Cancer Prevention Research: Pubertal Bisphenol A Exposure Alters Murine Mammary Stem Cell Function Leading to Early Neoplasia in Regenerated Glands
April 1, 2014
Danhan Wang, Hui Gao, Abhik Bandyopadhyay, Anqi Wu, I-Tien Yeh, Yidong Chen, Yi Zou, Changjiang Huang, Christi A. Walter, Qiaoxiang Dong, and Lu-Zhe Sun Abstract Perinatal exposure to bisphenol A (BPA) has been shown to cause aberrant mammary gland morphogenesis and mammary neoplastic transformation. Yet, the underlying mechanism is poorly understood. We tested the hypothesis that mammary glands exposed to BPA during a susceptible window may lead to its susceptibility to tumorigenesis through a stem cell-mediated mechanism. […]