EURASIP Journal on Bioinformatics and Systems Biology: Identification of genomic functional hotspots with copy number alteration in liver cancer

October 25, 2013

Tzu-Hung Hsiao, Hung-I Harry Chen, Stephanie Roessler, Xin Wei Wang & Yidong Chen Abstract Copy number alterations (CNAs) can be observed in most cancer patients. Several oncogenes and tumor suppressor genes with CNAs have been identified in different kinds of tumors. However, the systematic survey of CNA-affected functions is still lack. By employing systems biology approaches, instead of examining individual […]

Cancer Epidemiology Biomarkers & Preventinon: Parental tobacco and alcohol use and risk of hepatoblastoma in offspring: a report from the children’s oncology group

October 15, 2013

Kimberly J Johnson 1, Katherine S Williams, Julie A Ross, Mark D Krailo, Gail E Tomlinson, Marcio H Malogolowkin, James H Feusner, Logan G Spector Abstract Background: Hepatoblastoma is a rare pediatric liver tumor that has significantly increased in incidence over the last several decades. The International Agency for Research on Cancer (IARC) recently classified hepatoblastoma as tobacco-related cancer. Parental alcohol use has shown […]

Taylor Francis: A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel

September 30, 2013

Liqin Du, Robert Borkowski, Zhenze Zhao, Xiuye Ma, Xiaojie Yu, Xian-Jin Xie &Alexander Pertsemlidis microRNAs (miRNAs) are small RNAs endogenously expressed in multiple organisms that regulate gene expression largely by decreasing levels of target messenger RNAs (mRNAs). Over the past few years, numerous studies have demonstrated critical roles for miRNAs in the pathogenesis of many cancers, […]

Frontiers in Psychiatry: The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers

September 23, 2013

Jason D Robinson 1, Francesco Versace, Cho Y Lam, Jennifer A Minnix, Jeffrey M Engelmann, Yong Cui, Maher Karam-Hage, Sanjay S Shete, Gail E Tomlinson, Tina T-L Chen, David W Wetter, Charles E Green, Paul M Cinciripini Abstract A compromised brain reward system has been postulated as a key feature of drug dependence. We examined whether several polymorphisms of genes found to regulate nicotinic acetylcholine receptor (nAChR) and […]

Echocardiography: Cardiac Assessment in Pediatric Mice: Strain Analysis as a Diagnostic Measurement

September 19, 2013

Thomas G. Andrews M.Sc. Merry L. Lindsey PhD Richard A. Lange MD, M.B.A Gregory J. Aune MD, PhD Abstract Echocardiography is a robust tool for assessing cardiac function in both humans and laboratory animals. Conventional echocardiographic measurements, including chamber dimensions, wall thickness, and ejection fraction are routinely obtained to assess cardiac function in mice. Recently, [...]

Oncogene:miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer

September 16, 2013

L Du, Z Zhao, X Ma, T-H Hsiao, Y Chen, E Young, M Suraokar, I Wistuba, J D Minna & A Pertsemlidis Abstract The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully […]

Modern Pathology: Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium

September 6, 2013

Dolores López-Terrada 1, Rita Alaggio 2, Maria T de Dávila 3, Piotr Czauderna 4, Eiso Hiyama 5, Howard Katzenstein 6, Ivo Leuschner 7, Marcio Malogolowkin 8, Rebecka Meyers 9, Sarangarajan Ranganathan 10, Yukichi Tanaka 11, Gail Tomlinson 12, Monique Fabrè 13, Arthur Zimmermann 14, Milton J Finegold 1, Children’s Oncology Group Liver Tumor Committee Abstract Liver tumors are rare in children, and their diagnoses may be challenging particularly because of the lack of a current consensus classification system. Systematic central histopathological review of these tumors […]

Oncogene: Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer

August 26, 2013

S S Roy 1, V K Gonugunta 1, A Bandyopadhyay 2, M K Rao 3, G J Goodall 4, L-Z Sun 3, R R Tekmal 5, R K Vadlamudi 5 Abstract Tumor metastasis is the leading cause of death among breast cancer patients. PELP1 (proline, glutamic acid, and leucine-rich protein 1) is a nuclear receptor coregulator that is upregulated during breast cancer progression to metastasis and is an independent prognostic […]

Cancer Cell: Amplification of Distant Estrogen Response Elements Deregulates Target Genes Associated with Tamoxifen Resistance in Breast Cancer

August 12, 2013

Pei-YinHsu1  Hang-KaiHsu1  XunLan6  LiranJuan9  Pearlly S.Yan7  JadwigaLabanowska8  NylaHeerema8  Tzu-HungHsiao4  Yu-ChiaoChiu5  YidongChen34  YunlongLiu9  LangLi9RongLi1I  an M.Thompson2  Kenneth P.Nephew10  Zelton D.Sharp  1 Nameer B.Kirma1  Victor X.Jin6  Tim H.-M.Huang1 Summary A causal role of gene amplification in tumorigenesis is well known, whereas amplification of DNA regulatory elements as an oncogenic driver remains unclear. In this study, we integrated next-generation sequencing approaches to map distant estrogen response elements (DEREs) that […]

Experimental Hematology: Myelodysplastic syndrome: An inability to appropriately respond to damaged DNA?

August 1, 2013

Author links open overlay panelTingZhouab PaulHastycde Christi A.Walterbdef Alexander J.R.Bishopabde Linda M.Scottg Vivienne I.Rebelabde Myelodysplastic syndrome (MDS) is considered a hematopoietic stem cell disease that is characterized by abnormal hematopoietic differentiation and a high propensity to develop acute myeloid leukemia. It is mostly associated with advanced age, but also with prior cancer therapy and inherited […]