Research Paper
Experimental Hematology: Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm
April 1, 2012
Author links open overlay panelStephanie N.Zimmerab∗ Madeleine E.Lemieuxc∗ Bijal P.Kariaab ClaudiaDayb TingZhouab QingZhoub Andrew L.Kungc UthraSuresh bYidongChenbd Marsha C.Kinneye Alexander J.R.Bishopab Vivienne I.Rebel Myelodysplastic syndrome is a complex family of preleukemic diseases in which hematopoietic stem cell defects lead to abnormal differentiation in one or more blood lineages. Disease progression is associated with increased genomic […]
Journal of Clinical Oncology: Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers
March 19, 2012
Brian S Finkelman 1, Wendy S Rubinstein, Sue Friedman, Tara M Friebel, Shera Dubitsky, Niecee Singer Schonberger, Rochelle Shoretz, Christian F Singer, Joanne L Blum, Nadine Tung, Olufunmilayo I Olopade, Jeffrey N Weitzel, Henry T Lynch, Carrie Snyder, Judy E Garber, Joellen Schildkraut, Mary B Daly, Claudine Isaacs, Gabrielle Pichert, Susan L Neuhausen, Fergus J Couch, Laura van’t Veer, Rosalind Eeles, Elizabeth Bancroft, D Gareth Evans, Patricia A Ganz, Gail E Tomlinson, Steven A Narod, Ellen Matloff, Susan Domchek, Timothy R Rebbeck Abstract Purpose: Mutations in BRCA1/2 […]
Molecular Biology of the Cell: Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells
February 22, 2012
Shu Lin 1, Junhua Yang, Abdel G Elkahloun, Abhik Bandyopadhyay, Long Wang, John E Cornell, I-Tien Yeh, Joseph Agyin, Gail Tomlinson, Lu-Zhe Sun Abstract The molecular mechanisms that drive triple-negative, basal-like breast cancer progression are elusive. Few molecular targets have been identified for the prevention or treatment of this disease. Here we developed a series of isogenic basal-like human mammary epithelial cells (HMECs) with altered […]
Gastroenterology: Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival
December 3, 2011
Background & Aims Hepatocellular carcinoma (HCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. We used an integrative approach to identify HCC driver genes, defined as genes whose copy numbers associate with gene expression and cancer progression.
Stand Genomic Sciences: Minimum Information about a Genotyping Experiment (MIGEN)
November 30, 2011
Jie Huang, Daniel Mirel, Elizabeth Pugh, Chao Xing, Peter N Robinson, Alexander Pertsemlidis, Lianghao Ding, Julia Kozlitina, Joseph Maher, Jonathan Rios, Michael Story, Nishanth Marthandan, Richard H Scheuermann Abstract Genotyping experiments are widely used in clinical and basic research laboratories to identify associations between genetic variations and normal/abnormal phenotypes. Genotyping assay techniques vary from single genomic regions that are interrogated using PCR reactions to high throughput assays […]
Breast Cancer Research: Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
November 12, 2011
Anna Marie Mulligan 1, Fergus J Couch, Daniel Barrowdale, Susan M Domchek, Diana Eccles, Heli Nevanlinna, Susan J Ramus, Mark Robson, Mark Sherman, Amanda B Spurdle, Barbara Wappenschmidt, Andrew Lee, Lesley McGuffog, Sue Healey, Olga M Sinilnikova, Ramunas Janavicius, Thomas vO Hansen, Finn C Nielsen, Bent Ejlertsen, Ana Osorio, Iván Muñoz-Repeto, Mercedes Durán, Javier Godino, Maroulio Pertesi, Javier Benítez, Paolo Peterlongo, Siranoush Manoukian, Bernard Peissel, Daniela Zaffaroni, Elisa Cattaneo, Bernardo Bonanni, Alessandra Viel, Barbara Pasini, Laura Papi, Laura Ottini, Antonella Savarese, Loris Bernard, Paolo Radice, Ute Hamann, Martijn Verheus, Hanne E J Meijers-Heijboer, Juul Wijnen, Encarna B Gómez […]
Biotechniques: Isolation of Sertoli, Leydig, and spermatogenic cells from the mouse testis
November 5, 2011
Yao-Fu Chang 1, Jennifer S Lee-Chang, Subbarayalu Panneerdoss, James A MacLean 2nd, Manjeet K Rao Abstract A thorough understanding of the events during mammalian spermatogenesis requires studying specific molecular signatures of individual testicular cell populations as well as their interaction in co-cultures. However, most purification techniques to isolate specific testicular cell populations are time-consuming, require large numbers of animals, and/or […]
Journal of Biological Chemistry: Mutant p53 Disrupts Role of ShcA Protein in Balancing Smad Protein-dependent and -independent Signaling Activity of Transforming Growth Factor-β (TGF-β)*
October 26, 2011
Shu Lin‡, Lan Yu‡, Junhua Yang‡, Zhao Liu‡, Bijal Karia‡§, Alexander J. R. Bishop‡§¶, James Jackson‖, Guillermina Lozano‖, John A. Copland**, Xiaoxin Mu‡‡‡, Beicheng Sun‡‡ and Lu-Zhe Sun‡¶,1 Abstract Biomarkers are lacking for identifying the switch of transforming growth factor-β (TGF-β) from tumor-suppressing to tumor-promoting. Mutated p53 (mp53) has been suggested to switch TGF-β to a tumor promoter. However, we found that mp53 does not always promote […]
IEEE: Stochastic Modeling of the Relationship between Copy Number and Gene Expression Based on Transcriptional Logic
October 24, 2011
Fang-Han Hsu; Erchin Serpedin; Yidong Chen; Edward R. Dougherty Abstract: DNA copy number alterations (CNAs) can cause genetic diseases, and studies have revealed a relationship between CNAs and gene expression; however, the manner in which CNAs relate to gene expression and what regulatory mechanisms underlying the relationship remain unclear. In many instances, real data have revealed a nonlinear […]
Molecular Profiling: Genome-Wide Methylation Profiling in Archival Formalin-Fixed Paraffin-Embedded Tissue Samples
October 21, 2011
J. Keith Killian, Robert L. Walker, Sven Bilke, Yidong Chen, Sean Davis, Robert Cornelison, William I. Smith, Paul S. Meltzer Abstract New technologies allow for the genome-scale measurement of DNA methylation. In an effort to increase the clinical utility of DNA methylation as a biomarker, we have adapted a commercial bisulfite epigenotype assay for genome-wide methylation profiling in archival formalin-fixed paraffin-embedded pathology specimens. This […]