Nature Communications: Structural basis of RNA cap modification by SARS-CoV-2

July 24, 2020

Thiruselvam Viswanathan, Shailee Arya, Siu-Hong Chan, Shan Qi, Nan Dai, Anurag Misra, Jun-Gyu Park, Fatai Oladunni, Dmytro Kovalskyy, Robert A. Hromas, Luis Martinez-Sobrido & Yogesh K. Gupta Nature Communications volume 11, Article number: 3718 (2020) Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 illness, has caused millions of infections worldwide. In […]

NewsWeek: Coronavirus Disguises Itself to Hide Inside Our Cells and Replicate

July 24, 2020

The COVID-19-causing coronavirus disguises itself so it can hide inside our cells without being detected by the immune system in order to replicate, according to a study. For the paper published in the journal Nature Communications, scientists examined the 3D structure of a protein called nsp16 that the coronavirus creates.

Scitech Daily: SARS-CoV-2 Coronavirus Has a “Camouflage” That Causes Cells Not to Recognize It – “Fundamental Advance in Our Understanding of the Virus”

July 24, 2020

With an alarm code, we can enter a building without bells going off. It turns out that the SARS coronavirus 2 (SARS-CoV-2) has the same advantage in entering cells. It possesses the code to waltz right in. Today (July 24, 2020), in Nature Communications, researchers at The University of Texas Health Science Center at San Antonio […]

ArzteZeitung: Current corona studies: Fatigue as a long-term consequence in every second COVID-19 patient (Gupta)

July 22, 2020

Persistent fatigue as a result of COVID-19 could be widespread. According to a small study, persistent tiredness and exhaustion are quite common consequences of having suffered COVID-19. Women are more often affected than men, report researchers led by Dr. Liam Townsend from Trinity College Dublin. Of 128 study participants, a little more than half (52.3 percent) felt bruised for […]

Nature Communications: Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution (Zheng)

July 22, 2020

Yinghua Li 1 2 3, Bo Li 4, Wei Li 5, Yuan Wang 1 2 3, Seçkin Akgül 1 2 3 6 7, Daniel M Treisman 1 2 3 6, Kevin A Heist 8, Brianna R Pierce 1 2 3, Benjamin Hoff 8, Cheng-Ying Ho 5, David O Ferguson 9, Alnawaz Rehemtulla 10, Siyuan Zheng 11, Brian D Ross 8, Jun Z Li 4, Yuan Zhu 12 13 14 15 16 Abstract Recent characterization of the spatiotemporal genomic architecture of IDH-wild-type multifocal glioblastomas (M-GBMs) suggests a clinically unobserved common ancestor (CA) with a less aggressive phenotype, generating highly genetically divergent malignant gliomas/GBMs in […]

eCancer: Finding hints at novel target for Ewing sarcoma therapy

July 17, 2020

New insights into Ewing sarcoma, an aggressive childhood cancer, were published in the journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily affects children and adolescents.

SCIENCE DAILY: Finding hints at novel target for Ewing sarcoma therapy

July 17, 2020

Originally Published by: Science Daily New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily […]

Alexander J.R. Bishop, DPhil. & Aparna Gorthi, PhD, Co-Author Nature Research Paper

July 15, 2020

   Bishop                    Gorthi “Nucleolar RNA Polymerase II Drives Ribosome Biogenesis” Publication Date: July 15, 2020 Abstract Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli1,2. Existing models suggest that RNA polymerases I and III (Pol […]

Nature: Nucleolar RNA polymerase II drives ribosome biogenesis

July 15, 2020

Karan J. Abraham, Negin Khosraviani, Janet N. Y. Chan, Aparna Gorthi, Anas Samman, Dorothy Y. Zhao, Miling Wang, Michael Bokros, Elva Vidya, Lauren A. Ostrowski, Roxanne Oshidari, Violena Pietrobon, Parasvi S. Patel, Arash Algouneh, Rajat Singhania, Yupeng Liu, V. Talya Yerlici, Daniel D. De Carvalho, Michael Ohh, Brendan C. Dickson, Razq Hakem, Jack F. Greenblatt, […]