cell Cycle: Regulation of DNA duplication by the mTOR signaling pathway (Houghton)

March 11, 2021

ABSTRACT Accurate and complete DNA replication and separation are essential for genetic information inheritance and organism maintenance. Errors in DNA duplication are the main source of genetic instability. Understanding DNA duplication regulation is the key to elucidate the mechanisms and find treatment strategies for human genetic disorders, especially cancer. The mechanistic target of rapamycin (mTOR) […]

Nighat Noureen, PhD, Awarded CPRIT Postdoctoral Training Award (Zheng Lab)

March 10, 2021

    Congratulations to Nighat Noureen, PhD, a postdoctoral fellow in the lab of Greehey CCRI principal investigator, Siyuan Zheng, PhD, on recently being awarded a CPRIT fellowship training grant. Dr. Noureen joined Dr. Zheng’s lab in June 2018. Her first project was to develop a computational method to quantify telomerase activity in cancer and […]

Dr. Yogesh Gupta Delivers COVID Presentation to International Society for Stem Cell Research

February 26, 2021

    On February 25, 2021, Dr. Yogesh Gupta delivered an invited talk at the International Society for Stem Cell Research COVID network meeting chaired by Hans-Willem Snoeck. MD, PhD (Columbia Univ.) and Todd McDevitt, PhD (Gladstone Inst., UCSF). At this meeting, Dr. Gupta presented his recent research on nonstructural proteins (nsps) of SARS-CoV-2. Some […]

FASEB Journal: Identification of a novel mechanism for meso‐tetra (4‐carboxyphenyl) porphyrin (TCPP) uptake in cancer cells

February 25, 2021

            David J. Elzi,   William E. Bauta,  Jamila R. Sanchez,  Trisha Das, Shweta Mogare, Peter Zannes Fatland,  Moises Iza, Alexander Pertsemlidis,  Vivienne I. Rebel  Abstract Porphyrins are used for cancer diagnostic and therapeutic applications, but the mechanism of how porphyrins accumulate in cancer cells remains elusive. Knowledge of how porphyrins […]