Research Paper
Cell Report: Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma
July 10, 2018
Seçkin Akgül 1, Yinghua Li 2, Siyuan Zheng 3, Marcel Kool 4, Daniel M Treisman 5, Chaoyang Li 2, Yuan Wang 2, Susanne Gröbner 4, Tsuneo Ikenoue 6, Yiping Shen 7, Sandra Camelo-Piragua 8, Gerald Tomasek 9, Sebastian Stark 4, Vinay Guduguntla 9, James F Gusella 7, Kun-Liang Guan 6, Stefan M Pfister 10, Roel G W Verhaak 11, Yuan Zhu 12 Abstract Most human cancers arise from stem and progenitor cells by the sequential accumulation of genetic and epigenetic alterations, while cancer modeling typically requires simultaneous multiple oncogenic events. Here, we […]
Oncotarget: LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer
July 3, 2018
Liqin Du1, Zhenze Zhao1, Milind Suraokar2, Spencer S. Shelton1, Xiuye Ma3, Tzu-Hung Hsiao4, John D. Minna5, Ignacio Wistuba2,6 and Alexander Pertsemlidis3,7 ABSTRACT LMO1 encodes a protein containing a cysteine-rich LIM domain involved in protein-protein interactions. Recent studies have shown that LMO1 functions as an oncogene in several cancer types, including non-small cell lung cancer (NSCLC). However, […]
Cancer Letters: Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells
July 1, 2018
AlfeuZanotto-Filhoac SubapriyaRajamanickama EvaLoranca V. Pragathi Masamsettia AparnaGorthiab July CarolinaRomeroab SonalTonapiab Rosangela Mayer Gonçalvesc Robert L.Reddickd RaymondBenavidese JohnKuhnde YidongChenf Alexander J.R.Bishopab Abstract Molecularly targeted compounds are emerging as a strategy to improve classical chemotherapy. Herein, we describe that using a low dose of the multikinase inhibitor sorafenib improves cyclophosphamide antitumor activity by inhibiting angiogenesis, metastasis, and promoting tumor healing in MDA-MB231 xenografts and the 4T1-12B syngeneic breast […]
The Journal of Physical Chemistry Letters: Extensive Sampling of the Cavity of the GroEL Nanomachine by Protein Substrates Probed by Paramagnetic Relaxation Enhancement
June 21, 2018
Marielle A Wälti 1, David S Libich 1, G Marius Clore 1 Abstract The chaperonin GroEL is an 800 kDa nanomachine comprising two heptameric rings, each of which encloses a large cavity or folding chamber. The GroEL cycle involves ATP-dependent capping of the cavity by the cochaperone GroES to create a nanocage in which a single protein molecule can fold. […]
Cancer Research: Differential Effects of Estrogen Receptor β Isoforms on Glioblastoma Progression
June 15, 2018
Jinyou Liu # 1 2, Gangadhara R Sareddy # 1 3, Mei Zhou 1 4, Suryavathi Viswanadhapalli 1, Xiaonan Li 1, Zhao Lai 5, Rajeshwar R Tekmal 1 3, Andrew Brenner 3 6, Ratna K Vadlamudi 7 3 Abstract The estrogen receptor β (ERβ) functions as a tumor suppressor in glioblastoma (GBM) cells. However, the in vivo significance of endogenous ERβ and the roles of its isoforms in GBM are incompletely understood. Using ERβ isoform-specific PCR screening, we found that GBM cells […]
International Journal of Genomics: Noncoding RNAs and Base Modifications: Epigenomic Players Implicated in Neurological Disorders and Tumorigenesis
June 13, 2018
Zhen Wei,1,2 Subbarayalu Panneerdoss,3,4 Santosh Timilsina,3,4 Jingting Zhu,1,5 Tabrez A. Mohammad,3 Zhi-Liang Lu,1,5 João Pedro de Magalhães,2 Yidong Chen,3,6 Rong Rong,1,5 Yufei Huang,6,7 Manjeet K. Rao,3,4 and Jia Meng1,5 Abstract Background. Compared with the well-studied 5-methylcytosine (m5C) in DNA, the role and topology of epitranscriptome m5C remain insufficiently characterized. Results. By analyzing transcriptome-wide m5C distribution in humans and mice, we show that the m5C modification is significantly enriched […]
Nature Genetics: Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
April 23, 2018
Ana C deCarvalho 1, Hoon Kim 2, Laila M Poisson 3, Mary E Winn 4, Claudius Mueller 5, David Cherba 4, Julie Koeman 6, Sahil Seth 7, Alexei Protopopov 7, Michelle Felicella 8, Siyuan Zheng 9, Asha Multani 10, Yongying Jiang 7, Jianhua Zhang 7, Do-Hyun Nam 11 12 13, Emanuel F Petricoin 5, Lynda Chin 7 9, Tom Mikkelsen 14 15, Roel G W Verhaak 16 Abstract To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft […]
KSAT: “Record grant helps survivor now working at cancer institute that saved him” (video)
April 6, 2018
“Greehey Children’s Cancer Research Institute gets $10.9 million grant” Aune Lab Houghton Lab
International Journal of Mass Spectrometry: Comprehensive and sensitive proteogenomics data analysis strategy based on complementary multi-stage database search
April 1, 2018
Inamul Hasan Madar, Wonyeop Lee, Xiaojing Wang, Seung-Ik Ko, Hokeun Kim, Dong-Gi Mun, Bing Zhang, Eunok Paek, Sang-Won Lee Proteogenomics provides opportunities for proteomic validation of gene structures, genomic alterations, and functional relevance of novel findings obtained from genomic data analysis. However, for effective proteogenomic data integration, an extensive proteome profiling, approaching the gene coverage […]