Research Paper
Oncogene:miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer
September 16, 2013
L Du, Z Zhao, X Ma, T-H Hsiao, Y Chen, E Young, M Suraokar, I Wistuba, J D Minna & A Pertsemlidis Abstract The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully […]
Modern Pathology: Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium
September 6, 2013
Dolores López-Terrada 1, Rita Alaggio 2, Maria T de Dávila 3, Piotr Czauderna 4, Eiso Hiyama 5, Howard Katzenstein 6, Ivo Leuschner 7, Marcio Malogolowkin 8, Rebecka Meyers 9, Sarangarajan Ranganathan 10, Yukichi Tanaka 11, Gail Tomlinson 12, Monique Fabrè 13, Arthur Zimmermann 14, Milton J Finegold 1, Children’s Oncology Group Liver Tumor Committee Abstract Liver tumors are rare in children, and their diagnoses may be challenging particularly because of the lack of a current consensus classification system. Systematic central histopathological review of these tumors […]
Oncogene: Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer
August 26, 2013
S S Roy 1, V K Gonugunta 1, A Bandyopadhyay 2, M K Rao 3, G J Goodall 4, L-Z Sun 3, R R Tekmal 5, R K Vadlamudi 5 Abstract Tumor metastasis is the leading cause of death among breast cancer patients. PELP1 (proline, glutamic acid, and leucine-rich protein 1) is a nuclear receptor coregulator that is upregulated during breast cancer progression to metastasis and is an independent prognostic […]
Cancer Cell: Amplification of Distant Estrogen Response Elements Deregulates Target Genes Associated with Tamoxifen Resistance in Breast Cancer
August 12, 2013
Pei-YinHsu1 Hang-KaiHsu1 XunLan6 LiranJuan9 Pearlly S.Yan7 JadwigaLabanowska8 NylaHeerema8 Tzu-HungHsiao4 Yu-ChiaoChiu5 YidongChen34 YunlongLiu9 LangLi9RongLi1I an M.Thompson2 Kenneth P.Nephew10 Zelton D.Sharp 1 Nameer B.Kirma1 Victor X.Jin6 Tim H.-M.Huang1 Summary A causal role of gene amplification in tumorigenesis is well known, whereas amplification of DNA regulatory elements as an oncogenic driver remains unclear. In this study, we integrated next-generation sequencing approaches to map distant estrogen response elements (DEREs) that […]
Experimental Hematology: Myelodysplastic syndrome: An inability to appropriately respond to damaged DNA?
August 1, 2013
Author links open overlay panelTingZhouab PaulHastycde Christi A.Walterbdef Alexander J.R.Bishopabde Linda M.Scottg Vivienne I.Rebelabde Myelodysplastic syndrome (MDS) is considered a hematopoietic stem cell disease that is characterized by abnormal hematopoietic differentiation and a high propensity to develop acute myeloid leukemia. It is mostly associated with advanced age, but also with prior cancer therapy and inherited […]
Pediatric Blood & Cancer: Outcomes for patients with congenital hepatoblastoma
June 24, 2013
Angela D Trobaugh-Lotrario 1, Barbara H Chaiyachati, Rebecka L Meyers, Beate Häberle, Gail E Tomlinson, Howard M Katzenstein, Marcio H Malogolowkin, Dietrich von Schweinitz, Mark Krailo, James H Feusner Abstract Background: Congenital hepatoblastoma, diagnosed in the first month of life, has been reported to have a poor prognosis; however, a comprehensive evaluation of this entity is lacking. Procedure: We retrospectively reviewed two patients from the senior authors’ […]
Bioinformatics: Exome-based analysis for RNA epigenome sequencing data
June 15, 2013
Jia Meng, Xiaodong Cui, Manjeet K. Rao, Yidong Chen, Yufei Huang Abstract Motivation: Fragmented RNA immunoprecipitation combined with RNA sequencing enabled the unbiased study of RNA epigenome at a near single-base resolution; however, unique features of this new type of data call for novel computational techniques. Result: Through examining the connections of RNA epigenome sequencing data with two well-studied data […]
Echocardiography: Cardiac Assessment in Pediatric Mice: Strain Analysis as a Diagnostic Measurement
June 7, 2013
Thomas G. Andrews, M.Sc.,* Merry L. Lindsey, PhD,† Richard A. Lange, MD, M.B.A,‡ and Gregory J. Aune, MD, PhD§ Echocardiography is a robust tool for assessing cardiac function in both humans and laboratory animals. Conventional echocardiographic measurements, including chamber dimensions, wall thickness, and ejection fraction are routinely obtained to assess cardiac function in mice. Recently, […]
IEEE: Estimating Conditional Probabilities for the Detection of Unfavorable Copy Number Alterations in a Targeted Therapy
June 5, 2013
Fang-Han Hsu; Edward R. Dougherty; Yidong Chen; Erchin Serpedin Abstract: Emerging targeted therapies have shown benefits such as less toxicity and higher effectiveness in specific types of cancer treatment; however, the accessibility of these advantages may rely on the correct identification of suitable patients, which remains highly immature. We assume that copy number profiles, being accessible genomic data […]
Diabetes Journal: Enhanced NF-κB Activity Impairs Vascular Function Through PARP-1–, SP-1–, and COX-2–Dependent Mechanisms in Type 2 Diabetes
June 1, 2013
Modar Kassan1,2, Soo-Kyoung Choi1, Maria Galán1,2, Alexander Bishop3, Kazuo Umezawa4, Mohamed Trebak5, Souad Belmadani2⇑ , and Khalid Matrougui1,2⇑ Abstract Type 2 diabetes (T2D) is associated with vascular dysfunction. We hypothesized that increased nuclear factor-κB (NF-κB) signaling contributes to vascular dysfunction in T2D. We treated type 2 diabetic (db−/db−) and control (db−/db+) mice with two NF-κB inhibitors (6 mg/kg dehydroxymethylepoxyquinomicin twice a week […]