Journal of Virology: Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants

April 17, 2019

Mingkui Zhou, Michael Humbert, Muhammad M. Mukhtar, Hanna B. Scinto, Hemant K. Vyas, Samir K. Lakhashe, Siddappa N. Byrareddy, Gregor Maurer, Swati Thorat, Joshua Owuor, Zhao Lai, Yidong Chen, Anthony Griffiths, Agnès-Laurence Chenine, Sanjeev Gumber, François Villinger, David Montefiori, Ruth M. Ruprecht ABSTRACT Simian-human immunodeficiency virus (SHIV) infection in rhesus macaques (RMs) resembles human immunodeficiency virus type 1 (HIV-1) infection in humans and serves as a tool to evaluate candidate AIDS vaccines. […]

Pediatric Blood & Cancer: Characterization of pediatric hepatocellular carcinoma reveals genomic heterogeneity and diverse signaling pathway activation

April 11, 2019

Katherine Haines 1, Stephen F Sarabia 2 3, Karla R Alvarez 2 3, Gail Tomlinson 4, Sanjeev A Vasudevan 3 5, Andras A Heczey 3 6, Angshumoy Roy 2 3, Milton J Finegold 2, D Williams Parsons 1 3 6, Sharon E Plon 1 3 6, Dolores López-Terrada 2 3 Abstract Background: Pediatric hepatocellular carcinoma (HCC) is a rare liver tumor in children with a poor prognosis. Comprehensive molecular profiling to understand the underlying genomic drivers of this tumor has not been completed, and it is unclear […]

UT Health SA Newsroom: Greehey cancer researcher receives UT System’s Rising STARs award

April 10, 2019

David Libich, PhD, assistant professor of biochemistry and structural biology in the Long School of Medicine and faculty member of UT Health’s Greehey Children’s Cancer Research Institute, has received a Rising STARs Award from the UT System. The award for early-career investigators comes with a $250,000 grant. Dr. Libich, who began work here in 2017, […]

Nature: Study cancer survivors

April 9, 2019

More and more people are living for years after treatment. Researchers should look for ways to identify and ease long-term effects. When Gregory Aune was 16, he wasn’t particularly concerned about the lasting effects of the drugs and radiation that he was given to treat his lymphoma. “I saw kids around me die, so I […]

The Journal of Clinical Endocrinology & Metabolism: Synonymous but Not Silent: A Synonymous VHL Variant in Exon 2 Confers Susceptibility to Familial Pheochromocytoma and von Hippel-Lindau Disease

April 9, 2019

Shahida K Flores, Ziming Cheng, Angela M Jasper, Keiko Natori, Takahiro Okamoto, Akiyo Tanabe, Koro Gotoh, Hirotaka Shibata, Akihiro Sakurai, Takuya Nakai, Xiaojing Wang, Magnus Zethoven, Shiva Balachander, Yuichi Aita, William Young, Jr., Siyuan Zheng, Kazuhiro Takekoshi, Eijiro Nakamura, Richard W Tothill, Ricardo C T Aguiar, Patricia L M Dahia Abstract Context von Hippel-Lindau (VHL) disease, comprising renal cancer, hemangioblastoma, and/or pheochromocytoma (PHEO), is caused by missense or truncating variants of the VHL tumor-suppressor gene, which […]

Journal of Trauma and Acute Care Surgery: A prospective study in severely injured patients reveals an altered gut microbiome is associated with transfusion volume

April 1, 2019

Susannah E Nicholson 1, David M Burmeister, Taylor R Johnson, Yi Zou, Zhao Lai, Shannon Scroggins, Mark DeRosa, Rachelle B Jonas, Daniel R Merrill, Caroline Zhu, Larry M Newton, Ronald M Stewart, Martin G Schwacha, Donald H Jenkins, Brian J Eastridge Abstract Background: Traumatic injury can lead to a compromised intestinal epithelial barrier and inflammation. While alterations in the gut microbiome of critically injured patients may influence clinical outcomes, the impact […]

Investigative & Clinical Urology: Microbiome diversity in carriers of fluoroquinolone resistant Escherichia coli

March 1, 2019

Michael A Liss 1 2, Robin J Leach 1 3, Elizabeth Rourke 1, Allison Sherrill 1, Teresa Johnson-Pais 1 3, Zhao Lai 4, Joseph Basler 1, James R White 5, Jan E Patterson 6 Abstract Purpose: Fluoroquinolone-resistant (FQR) Escherichia coli causes transrectal prostate biopsy infections. In order to reduce the colonization of these bacteria in carriers, we would like to understand the surrounding microbiome to determine targets for decolonization. Materials and methods: We perform an observational study to […]

Genome Research: PepQuery enables fast, accurate, and convenient proteomic validation of novel genomic alterations

March 1, 2019

Bo Wen, Xiaojing Wang, Bing Zhang Massively parallel or second-generation sequencing-based genomic studies continuously identify new genomic alterations that may lead to novel protein sequences, which are attractive candidates for disease biomarkers and therapeutic targets after proteomic validation. Integrative proteogenomic methods have been developed to use mass spectrometry (MS)-based proteomics data for such validation. These […]