Research Paper

Cancer Epidemiology Biomarkers & Prevention: Polymorphisms in CYP1A1 and ethnic-specific susceptibility to acute lymphoblastic leukemia in children.

July 1, 2011

Ryan M Swinney 1, Joke Beuten, Anderson B Collier 3rd, Tina T-L Chen, Naomi J Winick, Brad H Pollock, Gail E Tomlinson Abstract Background: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The U.S. Surveillance Epidemiology and End Results (SEER) registry reports that Hispanic children have the highest incidence of ALL, however, it is unclear if this is due to genetic […]

Pediatric Developmental Pathology: Activated NOTCH2 is overexpressed in hepatoblastomas: an immunohistochemical study

June 3, 2011

Jason B Litten 1, Tina T-L Chen, Roger Schultz, Karl Herman, Jessica Comstock, Joshua Schiffman, Gail E Tomlinson, Dinesh Rakheja Abstract Hepatoblastoma is a pediatric malignancy characterized by the uncontrolled proliferation of immature hepatocytes (hepatoblasts). This disease is diagnosed primarily in children younger than 5 years and is disproportionately observed in former premature infants. Cytogenetically, hepatoblastoma is characterized by numerical aberrations, as well […]

Cancer Epidemiology Biomarkers & Prevention: Multilocus association of genetic variants in MLL, CREBBP, EP300, and TOP2A with childhood acute lymphoblastic leukemia in Hispanics from Texas

June 1, 2011

Duangjai Piwkham 1, Jonathan A L Gelfond, Budsaba Rerkamnuaychoke, Samart Pakakasama, Vivienne I Rebel, Brad H Pollock, Naomi J Winick, Anderson B Collier 3rd, Gail E Tomlinson, Joke Beuten Abstract Background: Hispanic children have both a higher incidence and a poorer outcome in acute lymphoblastic leukemia (ALL). Moreover, a higher incidence for therapy-related acute myeloid leukemia with 11q23 translocations after treatment with topoisomerase II (topo II) […]

Plos One: Preferential Localization of Human Origins of DNA Replication at the 5′-Ends of Expressed Genes and at Evolutionarily Conserved DNA Sequences

May 13, 2011

Manuel S. Valenzuela  ,Yidong Chen ,Sean Davis,Fan Yang,Robert L. Walker,Sven Bilke,John Lueders,Melvenia M. Martin,Mirit I. Aladjem,Pierre P. Massion, Paul S. Meltzer  Abstract Background Replication of mammalian genomes requires the activation of thousands of origins which are both spatially and temporally regulated by as yet unknown mechanisms. At the most fundamental level, our knowledge about the distribution pattern […]

JoVE Journal: Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium

February 27, 2011

Alison Claybon1, Alexander J. R. Bishop1 Abstract The retinal pigment epithelium (RPE) lies at the back of the mammalian eye, just under the neural retina, which contains the photoreceptors (rods and cones). The RPE is a monolayer of pigmented cuboidal cells and associates closely with the neural retina just above it. This association makes the RPE […]

Cancer Cell: Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma

February 1, 2011

Brian P.Rubin1, KoichiNishijo2, Hung-I HarryChen2, XiaolanYi2, David P.Schuetze1, RanadipPal3, Suresh I.Prajapati2, JinuAbraham2, Benjamin R.Arenkiel4, Qing-RongChen5, SeanDavis6, Amanda T.McCleish2, Mario R.Capecchi7, Joel E.Michalek8, Lee AnnZarzabal8, JavedKhan5, ZhongxinYu9, David M.Parham9, CharlesKeller2111213 Summary Embryonal rhabdomyosarcoma (eRMS) shows the most myodifferentiation among sarcomas, yet the precise cell of origin remains undefined. Using Ptch1, p53, and/or Rb1 conditional mouse models and controlling prenatal or postnatal myogenic cell […]

Journal of Molecular Cancer Biology: Cancer and neurodegenerative disorders: pathogenic convergence through microRNA regulation

January 28, 2011

Liqin Du, Alexander Pertsemlidis Abstract Although cancer and neurodegenerative disease are two distinct pathological disorders, emerging evidence indicates that these two types of disease share common mechanisms of genetic and molecular abnormalities. Recent studies show that individual microRNAs (miRNAs) could be involved in the pathology of both diseases, indicating that the mechanisms of these two seemingly […]

PLOS One: 14-3-3 σ Expression Effects G2/M Response to Oxygen and Correlates with Ovarian Cancer Metastasis

January 10, 2011

Dashnamoorthy Ravi, Yidong Chen, Bijal Karia, Adam Brown, Ting Ting Gu, Jie Li, Mark S. Carey, Bryan T. Hennessy, Abstract Background In vitro cell, culture experiments with primary cells have reported that cell proliferation is retarded in the presence of ambient compared to physiological O2 levels. Cancer is primarily a disease of aberrant cell proliferation, therefore, studying cancer cells grown under ambient O2 may […]

Biological Psychology: The serotonin transporter gene and startle response during nicotine deprivation

January 1, 2011

Jennifer A Minnix 1, Jason D Robinson, Cho Y Lam, Brian L Carter, Jennifer E Foreman, David J Vandenbergh, Gail E Tomlinson, David W Wetter, Paul M Cinciripini Abstract Affective startle probe methodology was used to examine the effects of nicotine administration and deprivation on emotional processes among individuals carrying at least one s allele versus those with the l/l genotype of the 5-Hydroxytryptamine […]

Cancer Genetics: Identification of genetic susceptibility to childhood cancer through analysis of genes in parallel

January 1, 2011

Sharon E Plon 1, David A Wheeler, Louise C Strong, Gail E Tomlinson, Michael Pirics, Qingchang Meng, Hannah C Cheung, Phyllis R Begin, Donna M Muzny, Lora Lewis, Jaclyn A Biegel, Richard A Gibbs Erratum in Cancer Genet. 2011 May;204(5):284 Abstract Clinical cancer genetic susceptibility analysis typically proceeds sequentially, beginning with the most likely causative gene. The process is time-consuming and the yield is low, particularly for […]