Research Paper
Journal of Pediatric Hematology/Oncology: Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity
April 1, 2018
Wang, Fei PhD*; Iskra, Brian BS†; Kleinerman, Eugenie MD*; Alvarez-Florez, Claudia PhD*; Andrews, Thomas MSc†; Shaw, Angela MD*; Chandra, Joya PhD*; Schadler, Keri PhD*; Aune, Gregory J. MD, PhD†,‡ Abstract We report the cardioprotective effects of moderate aerobic exercise from parallel pediatric murine models of doxorubicin (Doxo) exposure in non–tumor-bearing immune-competent (NTB-IC) mice and tumor-bearing nude mice (TB-NM). […]
Technology Networks: Link Discovered Between BRCA1 Protein and Aggressive Pediatric Cancer
March 8, 2018
Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]
UT Health SA Newsroom: Greehey Institute team finds link between BRCA1 and Ewing sarcoma
March 7, 2018
A mutant oncogene in Ewing traps BRCA1 and prevents it from repairing genetic damage. Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism […]
EurekAlert: Greehey Institute team finds link between BRCA1 and Ewing sarcoma
March 7, 2018
Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]
Life Extension Advocacy Foundation: Greehey Institute team finds link between BRCA1 and Ewing sarcoma
March 7, 2018
Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]
Nature: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
March 7, 2018
Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A. Lawrence, Elicia Goodale, Amanda Balboni Iniguez, Xavier Bernard, V. Pragathi Masamsetti, Sydney Roston, Elizabeth R. Lawlor, Jeffrey A. Toretsky, Kimberly Stegmaier, Stephen L. Lessnick, Yidong Chen & Alexander J. R. Bishop Abstract Ewing sarcoma is an aggressive pediatric cancer of the bone and soft tissue. It results from a chromosomal translocation, predominantly t(11;22)(q24:q12), that fuses the N-terminal transactivation domain of […]
Scientific Reports: Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity
March 6, 2018
Bruna RS Correa, Joanna Hu, Luiz OF Penalva, Richard Schlegel, David L Rimm, Pedro AF Galante, Seema Agarwal Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug target identification and drug discovery efforts. For any model to be clinically relevant, it needs […]
Molecular & Cellular Proteomics: Detection of proteome diversity resulted from alternative splicing is limited by trypsin cleavage specificity
March 1, 2018
Xiaojing Wang, Simona G Codreanu, Bo Wen, Kai Li, Matthew C Chambers, Daniel C Liebler, Bing Zhang Alternative splicing dramatically increases transcriptome complexity but its contribution to proteome diversity remains controversial. Exon-exon junction spanning peptides provide direct evidence for the translation of specific splice isoforms and are critical for delineating protein isoform complexity. Here we […]
Cell Stem Cell: Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma
March 1, 2018
Madeline N Hayes 1, Karin McCarthy 1, Alexander Jin 1, Mariana L Oliveira 2, Sowmya Iyer 1, Sara P Garcia 1, Sivasish Sindiri 3, Berkley Gryder 3, Zainab Motala 4, G Petur Nielsen 5, Jean-Paul Borg 6, Matt van de Rijn 7, David Malkin 4, Javed Khan 3, Myron S Ignatius 8, David M Langenau 9 Abstract Tumor growth and relapse are driven by tumor propagating cells (TPCs). However, mechanisms regulating TPC fate choices, maintenance, and self-renewal are not fully understood. Here, we show that Van […]
Cell: Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection
February 22, 2018
Author links open overlay panelShen-YingZhang12339, Nathaniel E.Clark436, Catherine A.Freije536, Elodie Pauwels136Allison J.Taggart636, SatoshiOkada737, Hanna Mandel8937, PaulaGarcia1037, Michael J.Ciancanelli137, Anat Biran137, Fabien G.Lafaille137, Miyuki Tsumura7, Aurélie Cobat23, Jingchuan Luo1112, StefanoV olpi13, Bastian Zimmer14Sonoko Sakata7Alexandra, Dinis15…Jean-Laurent Casanova1233435 Summary Viruses that are typically benign sometimes invade the brainstem in otherwise healthy children. We report bi-allelic DBR1 mutations in unrelated patients from different […]