Research Paper
Pediatric Blood & Cancer: Clinical, histologic, and genetic features of mesothelioma in a 7-year-old child
September 7, 2012
Aaron Sugalski 1, Mary Davis, Latha Prasannan, Victor Saldivar, Jaclyn Y Hung, Gail E Tomlinson Abstract Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was […]
Journal of Clinical Investigation: ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression
August 1, 2012
Young-Ho Ahn,1 Don L. Gibbons,1,2 Deepavali Chakravarti,3 Chad J. Creighton,4 Zain H. Rizvi,1 Henry P. Adams,5 Alexander Pertsemlidis,6 Philip A. Gregory,7,8 Josephine A. Wright,7,8 Gregory J. Goodall,7,8,9 Elsa R. Flores,3 and Jonathan M. Kurie1 Abstract Metastatic cancer is extremely difficult to treat, and the presence of metastases greatly reduces a cancer patient’s likelihood of long-term survival. The ZEB1 transcriptional repressor promotes metastasis through downregulation of microRNAs (miRs) […]
Cancer Epidemiology Biomarkers & Prevention: A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers
August 1, 2012
Yuan C Ding 1, Lesley McGuffog, Sue Healey, Eitan Friedman, Yael Laitman, Shani- Paluch-Shimon, Bella Kaufman, SWE-BRCA; Annelie Liljegren, Annika Lindblom, Håkan Olsson, Ulf Kristoffersson, Marie Stenmark-Askmalm, Beatrice Melin, Susan M Domchek, Katherine L Nathanson, Timothy R Rebbeck, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna Durda, Jacek Gronwald, Tomasz Huzarski, Cezary Cybulski, Tomasz Byrski, Ana Osorio, Teresa Ramóny Cajal, Alexandra V Stavropoulou, Javier Benítez, Ute Hamann, HEBON; Matti Rookus, Cora M Aalfs, Judith L de Lange, Hanne E J Meijers-Heijboer, Jan C Oosterwijk, Christi J van Asperen, Encarna B Gómez García, Nicoline Hoogerbrugge, Agnes Jager, Rob […]
DNA Repair Protocols: Identification of Genes Required for Damage Survival Using a Cell-Based RNAi Screen Against the Drosophila Genome
July 23, 2012
Abstract Exposure to DNA-damaging agents invokes biological responses necessary for damage recovery and cell survival. Despite the presence of intact DNA repair pathways, a lack of certain other biological pathways has been shown to sensitize cells to DNA-damaging agents’ exposure. It is likely that following DNA damage a complex interplay between DNA repair pathways and […]
PLOS One: Androgen-Responsive MicroRNAs in Mouse Sertoli Cells
July 20, 2012
Subbarayalu Panneerdoss, Yao-Fu Chang, Kalyan C. Buddavarapu, Hung-I Harry Chen, Gunapala Shetty, Huizhen Wang, Yidong Chen, T. Rajendra Kumar, Manjeet K. Rao Abstract Although decades of research have established that androgen is essential for spermatogenesis, androgen’s mechanism of action remains elusive. This is in part because only a few androgen-responsive genes have been definitively identified in the testis. Here, we propose that […]
Pediatric Blood & Cancer: Genetics and epigenetics of hepatoblastoma
July 13, 2012
Gail E Tomlinson 1, Roland Kappler Abstract A number of unique genetic features are observed in hepatoblastoma that has provided insights into the origins of hepatoblastoma. Hallmark cytogenetic changes in hepatoblastoma include the acquisition of additional copies of whole chromosomes and a recurring unbalanced translocation involving 1q. Genetic syndromes are associated with approximately 15% of hepatoblastoma and […]
IEEE: Evaluating Dynamic Effects of Copy Number Alterations on Gene Expression Using a Single Transcription Model
July 13, 2012
Fang-Han Hsu; Erchin Serpedin; Yidong Chen; Edward R. Dougherty Abstract: DNA copy number alterations (CNAs) are known to be related to genetic diseases, including cancer. The unlimited transcription (UT) model, in which transcription occurs permissively with a simple activation probability, has been proposed to investigate the long-term effects of CNAs on gene expression values. The queueing theory was […]
Expert Opinion on Biological Therapy: microRNA regulation of cell viability and drug sensitivity in lung cancer
June 26, 2012
Liqin Du , & Alexander Pertsemlidis Abstract Introduction:microRNAs (miRNAs) are 19 – 23 nucleotide long RNAs found in multiple organisms that regulate gene expression and have been shown to play important roles in tumorigenesis. In the context of lung cancer, numerous studies have shown that tumor suppressor genes and oncogenes that play crucial roles in […]
Transnational Cancer Research: Chain-reaction, a model of gene expression dynamics
June 21, 2012
Submitted May 21, 2012. Accepted for publication Jun 21, 2012. doi: 10.3978/j.issn.2218-676X.2012.06.01 One of the fundamental studies of transcription response to stimuli is to model the activation, repression of hundreds of genes, and their regulations. To further complicate the scenario, genes are regulated by multiple transcription factors, operating through different modes (earlier activation or secondary […]
PLoS One: miR-337-3p and Its Targets STAT3 and RAP1A Modulate Taxane Sensitivity in Non-Small Cell Lung Cancers
June 18, 2012
Liqin Du, Maria C. Subauste, Christopher DeSevo, Zhenze Zhao, Michael Baker, Robert Borkowski, Jeoffrey J. Schageman, Rachel Greer, Chin-Rang Yang, Milind Suraokar, Ignacio I. Wistuba, Adi F. Gazdar, John D. Minna, Alexander Pertsemlidis Abstract NSCLC (non-small cell lung cancer) often exhibits resistance to paclitaxel treatment. Identifying the elements regulating paclitaxel response will advance efforts to […]