Methods: A protocol for RNA methylation differential analysis with MeRIP-Seq data and exomePeak R/Bioconductor package

October 1, 2014

Author links open overlay panelJiaMenga,  ZhiliangLua,  HuiLiub,  LinZhangb,  ShaowuZhangc, YidongChende, Manjeet K.Raoef,  YufeiHuanggd Abstract Despite the prevalent studies of DNA/Chromatin-related epigenetics, such as, histone modifications and DNA methylation, RNA epigenetics has not drawn deserved attention until a new affinity-based sequencing approach MeRIP-Seq was developed and applied to survey the global mRNA N6-methyladenosine (m6A) in mammalian cells. As a marriage of […]

Congressional Childhood Cancer Caucus: Caucus Applauds NCI for Naming Pediatric Oncologist to Council of Research Advocates

September 30, 2014

National Cancer Institute Names UTHSCSA Pediatric Hematologist-Oncologist to Council of Research Advocates The National Cancer Institute (NCI) recently nominated a new member to its NCI Council of Research Advocates, Greg Aune, a pediatric hematologist-oncologist from The University of Texas Health Science Center at San Santonio. The announcement was made last Friday by NCI director Harold Varmus in a closed-door briefing on pediatric cancer for childhood cancer […]

San Antonio Report: Greehey Institute Receives $3.7 Million Cancer Grant

September 26, 2014

A cancer diagnosis is difficult news for anyone, and it can be particularly frightening and heart-wrenching for a family with a cancer-stricken child living in a lower-income area without access to adequate health care. The National Cancer Institute has awarded a $3.7 million grant to the Greehey Children’s Cancer Research Institute at the UT Health Science Center to address […]

TPR: $3.7 Million Grant Will Help UTHSCSA Study Children’s Cancer

September 24, 2014

Children’s cancer research in San Antonio is getting a boost from the National Cancer Institute. A new infusion of $3.7 million is dedicated to helping an underserved population in South Texas. South Central Texas is designated is one of 12 sites in the United States with the largest populations of underserved minority children.

New England Journal of Medicine: AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

September 11, 2014

Emmanuel S. Antonarakis, MD, Changxue Lu, PhD, Hao Wang, PhD, Brandon Luber, Sc.M., Mary Nakazawa, M.H.S., Jeffrey C. Roeser, B.S., Yan Chen, PhD, Tabrez A. Mohammad, PhD, Yidong Chen, PhD, Helen L. Fedor, B.S., Tamara L. Lotan, MD, Qizhi Zheng, MD, Angelo M. De Marzo, MD, PhD, John T. Isaacs, PhD, William B. Isaacs, PhD, Rosa Nadal, MD, Channing J. Paller, MD, Samuel R. Denmeade, MD, Michael A. Carducci, MD, Mario A. Eisenberger, MD, and […]

Mechanisms of Ageing and Development: Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction

September 1, 2014

Wilson C.Foka CarolinaLivibc AlexBokovcd ZhenYue YidongChendfg ArlanRichardsonah Viviana I.Pérezhi Abstract Rapamycin, a drug that has been shown to increase lifespan in mice, inhibits the target of rapamycin (TOR) pathway, a major pathway that regulates cell growth and energy status. It has been hypothesized that rapamycin and dietary restriction (DR) extends lifespan through similar mechanisms/pathways. Using […]

PLoS One: Genome-Wide Association Analysis of Radiation Resistance in Drosophila melanogaster

August 14, 2014

Mahesh Vaisnav, Chao Xing, Hung-Chih Ku, Daniel Hwang, Strahinja Stojadinovic, Alexander Pertsemlidis, John M. Abrams  Abstract Background Ionizing radiation is genotoxic to cells. Healthy tissue toxicity in patients and radiation resistance in tumors present common clinical challenges in delivering effective radiation therapies. Radiation response is a complex, polygenic trait with unknown genetic determinants. The Drosophila Genetic Reference […]

St. Baldrick’s: UT Health Science Center Pediatric Cancer Researcher Receives Grant in Groundbreaking Work for Childhood Cancer Survivors

August 13, 2014

UT Health Science Center Pediatric Cancer Researcher Receives Grant in Groundbreaking Work for Childhood Cancer Survivors A pediatric hematologist-oncologist from the University of Texas Health Science Center at San Antonio has been awarded a grant from the St. Baldrick’s Foundation to continue his groundbreaking work into the long-term problems that lifesaving chemotherapy can cause in […]

Oncogene: Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer

July 31, 2014

S Mishra 1, J J Deng 1, P S Gowda 1, M K Rao 1, C-L Lin 2, C L Chen 2, T Huang 3, L-Z Sun 4 Abstract Prostate cancer cells escape growth inhibition from transforming growth factor β (TGFβ) by downregulating TGFβ receptors. However, the mechanism by which cancer cells downregulate TGFβ receptors in the prostate is not clear. Here, we showed that coordinated action of miR-21 and […]

Hepatology: Astrocyte elevated gene‐1 and c‐Myc cooperate to promote hepatocarcinogenesis in mice

July 28, 2014

Jyoti Srivastava Ayesha Siddiq Rachel Gredler Xue‐Ning Shen Devaraja Rajasekaran  Chadia L. Robertson  Mark A. Subler  Jolene J. Windle  Catherine I. Dumur  Nitai D. Mukhopadhyay  Dawn Garcia  Zhao Lai  Yidong Chen  Uthra Balaji  Paul B. Fisher  Devanand Sarkar Abstract Astrocyte elevated gene‐1 (AEG‐1) and c‐Myc are overexpressed in human hepatocellular carcinoma (HCC) functioning as oncogenes. AEG‐1 is transcriptionally regulated by c‐Myc, and AEG‐1 itself induces c‐Myc by activating the […]