Greehey Children's Cancer Research Institute
Category
June 25, 2019
In March 2016, Dr. Zhao Lai was awarded $600,000 NIH Shared Instrument grant (S10 grant 1S10OD021805-01) to purchase Illumina HiSeq 3000 to upgrade the sequencing platform in GSF. Illumina HiSeq 3000/4000(3000 carries one flow cell vs HiSeq 4000 with two flow cell stations) is the latest and most efficient sequencing platform in Illumina NGS market. […]
June 21, 2019
Marielle E Yohe 1, Christine M Heske 1, Elizabeth Stewart 2, Peter C Adamson 3, Nabil Ahmed 4, Cristina R Antonescu 5, Eleanor Chen 6, Natalie Collins 7, Alan Ehrlich 8, Rene L Galindo 9, Berkley E Gryder 1, Heidi Hahn 10, Sharon Hammond 11, Mark E Hatley 2, Douglas S Hawkins 12, Madeline N Hayes 13, Andrea Hayes-Jordan 14, Lee J Helman 15, Simone Hettmer 16, Myron S Ignatius 17, Charles Keller 18, Javed Khan 1, David G Kirsch 19, Corinne M Linardic 19, Philip J Lupo 4, Rossella Rota 20, Jack F Shern 1, Janet Shipley 21, Sivasish Sindiri 1, Stephen J Tapscott 22, Christopher R Vakoc 23, Leonard H Wexler 5, David M Langenau 13 Abstract Overall […]
June 12, 2019
Trevi R. Mancilla, Brian Iskra, Gregory J. Aune ABSTRACT Doxorubicin‐induced cardiotoxicity in childhood cancer survivors is a growing problem. The population of patients at risk for cardiovascular disease is steadily increasing, as five‐year survival rates for all types of childhood cancers continue to improve. Doxorubicin affects the developing heart differently from the adult heart and in a […]
June 1, 2019
Yael P Mossé 1 2, Elizabeth Fox 3 2, David T Teachey 3 2, Joel M Reid 4, Stephanie L Safgren 4, Hernan Carol 5, Richard B Lock 5, Peter J Houghton 6, Malcolm A Smith 7, David Hall 8, Donald A Barkauskas 8, Mark Krailo 9, Stephan D Voss 10, Stacey L Berg 11, Susan M Blaney 11, Brenda J Weigel 10 Abstract Purpose: Aurora A kinase (AAK) plays an integral role in the mitotic entry, DNA damage checkpoint recovery, and centrosome and spindle maturation. Alisertib (MLN8237) is a […]
June 1, 2019
JorgeDe La Chapaa, Matthew Valdezb, Franscisco RuizIIIb, Keith Gonzalesb, Wes Mitchellb, Stanton F.McHardybc, Matthew Hartbc, Srikanth R.Polusanib, Cara B.Gonzalesac Abstract We previously demonstrated that capsazepine (CPZ), a synthetic transient receptor potential Vanilloid subtype 1 (TRPV1) antagonist, has significant anti-cancer effects in vivo. The purpose of this study was to develop more potent analogs based upon CPZ pharmacophore and structure-activity relationships (SAR) across analogs. We […]
May 17, 2019
M. Gorelik Y. Lee M. Abe T. Andrews L. Davis J. Patterson S. Chen T. R. Crother G. J. Aune M. Noval Rivas M. Arditi Summary Kawasaki disease (KD) vasculitis is an acute febrile illness of childhood characterized by systemic vasculitis of unknown origin and is the most common cause of acquired heart disease among children in the United States. While histological […]
May 15, 2019
Merit L Goodman 1 2 3, Gloria M Trinca 1 2 3, Katherine R Walter 1 2 3, Evangelia K Papachristou 4, Clive S D’Santos 4, Tianbao Li 5, Qi Liu 5, Zhao Lai 5 6, Prabhakar Chalise 7, Rashna Madan 8, Fang Fan 8, Mary A Markiewicz 9, Victor X Jin 5, Jason S Carroll 4, Christy R Hagan 10 2 3 Abstract Why some tumors remain indolent and others progress to clinical relevance remains a major unanswered question in cancer biology. IFN signaling in nascent tumors, mediated by STAT1, is a […]
May 2, 2019
Author links open overlay panelSuhasVasaikar1214ChenHuang1214XiaojingWang121214Vladislav A.Petyuk314Sara R.Savage414BoWen12YongchaoDou12YunZhang1ZhiaoShi12Osama A.Arshad3Marina A.Gritsenko3Lisa J.Zimmerman5Jason E.McDermott3Therese R.Clauss3Ronald J.Moore3RuiZhao3Matthew E.Monroe3Yi-TingWang3Matthew C.Chambers5Robbert J.C.Slebos5Ken S.Lau6QianxingMo713LiDing8MatthewEllis17MathangiThiagarajan9Christopher R.Kinsinger10HenryRodriguez10Richard D.Smith3Karin D.Rodland31115Daniel C.Liebler515TaoLiu315BingZhang1271516 We performed the first proteogenomic study on a prospectively collected colon cancer cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal adjacent tissues produced a catalog of colon cancer-associated proteins and phosphosites, […]
May 1, 2019
Siyuan Zheng, Kristin Alfaro-Munoz, Wei Wei, Xiaojing Wang, Fang Wang, Agda Karina Eterovic, Kenna R Mills Shaw, Funda Meric-Bernstam, Gregory N Fuller, Ken Chen, Roel G Verhaak, Gordon B Mills, WK Alfred Yung, Shiao-Pei Weathers, John F de Groot Malignant gliomas are a group of intracranial cancers associated with disproportionately high mortality and morbidity. Here, […]
May 1, 2019
Siyuan Zheng 1 2 3, Kristin Alfaro-Munoz 4, Wei Wei 5, Xiaojing Wang 3, Fang Wang 6, Agda Karina Eterovic 7, Kenna R Mills Shaw 7, Funda Meric-Bernstam 7, Gregory N Fuller 8, Ken Chen 6, Roel G Verhaak 4 2 6 9, Gordon B Mills 7, W K Alfred Yung 4, Shiao-Pei Weathers 4, John F de Groot 1 Abstract Malignant gliomas are a group of intracranial cancers associated with disproportionately high mortality and morbidity. Here, we report ultradeep targeted sequencing of a prospective cohort of 237 […]