RNA Biology: Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells

November 18, 2018

Caihong Yi,Guiming Li,Dmitri N. Ivanov,Zhonghua Wang,Mitzli X. Velasco,Greco Hernández,Soni Kaundal,Johanna Villarreal,Yogesh K. Gupta  ,Mei Qiao,Christopher G. Hubert,Matthew J. Hart &Luiz O.F. Penalva ABSTRACT RNA binding proteins have emerged as critical oncogenic factors and potential targets in cancer therapy. In this study, we evaluated Musashi1 (Msi1) targeting as a strategy to treat glioblastoma (GBM); the most […]

Cancer Research: Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis

November 15, 2018

Chadia L Robertson 1, Rachel G Mendoza 1, Nidhi Jariwala 1, Mikhail Dozmorov 2 3, Nitai D Mukhopadhyay 2 3, Mark A Subler 1, Jolene J Windle 1 3, Zhao Lai 4, Paul B Fisher 1 3 5, Shobha Ghosh 6, Devanand Sarkar 7 3 5 Abstract Chronic inflammation is a known hallmark of cancer and is central to the onset and progression of hepatocellular carcinoma (HCC). Hepatic macrophages play a critical role in the inflammatory process leading to HCC. The oncogene Astrocyte […]

EurekAlert: Tiny molecule has big effect in childhood brain tumor studies

November 7, 2018

Sometimes small things make the biggest difference. A new study by UT Health San Antonio researchers found that a molecule thousands of times smaller than a gene is able to kill medulloblastoma, the most common childhood brain cancer. This tiny molecule, named MiR-584-5p, is quite efficient in its action. MiR-584-5p sensitizes the cancer to chemotherapy […]

Science Daily: Tiny molecule has big effect in childhood brain tumor studies

November 7, 2018

Sometimes small things make the biggest difference. A new study by UT Health San Antonio researchers found that a molecule thousands of times smaller than a gene are able to kill medulloblastoma, the most common childhood brain cancer. This tiny molecule, named MiR-584-5p, is quite efficient in its action. MiR-584-5p sensitizes cancer to chemotherapy and […]

European Urology: Metabolic Biosynthesis Pathways Identified from Fecal Microbiome Associated with Prostate Cancer

November 1, 2018

Michael A Liss 1, James Robert White 2, Martin Goros 3, Jonathan Gelfond 3, Robin Leach 4, Teresa Johnson-Pais 4, Zhao Lai 5, Elizabeth Rourke 4, Joseph Basler 4, Donna Ankerst 4, Dimpy P Shah 3 Abstract Background: The fecal microbiome is associated with prostate cancer risk factors (obesity, inflammation) and can metabolize and produce various products that may influence cancer but have yet to be defined in prostate cancer. Objective: To investigate gut bacterial diversity, identify specific […]

Nature Communications: MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

October 31, 2018

Nourhan Abdelfattah, Subapriya Rajamanickam, Subbarayalu Panneerdoss, Santosh Timilsina, Pooja Yadav, Benjamin C. Onyeagucha, Michael Garcia, Ratna Vadlamudi, Yidong Chen, Andrew Brenner, Peter Houghton & Manjeet K. Rao Abstract Despite improvements in overall survival, only a modest percentage of patients survive high-risk medulloblastoma. The devastating side effects of radiation and chemotherapy substantially reduce the quality of life for surviving patients. Here, using genomic screens, we identified miR-584-5p as a […]

International Journal of Oncology: Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma

October 5, 2018

Jorge De La Chapa, Prajjal Kanti Singha, Mckay Sallaway, Kristen Self, Ranna  Nasreldin, Ramesh Dasari, Matthew Hart., Alexander Kornienko, Jeremy  Just, Jason A. Smith, Alex C. Bissember, Cara B. Gonzales Abstract Polygodial, a drimane sesquiterpenoid dialdehyde isolated as a pungent component of the water pepper Persicaria hydropiper, exhibits antifeedant, antimicrobial, anti-inflammatory, and anticancer effects. Polygodial also activates transient receptor potential vanilloid subtype 1 (TRPV1) […]

Science Advances: Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression

October 3, 2018

Subbarayalu Panneerdoss1,2,*, Vijay K. Eedunuri1,2,*, Pooja Yadav1,2, Santosh Timilsina1,2, Subapriya Rajamanickam2,3, Suryavathi Viswanadhapalli4, View ORCID ProfileNourhan Abdelfattah1,2, Benjamin C. Onyeagucha1,2, View ORCID ProfileXiadong Cui5, Zhao Lai2, View ORCID ProfileTabrez A. Mohammad2, View ORCID ProfileYogesh K. Gupta2,6, Tim Hui-Ming uang3, Yufei Huang5,†, View ORCID ProfileYidong Chen2,7,† and View ORCID ProfileManjeet K. Rao1,2,† Abstract The importance of RNA methylation in biological processes is an emerging focus of the investigation. We report that altering […]

American Journal of Surgery: Polytrauma independent of therapeutic intervention alters the gastrointestinal microbiome

October 1, 2018

Susannah E Nicholson 1, Daniel Merrill 2, Caroline Zhu 3, David M Burmeister 4, Yi Zou 5, Zhao Lai 6, Daniel N Darlington 7, Aaron M Lewis 8, Larry Newton 9, Shannon Scroggins 10, Brian J Eastridge 11, Martin G Schwacha 12 Abstract Background: This study characterizes the gastrointestinal (GI) microbiome in a pre-clinical polytrauma hemorrhage model. Methods: Rats (n = 6) were anesthetized, hemorrhaged 20% of their blood volume, and subjected to a femur fracture and crush injuries to […]