Greehey Children's Cancer Research Institute
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September 30, 2020
Trevi Mancilla, a student in the South Texas Medical Scientist Training Program, has published a first-author publication in PLOS ONE. The title is “Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts.” Her mentor is Dr. Greg Aune. We interviewed Trevi about her recent achievement.
September 30, 2020
Undergoing chemotherapy can have a negative impact on the cells responsible for repairing heart damage, according to a new study published in PLOS One. This may explain why 20% of children treated with anthracyclines go on to experience heart failure later in life. “We don’t fully understand why some children who are exposed to anthracycline therapy […]
September 30, 2020
by Will Sansom, UT Health San Antonio Cancer chemotherapy changes the function of cells that repair heart injury, researchers at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) discovered. Twenty percent of children treated with drugs called anthracyclines go on to suffer heart failure later in life. The journal […]
September 23, 2020
Jennifer Mecklenburg 1, Yi Zou 2, Andi Wangzhou 3, Dawn Garcia 2, Zhao Lai 2 4, Alexei V Tumanov 5, Gregory Dussor 3, Theodore J Price 3, Armen N Akopian 6 7 Abstract Many chronic pain conditions show sex differences in their epidemiology. This could be attributed to the sex-dependent differential expression of genes (DEGs) involved in nociceptive pathways, including sensory neurons. This study aimed to identify sex-dependent DEGs in estrous female versus male […]
September 22, 2020
T. R. Mancilla, L. R. Davis, G. J. Aune Abstract Anthracyclines are the critical component in a majority of pediatric chemotherapy regimens due to their broad anticancer efficacy. Unfortunately, the vast majority of long-term childhood cancer survivors will develop a chronic health condition caused by their successful treatments and severe cardiac disease is a common life-threatening outcome […]
September 17, 2020
Jennifer Mecklenburg 1, Yi Zou 2, Andi Wangzhou 3, Dawn Garcia 2, Zhao Lai 2 4, Alexei V Tumanov 5, Gregory Dussor 3, Theodore J Price 3, Armen N Akopian 6 7 Abstract Many chronic pain conditions show sex differences in their epidemiology. This could be attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive pathways, including sensory neurons. This study aimed to identify sex-dependent DEGs in estrous female versus male sensory […]
September 8, 2020
SOURCE: UT Health San Antonio Newsroom “The following are the additional researchers and their awards: Dmitri Ivanov, PhD, associate professor of biochemistry and structural biology, will receive an Individual Investigator Research Award for Cancer in Children and Adolescents in the amount of $1,198,659. The topic is “Enhancing Cytarabine Response Through SAMHD1 Inhibition.” Dr. Ivanov’s team […]
September 8, 2020
Juechen Yang, Qilin Li, Nighat Noureen (Greehey CCRI, Zheng Lab), Yanbing Fang, Raushan Kurmasheva (Greehey CCRI, Kurmasheva Lab), Peter J Houghton (Greehey CCRI, Houghton Lab), Xiaojing Wang (Greehey CCRI, Wang Lab), Siyuan Zheng (Greehey CCRI, Zheng Lab) Nucleic Acids Research, gkaa698, https://doi.org/10.1093/nar/gkaa698 Published: 18 August 2020 Abstract Although cancer is the leading cause of disease-related mortality in […]
August 26, 2020
As we all know too well, the virus SARS-CoV-2 causes severe respiratory illness COVID-19. In parallel with the critical search for a cure, scientists are working diligently to develop effective treatments that can help lower the morbidity of this deadly virus. To develop these therapeutics, we must understand how the virus is able to invade […]
August 20, 2020
PROJECT SUMMARY Glioblastoma (GBM) is the most common and most aggressive brain tumor type among adults with a 14 months average patient survival. Despite all genomic efforts in recent years, novel therapies based on GBM common mutations and alterations have been disappointing. To build an alternative route, we have been focusing on oncogenic RNA binding […]