Clinical Cancer Research: Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling

December 1, 2018

Michele Dowless, Caitlin D. Lowery, Terry Shackleford, Matthew Renschler, Jennifer Stephens, Robert Flack, Wayne Blosser, Simone Gupta, Julie Stewart, Yue Webster, Jack Dempsey, Alle B. VanWye, Philip Ebert, Philip Iversen, Jonathan B. Olsen, Xueqian Gong, Sean Buchanan, Peter Houghton, and Louis Stancato Abstract Purpose: Ewing sarcoma (ES) is a rare and highly malignant cancer that occurs in the bone and surrounding tissue of children and adolescents. The EWS/ETS fusion transcription factor that drives ES pathobiology was previously demonstrated to modulate cyclin D1 expression. In this study, we evaluated abemaciclib, a small-molecule CDK4, and CDK6 (CDK4 […]

Genome Biology: The proBAM and proBed standard formats: enabling a seamless integration of genomics and proteomics data

December 1, 2018

Gerben Menschaert, Xiaojing Wang, Andrew R Jones, Fawaz Ghali, David Fenyö, Volodimir Olexiouk, Bing Zhang, Eric W Deutsch, Tobias Ternent, Juan Antonio Vizcaíno On behalf of The Human Proteome Organization (HUPO) Proteomics Standards Initiative, we introduce here two novel standard data formats, proBAM and proBed, that have been developed to address the current challenges of […]

International Journal of Cancer: Profiles of brain metastases: Prioritization of therapeutic targets

December 1, 2018

Sherise D Ferguson 1, Siyuan Zheng 2, Joanne Xiu 3, Shouhao Zhou 4, Mustafa Khasraw 5, Priscilla K Brastianos 6, Santosh Kesari 7, Jethro Hu 8, Jeremy Rudnick 8, Michael E Salacz 9, David Piccioni 10, Suyun Huang 1, Michael A Davies 11, Isabella C Glitza 11, John V Heymach 12, Jianjun Zhang 12, Nuhad K Ibrahim 13, John F DeGroot 14, Joseph McCarty 1, Barbara J O’Brien 14, Raymond Sawaya 1, Roeland G W Verhaak 2, Sandeep K Reddy 3, Waldemar Priebe 15, Zoran Gatalica 3, David Spetzler 3, Amy B Heimberger 1 Abstract We sought to compare the tumor profiles of brain metastases from common cancers […]

RNA Biology: Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells

November 18, 2018

Caihong Yi,Guiming Li,Dmitri N. Ivanov,Zhonghua Wang,Mitzli X. Velasco,Greco Hernández,Soni Kaundal,Johanna Villarreal,Yogesh K. Gupta  ,Mei Qiao,Christopher G. Hubert,Matthew J. Hart &Luiz O.F. Penalva ABSTRACT RNA binding proteins have emerged as critical oncogenic factors and potential targets in cancer therapy. In this study, we evaluated Musashi1 (Msi1) targeting as a strategy to treat glioblastoma (GBM); the most […]

Cancer Research: Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis

November 15, 2018

Chadia L Robertson 1, Rachel G Mendoza 1, Nidhi Jariwala 1, Mikhail Dozmorov 2 3, Nitai D Mukhopadhyay 2 3, Mark A Subler 1, Jolene J Windle 1 3, Zhao Lai 4, Paul B Fisher 1 3 5, Shobha Ghosh 6, Devanand Sarkar 7 3 5 Abstract Chronic inflammation is a known hallmark of cancer and is central to the onset and progression of hepatocellular carcinoma (HCC). Hepatic macrophages play a critical role in the inflammatory process leading to HCC. The oncogene Astrocyte […]

Science Daily: Tiny molecule has big effect in childhood brain tumor studies

November 7, 2018

Sometimes small things make the biggest difference. A new study by UT Health San Antonio researchers found that a molecule thousands of times smaller than a gene are able to kill medulloblastoma, the most common childhood brain cancer. This tiny molecule, named MiR-584-5p, is quite efficient in its action. MiR-584-5p sensitizes cancer to chemotherapy and […]

European Urology: Metabolic Biosynthesis Pathways Identified from Fecal Microbiome Associated with Prostate Cancer

November 1, 2018

Michael A Liss 1, James Robert White 2, Martin Goros 3, Jonathan Gelfond 3, Robin Leach 4, Teresa Johnson-Pais 4, Zhao Lai 5, Elizabeth Rourke 4, Joseph Basler 4, Donna Ankerst 4, Dimpy P Shah 3 Abstract Background: The fecal microbiome is associated with prostate cancer risk factors (obesity, inflammation) and can metabolize and produce various products that may influence cancer but have yet to be defined in prostate cancer. Objective: To investigate gut bacterial diversity, identify specific […]

Nature Communications: MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

October 31, 2018

Nourhan Abdelfattah, Subapriya Rajamanickam, Subbarayalu Panneerdoss, Santosh Timilsina, Pooja Yadav, Benjamin C. Onyeagucha, Michael Garcia, Ratna Vadlamudi, Yidong Chen, Andrew Brenner, Peter Houghton & Manjeet K. Rao Abstract Despite improvements in overall survival, only a modest percentage of patients survive high-risk medulloblastoma. The devastating side effects of radiation and chemotherapy substantially reduce the quality of life for surviving patients. Here, using genomic screens, we identified miR-584-5p as a […]

International Journal of Oncology: Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma

October 5, 2018

Jorge De La Chapa, Prajjal Kanti Singha, Mckay Sallaway, Kristen Self, Ranna  Nasreldin, Ramesh Dasari, Matthew Hart., Alexander Kornienko, Jeremy  Just, Jason A. Smith, Alex C. Bissember, Cara B. Gonzales Abstract Polygodial, a drimane sesquiterpenoid dialdehyde isolated as a pungent component of the water pepper Persicaria hydropiper, exhibits antifeedant, antimicrobial, anti-inflammatory, and anticancer effects. Polygodial also activates transient receptor potential vanilloid subtype 1 (TRPV1) […]