Category
September 26, 2014
A cancer diagnosis is difficult news for anyone, and it can be particularly frightening and heart-wrenching for a family with a cancer-stricken child living in a lower-income area without access to adequate health care. The National Cancer Institute has awarded a $3.7 million grant to the Greehey Children’s Cancer Research Institute at the UT Health Science Center to address […]
September 24, 2014
Children’s cancer research in San Antonio is getting a boost from the National Cancer Institute. A new infusion of $3.7 million is dedicated to helping an underserved population in South Texas. South Central Texas is designated is one of 12 sites in the United States with the largest populations of underserved minority children.
September 11, 2014
Emmanuel S. Antonarakis, MD, Changxue Lu, PhD, Hao Wang, PhD, Brandon Luber, Sc.M., Mary Nakazawa, M.H.S., Jeffrey C. Roeser, B.S., Yan Chen, PhD, Tabrez A. Mohammad, PhD, Yidong Chen, PhD, Helen L. Fedor, B.S., Tamara L. Lotan, MD, Qizhi Zheng, MD, Angelo M. De Marzo, MD, PhD, John T. Isaacs, PhD, William B. Isaacs, PhD, Rosa Nadal, MD, Channing J. Paller, MD, Samuel R. Denmeade, MD, Michael A. Carducci, MD, Mario A. Eisenberger, MD, and […]
September 1, 2014
Wilson C.Foka CarolinaLivibc AlexBokovcd ZhenYue YidongChendfg ArlanRichardsonah Viviana I.Pérezhi Abstract Rapamycin, a drug that has been shown to increase lifespan in mice, inhibits the target of rapamycin (TOR) pathway, a major pathway that regulates cell growth and energy status. It has been hypothesized that rapamycin and dietary restriction (DR) extends lifespan through similar mechanisms/pathways. Using […]
August 14, 2014
Mahesh Vaisnav, Chao Xing, Hung-Chih Ku, Daniel Hwang, Strahinja Stojadinovic, Alexander Pertsemlidis, John M. Abrams Abstract Background Ionizing radiation is genotoxic to cells. Healthy tissue toxicity in patients and radiation resistance in tumors present common clinical challenges in delivering effective radiation therapies. Radiation response is a complex, polygenic trait with unknown genetic determinants. The Drosophila Genetic Reference […]
August 13, 2014
UT Health Science Center Pediatric Cancer Researcher Receives Grant in Groundbreaking Work for Childhood Cancer Survivors A pediatric hematologist-oncologist from the University of Texas Health Science Center at San Antonio has been awarded a grant from the St. Baldrick’s Foundation to continue his groundbreaking work into the long-term problems that lifesaving chemotherapy can cause in […]
July 31, 2014
S Mishra 1, J J Deng 1, P S Gowda 1, M K Rao 1, C-L Lin 2, C L Chen 2, T Huang 3, L-Z Sun 4 Abstract Prostate cancer cells escape growth inhibition from transforming growth factor β (TGFβ) by downregulating TGFβ receptors. However, the mechanism by which cancer cells downregulate TGFβ receptors in the prostate is not clear. Here, we showed that coordinated action of miR-21 and […]
July 28, 2014
Jyoti Srivastava Ayesha Siddiq Rachel Gredler Xue‐Ning Shen Devaraja Rajasekaran Chadia L. Robertson Mark A. Subler Jolene J. Windle Catherine I. Dumur Nitai D. Mukhopadhyay Dawn Garcia Zhao Lai Yidong Chen Uthra Balaji Paul B. Fisher Devanand Sarkar Abstract Astrocyte elevated gene‐1 (AEG‐1) and c‐Myc are overexpressed in human hepatocellular carcinoma (HCC) functioning as oncogenes. AEG‐1 is transcriptionally regulated by c‐Myc, and AEG‐1 itself induces c‐Myc by activating the […]
July 15, 2014
Lucie M Turcotte 1, Michael K Georgieff, Julie A Ross, James H Feusner, Gail E Tomlinson, Marcio H Malogolowkin, Mark D Krailo, Nicole Miller, Rachel Fonstad, Logan G Spector Abstract Background: Hepatoblastoma is a malignancy of young children. Low birth weight is associated with a significantly increased risk of hepatoblastoma and neonatal medical exposures are hypothesized as contributors. This study represents the largest case-control study of […]
June 17, 2014
Bhuvanesh Dave, Sergio Granados-Principal, Rui Zhu, Stephen Benz, Shahrooz Rabizadeh, Patrick Soon-Shiong, Ke-Da Yu, Zhimin Shao, Xiaoxian Li, Michael Gilcrease, Zhao Lai, Yidong Chen, Tim H.-M. Huang, Haifa Shen, Xuewu Liu, Mauro Ferrari, Ming Zhan, Stephen T. C. Wong, Muthiah Kumaraswami, Vivek Mittal, Xi Chen, Steven S. Gross, and Jenny C. Chang Abstract We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. Selective shRNA knockdown identified ribosomal protein L39 (RPL39) […]